Carbohydrate Research, Год журнала: 2023, Номер 530, С. 108874 - 108874
Опубликована: Июнь 16, 2023
Язык: Английский
In Silico Pharmacology, Год журнала: 2025, Номер 13(1)
Опубликована: Фев. 10, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3136 - 3136
Опубликована: Март 28, 2025
In a hidden corner of the Earth, an ongoing war is being waged: battle between lichens and microorganisms. Lichens, ancient unique symbiotic organisms, with their survival wisdom, are bursting vitality in extreme environments. Over 80% secondary metabolites not found other making lichen-derived compounds promising resource for development new drugs, particularly against drug-resistant microorganisms, due to distinctive chemical structures biological activities. This article aims explore depth lichen species exhibiting antimicrobial activity focus on such as divaricatic acid, usnic vulpinic salazinic rhizocarpic which demonstrate significant effects various resistant including methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Candida albicans Meanwhile, this paper discusses potential applications challenges associated use medicine, agriculture, food industry, aiming elucidate these mysterious organisms researchers enthusiasts while promoting further research field antimicrobials.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(5), С. 548 - 548
Опубликована: Апрель 23, 2025
Background/Objectives: Parietin (PTN), a blue-light absorbing pigment from Teloschistes spp. lichens, exhibit photosensitizing properties via Type I (superoxide anion, O2•−) and II (singlet oxygen, 1O2) mechanisms, inactivating bacteria in vitro after photoexcitation. We evaluate the antifungal activity of PTN against Candida tropicalis biofilms under actinic irradiation, its role O2•− 1O2 production, cellular stress response. Methods: Minimum inhibitory concentration (MIC) was determined C. NCPF 3111 dark light conditions. Biofilm susceptibility assessed at MIC/2, MIC, MICx2, MICx4, MICx6 same conditions, viability measured by colony-forming units. Photodynamic mechanisms were examined using Tiron (O2•− scavenger) or sodium azide (1O2 quencher). production nitro-blue tetrazolium (NBT) reduction nitric oxide (NO) generation Griess assay. Total antioxidant capacity studied FRAP (Ferrous Reduction Antioxidant Potency) assay superoxide dismutase (SOD) NBT Results: Photoexcitation reduced biofilm four logs MICx2. Sodium partially reversed effect, whereas fully inhibited it, indicating critical O2•−. also increased NO levels, enhancing SOD FRAP. However, this response insufficient to prevent photoinactivation. Conclusions: Photoinactivation is primarily mediated O2•−, with minor contribution an imbalance levels. These findings suggest promising photosensitizer for photodynamic therapy.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 1200 - 1200
Опубликована: Янв. 18, 2024
Caffeic acid (CA) is one of the most abundant natural compounds present in plants and has a broad spectrum beneficial pharmacological activities. However, some cases, synthetic derivation original molecules can expand their scope. This study focuses on synthesis caffeic phosphanium derivatives with ambition increasing biological Four salts (CAPs) were synthesized tested for cytotoxic, antibacterial, antifungal, amoebicidal activity vitro, aim identifying best area medicinal use. CAPs exhibited significantly stronger cytotoxic against cell lines (HeLa, HCT116, MDA-MB-231 MCF-7, A2058, PANC-1, Jurkat) comparison to acid. Focusing Jurkat cells (human leukemic T lymphoma), IC50 value ranged from 0.9 8.5 μM while CA was >300 μM. Antimicrobial testing also confirmed higher selected microbes CA, especially Gram-positive bacteria (MIC 13-57 μM) yeast Candida albicans μM). The anti-Acanthamoeba studied two pathogenic Acanthamoeba strains. In case A. lugdunensis, all revealed inhibitory effect (EC50 74-3125 than (>105 µM), quina strain, inhibition observed three 44-291 newly quaternary selective antitumor action appeared be promising antimicrobial agents topical application, as well potential further research.
Язык: Английский
Процитировано
2
Fungal Biology Reviews, Год журнала: 2024, Номер 51, С. 100410 - 100410
Опубликована: Дек. 24, 2024
Язык: Английский
Процитировано
2
Tetrahedron Letters, Год журнала: 2024, Номер 141, С. 155069 - 155069
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
1
Carbohydrate Research, Год журнала: 2024, Номер 541, С. 109158 - 109158
Опубликована: Май 22, 2024
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6782 - 6782
Опубликована: Июнь 20, 2024
Gyrophoric acid (GA), a lichen secondary metabolite, has attracted more attention during the last years because of its potential biological effects. Until now, effect in vivo not yet been demonstrated. The aim our study was to evaluate basic physicochemical and pharmacokinetic properties GA, which are directly associated with activities. stability GA various pH assessed by conducting repeated UV-VIS spectral measurements. Microsomal rat liver microsomes performed using Ultra-Performance LC/MS. Binding human serum albumin (HSA) synchronous fluorescence spectra, molecular docking analysis used reveal binding site HSA. In experiment, 24 Sprague-Dawley rats (Velaz, Únetice, Czech Republic) were used. animals divided as follows. first group (
Язык: Английский
Процитировано
1
Green Chemistry, Год журнала: 2024, Номер 26(19), С. 10205 - 10224
Опубликована: Янв. 1, 2024
The recent growing interest in the biological properties of lichen metabolites has evidenced different needs and challenges for further exploration, including development green processing with safer solvents more efficient use energy.
Язык: Английский
Процитировано
1
Tetrahedron, Год журнала: 2024, Номер unknown, С. 134432 - 134432
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1