Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

The EPMA Journal, Год журнала: 2024, Номер 15(2), С. 163 - 205

Опубликована: Апрель 18, 2024

Despite their subordination in humans, to a great extent, mitochondria maintain independent status but tightly cooperate with the "host" on protecting joint life quality and minimizing health risks. Under oxidative stress conditions, healthy promptly increase mitophagy level remove damaged "fellows" rejuvenating mitochondrial population sending fragments of mtDNA as SOS signals all systems human body. As long metabolic pathways are under systemic control well-concerted together, adaptive mechanisms become triggered increasing protection, activating antioxidant defense repair machinery. Contextually, attributes patho-/physiology instrumental for predictive medical approach cost-effective treatments tailored individualized patient profiles primary (to protect vulnerable individuals again health-to-disease transition) secondary affected disease progression) care. Nutraceuticals naturally occurring bioactive compounds demonstrating health-promoting, illness-preventing, other health-related benefits. Keeping mind health-promoting properties nutraceuticals along therapeutic potential safety profile, there is permanently growing demand application mitochondria-relevant nutraceuticals. Application beneficial only if meeting needs at individual level. Therefore, risk assessment creation pivotal importance followed by adapted nutraceutical sets needs. Based scientific evidence available nutraceuticals, this article presents examples frequent which require protective measures targeted holistic following advanced concepts predictive, preventive, personalized medicine (PPPM/3PM)

Язык: Английский

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Opportunities, Challenges, and Scientific Progress in Hemp Crops

Molecules, Год журнала: 2024, Номер 29(10), С. 2397 - 2397

Опубликована: Май 20, 2024

The resurgence of cannabis (Cannabis sativa L.) has been propelled by changes in the legal framework governing its cultivation and use, increased demand for hemp-derived products, studies recognizing industrial health benefits hemp. This led to creation novel high-cannabidiol, low-Δ9-tetrahydrocannabinol varieties, enabling hemp crop expansion worldwide. review elucidates recent implications Europe, with a focus on legislative impacts practices, prospective breeding efforts, dynamic scientific landscape surrounding this crop. We also current cultivars’ cannabinoid composition European market major differences that United States.

Язык: Английский

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Irvingia gabonensis baill. (African Mango): A comprehensive review of its ethnopharmacological significance, unveiling its long-standing history and therapeutic potential

Journal of Ethnopharmacology, Год журнала: 2024, Номер 326, С. 117942 - 117942

Опубликована: Фев. 21, 2024

Язык: Английский

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Nanotechnology and flavonoids: Current research and future perspectives on cardiovascular health

Journal of Functional Foods, Год журнала: 2024, Номер 120, С. 106355 - 106355

Опубликована: Июль 26, 2024

Язык: Английский

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Cardiovascular protective effects of natural flavonoids on intestinal barrier injury

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Язык: Английский

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Ternary complex of Kaempferol-Hydroxypropyl-β-Cyclodextrin-Liposomes against hepatocellular carcinoma: Preparation, validation, pharmacokinetics and efficacy studies

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125261 - 125261

Опубликована: Янв. 1, 2025

Язык: Английский

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A Comparative Study of the Biological Properties of Eugenia uniflora L. Fruits and Leaves Related to the Prevention of Cardiovascular Diseases

Life, Год журнала: 2025, Номер 15(2), С. 147 - 147

Опубликована: Янв. 22, 2025

Cardiovascular diseases (CVDs) remain the leading cause of death globally, emphasizing need for effective preventive strategies. Plant-based foods, rich in phytochemicals, offer a promising potential CVD prevention. This study investigated antioxidant, anti-inflammatory, and antihypertensive properties two Eugenia uniflora L. varieties (orange purple pitanga) their leaves. Their antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation assays, while evaluated through angiotensin-converting enzyme (ACE) inhibition. anti-inflammatory determined via protein denaturation Both fruit exhibited similar bioactivities, with variety showing slightly higher activity, except DPPH ABTS assays. The leaves consistently demonstrated lowest activities across all Free polyphenols, dominated by gallic acid, were quantified µ-QuEChERS followed ultrahigh-performance liquid chromatography (UHPLC-PDA). orange contained highest concentration acid (13.1 mg/100 g DW). These findings highlight extracts as natural agents, suggesting value food, pharmaceutical, cosmetic applications promoting human health preventing CVDs.

Язык: Английский

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The enhanced excited-state intramolecular proton transfer energy barrier of flavonols induced by deprotonation

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер unknown, С. 126146 - 126146

Опубликована: Март 1, 2025

Язык: Английский

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Kaempferol inhibits cardiomyocyte pyroptosis via promoting O-GlcNAcylation of GSDME and improved acute myocardial infarction

BMC Pharmacology and Toxicology, Год журнала: 2025, Номер 26(1)

Опубликована: Апрель 8, 2025

Язык: Английский

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An electrochemical sensor based on MWCNTs and a PCCN₂₂₂ peroxidase-like nanocomposite for sensitive and selective kaempferol detection

RSC Advances, Год журнала: 2025, Номер 15(15), С. 11319 - 11326

Опубликована: Янв. 1, 2025

An electrochemical sensor based on MWCNTs and PCCN222 peroxidase-like nanocomposite. Sensitive selective kaempferol detection. High stability, strong anti-interference ability, low detection limit.

Язык: Английский

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