Dietary anti-inflammatory and anti-bacterial medicinal plants and its compounds in bovine mastitis associated impact on human life

Microbial Pathogenesis, Год журнала: 2024, Номер 192, С. 106687 - 106687

Опубликована: Май 13, 2024

Язык: Английский

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Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1354 - 1354

Опубликована: Окт. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Язык: Английский

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Strategy for preparing of glucosinolate derivatives with outstanding functional activities based on myrosinase

Food Chemistry, Год журнала: 2025, Номер 479, С. 143778 - 143778

Опубликована: Март 8, 2025

Язык: Английский

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Heteroatom-doped carbon dots from medicinal plants as novel biomaterials for as-use biomedical applications in comparison with synthetic drug, zaltoprofen

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 7, 2024

Abstract FN-doped carbon dots were synthesized using powdered leaves of Moringa oleifera L./ Chromolaena odorata Tridax procumbens Tinospora cordifolia and Lantana camara L., along with a precursor called 4,5-difluoro-1,2-benzenediamine (DFBD) compared against the drug zaltoprofen derived dots. They assessed for their optical structural characteristics photoluminescence (optimal emission λ 600 nm), vibrational (FTIR) spectroscopy (characteristic wave numbers 1156 1269 cm −1 C–F), as well X-ray diffraction (XRD) (highest intensity at 27.56°) high-resolution transmission electron microscopy (HR-TEM) (particles in size range 15–20 nm). Further, field scanning (FESEM) / energy dispersive (EDX) indicated FN doping oval/oblong Membrane protection percent is found to be 55.3 80.4 FN-CDs Z-FN-CDs respectively. The DPPH-free radical scavenging activity by was 69.4%, while Z-FN-CDs, it 54.2%. When tested on six bacterial strains (three each gram-positive gram-negative), displayed halo (ZOI) between 9 19 mm, whereas clearance zone 17 mm. showed significant emission-red-shift effects demonstrated concentration-dependent biocompatibility viability neuroblastoma beta-TC6-cell lines.

Язык: Английский

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Moringa oleifera in a modern time: A comprehensive review of its nutritional and bioactive composition as a natural solution for managing diabetes mellitus by reducing oxidative stress and inflammation

Food Research International, Год журнала: 2025, Номер 201, С. 115671 - 115671

Опубликована: Янв. 5, 2025

Язык: Английский

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Exploring Design Strategies for Healthier Fruit Smoothies

Current Food Science and Technology Reports, Год журнала: 2025, Номер 3(1)

Опубликована: Фев. 5, 2025

Язык: Английский

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Enhancing active ingredient biosynthesis in Chinese herbal medicine: biotechnological strategies and molecular mechanisms

PeerJ, Год журнала: 2025, Номер 13, С. e18914 - e18914

Опубликована: Фев. 10, 2025

Background Chinese herbal medicine (CHM) is a fundamental component of traditional medical practice, offering rich source natural remedies with significant therapeutic potential. However, the scarcity active ingredients and complex extraction procedures present substantial challenges to their widespread clinical application. This review aims address this gap by exploring potential modern biotechnological advancements in enhancing biosynthesis these valuable compounds. Methodology The study takes comprehensive approach, delving into chemical composition CHM’s elucidating biosynthetic pathways molecular regulatory mechanisms. Additionally, it surveys recent progress methodologies evaluates engineering strategies aimed at synthetic production. multifaceted analysis forms foundation for examining role biology augmenting ingredient synthesis. Results Our examination provides insights intricate governing formation ingredients, as well networks that underlie processes. Furthermore, highlights techniques, demonstrating ability streamline enhance isolation Engineering approaches production, including metabolic tools, are assessed overcome limitations scale up Conclusions By integrating from biosynthesis, regulation, methodologies, biology, establishes robust theoretical framework production ingredients. proposed practical guidance aim facilitate broader utilization while promoting sustainability accessibility within invaluable medicinal heritage.

Язык: Английский

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Exploring the Therapeutic Potential of Moringa Oleifera Leaves: Health Benefits and Applications

International Journal of Scientific Research in Science and Technology, Год журнала: 2025, Номер 12(1), С. 637 - 657

Опубликована: Фев. 23, 2025

Moringa oleifera, commonly known as the drumstick tree, has garnered significant attention in recent years due to its impressive array of nutritional and medicinal properties. This research paper provides an in-depth review therapeutic potential M. oleifera leaves, emphasizing their health benefits diverse applications. The bioactive compounds found including vitamins, minerals, antioxidants, phytochemicals, play crucial roles efficacy for treating preventing a wide range conditions. Specifically, leaves exhibit potent antioxidant, anti-inflammatory, antimicrobial, anti-cancer properties, making them valuable combating chronic diseases such diabetes, cardiovascular diseases, certain cancers. Additionally, are effective addressing malnutrition have been extensively used traditional medicine various ailments. also explores integration into modern medical practices, highlighting nutraceuticals, pharmaceuticals, functional foods. Further is warranted fully elucidate mechanisms action harness improving public on global scale.

Язык: Английский

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Unveiling the Miracle Tree: Therapeutic Potential of Moringa oleifera in Chronic Disease Management and Beyond

Biomedicines, Год журнала: 2025, Номер 13(3), С. 634 - 634

Опубликована: Март 5, 2025

Moringa oleifera (MO) has gained recognition as a potent natural intervention for preventing and managing chronic diseases (CDs) due to its diverse phytochemical composition pharmacological properties. Rich in antioxidants, polyphenols, flavonoids, glucosinolates, MO exerts anti-inflammatory, anti-hyperglycemic, cardioprotective, anti-obesity effects. These properties make it valuable therapeutic agent CDs, including diabetes, cardiovascular diseases, obesity, neurodegenerative disorders, cancer. MO’s ability modulate oxidative stress inflammation—key drivers of CDs—highlights significant role disease prevention treatment. enhances insulin sensitivity, regulates lipid profiles blood pressure, reduces inflammation, protects against damage. also modulates key signaling pathways involved cancer liver prevention. Studies suggest that extracts possess anticancer activity by modulating apoptosis, inhibiting tumor cell proliferation, interacting with pathways, YAP/TAZ, Nrf2-Keap1, TLR4/NF-κB, Wnt/β-catenin. However, challenges such variability bioactive compounds, taste acceptability, inconsistent clinical outcomes limit their widespread application. While preclinical studies support efficacy, large-scale trials, standardized formulations, advanced delivery methods are needed optimize potential. multifunctional applications promising sustainable solution combating especially resource-limited settings.

Язык: Английский

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Advancing Alzheimer's Therapy with Moringa oleifera: Bioactive Insights, Mechanistic Pathways, and Strategies for Efficacy and Standardization

The Open Medicinal Chemistry Journal, Год журнала: 2025, Номер 19(1)

Опубликована: Фев. 18, 2025

Alzheimer’s disease (AD) represents a devastating condition that profoundly impacts the quality of life for both affected individuals and their families. Currently, there is no viable treatment AD. Conventional drugs AD provide symptomatic relief by temporarily improving cognitive function or slowing progression specific symptoms. These medications do not stop reverse underlying neurodegeneration, offering only modest benefits in managing disease, often come with unpleasant side effects, making adherence challenging patients. Natural treatments made from plants have drawn interest potential to lessen symptoms while having lesser side-effect profile. Among these, Moringa oleifera ( M. ), also referred as “miracle tree,” has gained attention its wide range health benefits, including antioxidant, anti-inflammatory neuroprotective properties. By delving into bioactive compounds underpinning mechanisms action, exploring through various omics technologies, addressing challenges associated standardization, this review provides an in-depth analysis therapy. This highlights need further research unlock full spectrum factors could enhance efficacy combating bridging phytochemical properties practical therapeutic applications. Therefore, understanding harnessing pave way more effective interventions management.

Язык: Английский

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