Sustainable Valorization of Fruit and Vegetable Waste for Bioactive Compounds: Advancing Functional Food and Wellness
Waste and Biomass Valorization,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 9, 2025
Язык: Английский
Melatonin-governed growth and metabolome divergence: Circadian and stress responses in key plant species
Plant Physiology and Biochemistry,
Год журнала:
2025,
Номер
221, С. 109635 - 109635
Опубликована: Фев. 10, 2025
Melatonin,
a
versatile
biomolecule,
profoundly
influences
plant
growth
and
resilience
through
its
intricate
regulation
of
metabolic
pathways,
circadian
rhythms,
cellular
processes.
The
current
study
elucidates
melatonin's
concentration-dependent
biphasic
effects
on
dynamics
in
Arabidopsis
thaliana
Brassica
nigra.
While
50
μM
melatonin
optimized
biomass
accumulation
root
elongation,
higher
concentrations
(100
μM)
elicited
stress
responses,
underscoring
dual
role
as
promoter
modulator.
Melatonin
extended
photosynthetic
efficiency
by
modulating
chlorophyll
carotenoid
synthesis
diurnally,
offering
protection
against
photodamage.
Divergent
responses
between
the
two
species,
driven
species-specific
reprogramming,
were
evident
pigment
biosynthesis
antioxidant
pathways.
B.
nigra
displayed
robust
activation
flavonoid
phenylpropanoid
cytokinin
signaling,
enhanced
oxidative
defenses,
contrasting
with
A.
thaliana,
where
suppressed
precursors
activation.
Metabolomic
analysis
revealed
orchestration
hormonal
crosstalk,
involving
auxins,
gibberellins,
jasmonates,
to
fine-tune
adaptation.
Stomatal
cell
wall
fortification
highlighted
optimizing
water-use
structural
under
abiotic
stress.
Cytogenetic
studies
confirmed
safeguarding
genomic
integrity,
regulating
chromatin
remodeling,
promoting
DNA
repair
mechanisms,
demonstrating
adaptive
strategies
Moreover,
influenced
critical
including
polyamine
biosynthesis,
sulfur
metabolism,
nucleotide
regulation,
emphasizing
multifaceted
impact
homeostasis.
These
findings
position
cornerstone
molecule
biotechnology,
potential
applications
enhancing
crop
productivity
fluctuating
environmental
conditions.
Язык: Английский
Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 403 - 403
Опубликована: Март 13, 2025
Background:
Carotenoids
are
bioactive
tetraterpenoid
C40
pigments
that
actively
synthesized
by
plants,
bacteria,
and
fungi.
Compounds
such
as
α-carotene,
β-carotene,
lycopene,
lutein,
astaxanthin,
β-cryptoxanthin,
fucoxanthin,
zeaxanthin
have
attracted
increasing
attention
for
their
antiaging
properties.
They
exhibit
antioxidant,
neuroprotective,
anti-inflammatory
properties,
contributing
to
the
prevention
treatment
of
age-related
diseases.
Objectives:
The
aim
this
study
was
comprehensively
analyze
pharmacological
potential
biological
mechanisms
carotenoids
associated
with
disorders
evaluate
application
in
nutraceuticals,
pharmaceuticals,
cosmeceuticals.
Methods:
A
systematic
review
studies
published
over
past
two
decades
conducted
using
databases
PubMed,
Scopus,
Web
Science.
selection
criteria
included
clinical,
silico,
vivo,
vitro
investigating
therapeutic
effects
carotenoids.
Results:
demonstrate
a
variety
health
benefits,
including
macular
degeneration,
cancer,
cognitive
decline,
metabolic
disorders,
skin
aging.
Their
role
nutraceuticals
is
well
supported
ability
modulate
oxidative
stress
inflammatory
pathways.
In
show
promising
results
formulations
targeting
neurodegenerative
diseases
disorders.
cosmeceuticals,
they
improve
protecting
it
against
UV
radiation
damage.
However,
bioavailability,
optimal
dosages,
toxicity,
interactions
other
compounds
remain
critical
factors
maximize
efficacy
still
require
careful
evaluation
scientists.
Conclusions:
interventions
applications
fields.
Further
research
needed
optimize
formulas,
confirm
long-term
safety
effectiveness,
especially
aging
population.
Язык: Английский
Metabolic Syndrome Prevention Potential of Tamarillo: Phytochemical Composition, Antioxidant Activity, and Enzyme Inhibition Before and After Digestion
Foods,
Год журнала:
2025,
Номер
14(7), С. 1282 - 1282
Опубликована: Апрель 7, 2025
Tamarillo
(Solanum
betaceum
Cav.)
is
rich
in
polyphenols,
anthocyanins,
and
carotenoids,
making
it
a
promising
candidate
for
functional
food
development.
This
study
investigated
phytochemical
profiles
bioactivities
different
tamarillo
parts.
Various
parts
of
were
extracted
using
water
ethanol
(0-95%),
with
95%
yielding
the
highest
content
bioactive
compounds
peel,
pulp,
mucilage,
whole
fruit,
while
75%
was
more
effective
seeds.
Among
components,
peel
exhibited
concentrations
hydroxycinnamoyl
derivatives,
along
superior
antioxidant
capacity,
including
strong
scavenging
activity
against
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
radicals
(EC50,
45.26
µg
extract/mL)
high
reducing
power
113.3
extract/mL).
The
extract
strongest
inhibitory
effects
on
α-glucosidase
(IC50,
1.623
mg/mL)
angiotensin-converting
enzymes
1.435
mg/mL).
In
contrast,
pulp
demonstrated
pancreatic
lipase
0.882
α-amylase
2.369
These
findings
suggest
that
extracts
possess
potent
enzyme-inhibitory
properties
related
to
metabolic
syndrome
(MetS).
However,
gastrointestinal
digestion
simulation
influenced
compound
bioactivities.
Overall,
has
potential
as
ingredient
MetS
prevention,
but
processing
strategies
are
needed
retain
its
properties.
Язык: Английский
Clinical management of eye diseases: carotenoids and their nanoformulations as choice of therapeutics
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 21, 2024
Язык: Английский
Protective Effects of Astaxanthin against Oxidative Stress: Attenuation of TNF-α-Induced Oxidative Damage in SW480 Cells and Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in C57BL/6 Mice
Marine Drugs,
Год журнала:
2024,
Номер
22(10), С. 469 - 469
Опубликована: Окт. 12, 2024
In
this
study,
we
investigated
the
protective
effects
of
astaxanthin
(AST)
against
oxidative
stress
induced
by
combination
azoxymethane
(AOM)
and
dextran
sulfate
sodium
(DSS)
in
colitis-associated
cancer
(CAC)
TNF-α-induced
human
colorectal
cells
(SW480),
as
well
underlying
mechanism.
vitro
experiments
revealed
that
reduced
reactive
oxygen
species
(ROS)
generation
inhibited
expression
Phosphorylated
JNK
(P-JNK),
ERK
(P-ERK),
p65
(P-p65),
NF-κB
downstream
protein
cyclooxygenase-2
(COX-2).
vivo
showed
ameliorated
AOM/DSS-induced
weight
loss,
shortened
colon
length,
caused
histomorphological
changes.
addition,
suppressed
cellular
inflammation
modulating
MAPK
pathways
inhibiting
proinflammatory
cytokines
IL-6,
IL-1β,
TNF-α.
conclusion,
attenuates
CAC
through
its
antioxidant
effects.
Язык: Английский
The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review
Chunhao Gao,
Ni Gong,
Fangtian Chen
и другие.
Marine Drugs,
Год журнала:
2024,
Номер
23(1), С. 9 - 9
Опубликована: Дек. 27, 2024
Metabolic
syndrome
(MS)
represents
a
complex
cluster
of
metabolic
disorders
primarily
characterized
by
obesity,
insulin
resistance,
hyperglycemia,
dyslipidemia,
hypertension,
and
hyperuricemia.
Diet
functional
ingredients
play
pivotal
role
in
seeking
non-pharmacological
strategies
to
prevent
ameliorate
MS.
Astaxanthin
(AST),
carotenoid
found
various
marine
organisms,
exhibits
exceptional
antioxidant
properties
holds
great
promise
as
natural
compound
that
improves
This
article
introduces
the
basic
AST,
including
its
absorptance
pathways,
along
with
isomers.
Most
importantly,
we
comprehensively
review
effects
mechanisms
AST
on
improving
primary
components
These
involve
regulating
signal
transduction,
transport,
or
pathways
within
body,
well
influencing
intestinal
microbiota
metabolites,
thereby
exerting
positive
metabolism
inhibiting
occurrence
emphasizes
potential
efficacy
managing
However,
more
studies
are
needed
confirm
clinical
effect
MS
reveal
molecular
mechanisms.
Язык: Английский
Nutritional Strategies for Chronic Craniofacial Pain and Temporomandibular Disorders: Current Clinical and Preclinical Insights
Nutrients,
Год журнала:
2024,
Номер
16(17), С. 2868 - 2868
Опубликована: Авг. 27, 2024
This
narrative
review
provides
an
overview
of
current
knowledge
on
the
impact
nutritional
strategies
chronic
craniofacial
pain
associated
with
temporomandibular
disorders
(TMDs).
Individuals
experiencing
painful
TMDs
alter
their
dietary
habits,
avoiding
certain
foods,
possibly
due
to
chewing
difficulties,
which
might
lead
nutrient
deficiencies.
Our
literature
investigation
revealed
that
causal
links
between
changes
and
remain
unclear.
However,
clinical
preclinical
studies
suggest
nutraceuticals,
including
vitamins,
minerals,
polyphenols,
omega-3
fatty
acids,
isoprenoids,
carotenoids,
lectins,
polysaccharides,
glucosamines,
palmitoylethanolamides,
could
have
beneficial
effects
managing
TMDs.
is
described
in
12
38
articles
since
2000.
Clinical
discussed
roles
glucosamine,
palmitoylethanolamides.
The
other
nutraceuticals
were
assessed
solely
studies,
using
TMD
models,
mostly
inflammatory
rodents,
36
published
2013.
indicates
evidence
insufficient
assess
efficacy
these
nutraceuticals.
existing
data
potential
for
therapeutic
intervention
Further
support
from
longitudinal
randomized
controlled
well-designed
investigations
necessary
evaluate
each
nutraceutical
understand
underlying
mechanisms
Язык: Английский