Pomegranate Extracts as Dual Regulators of Angiogenesis: A Systematic Review of Preclinical Evidence in Cancer and Chronic Wound Healing DOI Creative Commons
Anna E. Caprifico, G Calabrese,

Riccardo Tornese

и другие.

Molecular Nutrition & Food Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

ABSTRACT Angiogenesis plays a critical role in both tumor progression and wound healing. This systematic review investigates the effect of pomegranate ( Punica granatum , PG) extracts as anti‐ pro‐angiogenic agents preclinical models cancer chronic healing (CWH), respectively. Following PRISMA guidelines, 14 studies (10 cancer, 4 CWH) were identified from PubMed, Scopus, Google Scholar databases. In models, PG (juice, peel extract, seed oil) reduced vascular endothelial growth factor (VEGF) expression, tube formation across multiple types, with concomitant decrease matrix metalloproteinases inflammatory mediators. Conversely, CWH topical extract applications enhanced VEGF expression closure diabetic burn injuries. dual angiogenic appears mechanistically linked to peroxisome proliferator‐activated receptor signaling pathways synergistic interactions among polyphenols, particularly ellagitannins. Assessment study quality revealed generally low risk bias vitro studies, while animal demonstrated variable methodological rigor. Despite promising evidence, standardization extraction methods, exploration molecular mechanisms, translation clinical investigations remain research priorities. comprehensive analysis validates therapeutic strategy for inhibiting pathological angiogenesis promoting beneficial CWH.

Язык: Английский

Pomegranate Extracts as Dual Regulators of Angiogenesis: A Systematic Review of Preclinical Evidence in Cancer and Chronic Wound Healing DOI Creative Commons
Anna E. Caprifico, G Calabrese,

Riccardo Tornese

и другие.

Molecular Nutrition & Food Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

ABSTRACT Angiogenesis plays a critical role in both tumor progression and wound healing. This systematic review investigates the effect of pomegranate ( Punica granatum , PG) extracts as anti‐ pro‐angiogenic agents preclinical models cancer chronic healing (CWH), respectively. Following PRISMA guidelines, 14 studies (10 cancer, 4 CWH) were identified from PubMed, Scopus, Google Scholar databases. In models, PG (juice, peel extract, seed oil) reduced vascular endothelial growth factor (VEGF) expression, tube formation across multiple types, with concomitant decrease matrix metalloproteinases inflammatory mediators. Conversely, CWH topical extract applications enhanced VEGF expression closure diabetic burn injuries. dual angiogenic appears mechanistically linked to peroxisome proliferator‐activated receptor signaling pathways synergistic interactions among polyphenols, particularly ellagitannins. Assessment study quality revealed generally low risk bias vitro studies, while animal demonstrated variable methodological rigor. Despite promising evidence, standardization extraction methods, exploration molecular mechanisms, translation clinical investigations remain research priorities. comprehensive analysis validates therapeutic strategy for inhibiting pathological angiogenesis promoting beneficial CWH.

Язык: Английский

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