Development of Nanomaterials‐Based Agents for Selective Antibacterial Activity DOI
Navjot Kaur,

Jagabandhu Sahoo,

Mrinmoy De

и другие.

ChemBioChem, Год журнала: 2024, Номер 26(1)

Опубликована: Дек. 5, 2024

Abstract Bacterial infections continue to threaten public health due limitations in rapid and accurate diagnostic techniques. While broad‐spectrum antibiotics offer empirical treatment, their overuse has fuelled the emergence of antimicrobial resistance (AMR) pathogens, posing a critical global challenge. In this scenario, nanomaterial‐based antibacterial agents emerge as promising solution combat bacteria inhibit proliferation. However, selective elimination pathogenic is paramount. This review highlights recent advancements developing nanomaterials for activity. We categorize these based on mode action, exploring how they selectively interact with potential mechanisms. offers crucial insights researchers nanotechnology address growing threat AMR.

Язык: Английский

Network Analysis as a Method for Identifying Operational Modes of Cold Atmospheric Plasma Jets DOI Creative Commons

Blake Haist,

Richard E. Wirz

Plasma, Год журнала: 2025, Номер 8(1), С. 10 - 10

Опубликована: Март 10, 2025

Network analysis is a convenient method for analyzing cold atmospheric plasma (CAP) devices across wide range of operating conditions. By using frequency and voltage as nodes in the network, edges are formed between when combination results an ignited jet. Singular value decomposition used to identify modalities network that representative operational modes An spectra produced by jet provides validation shows predominately affect operation with remarkable independence.

Язык: Английский

Процитировано

0

Voltage Dependent Effect of Spiral Wound Plasma Discharge on DBC1.2 Cellular Integrity DOI Creative Commons
Abubakar Hamza Sadiq, Md Jahangir Alam, Mahedi Hasan

и другие.

Plasma, Год журнала: 2025, Номер 8(2), С. 15 - 15

Опубликована: Апрель 12, 2025

Low temperature plasmas (LTPs) generated at atmospheric pressure and room have gained increasing attention in biomedical research due to their ability control cellular behavior through the production of reactive oxygen nitrogen species (RONS), electric fields, UV radiation. Among several LTP configurations, dielectric barrier discharge (DBD) plasma has been extensively studied for its stimulate controlled biological effects while maintaining low gas temperature, making it suitable cell-based applications. This study designed a novel spiral-wound DBD device investigate voltage-dependent on DBC1.2 epithelial cells. Plasma was applied 2 kVp-p, 3 4 kVp-p evaluate effect permeability, mitochondrial activity, viability, apoptosis. FITC-dextran-70 (FD-70, MW: 70 kDa) used as model permeation marker assess uptake. The results showed increase FD-70 uptake, suggesting improved plasma-assisted drug delivery. cell evaluated with MT-1 MitoMP detection kit, revealed that exposure slightly enhanced membrane potential (MMP), signifying increased metabolic whereas led reduction MMP, oxidative stress early Early late apoptosis further assessed using FITC Annexin-V propidium iodide (PI). viability reduced apoptotic when compared control. However, kV, there decline an apoptosis, shift towards plasma-induced cytotoxicity. established safe threshold cells explored use applications, particularly delivery modulation.

Язык: Английский

Процитировано

0

Improving osteogenic properties of zirconia ceramic via glow discharge plasma-enhanced deposition of amine organic compound DOI Creative Commons
Lwin Moe Aung, Ting‐Yi Renn,

Jerry Chin-Yi Lin

и другие.

Journal of Dental Sciences, Год журнала: 2024, Номер 20(1), С. 178 - 188

Опубликована: Авг. 29, 2024

Osseointegration potential is greatly depended on the interaction between bone cells and dental implant surface. Since zirconia ceramic has a bioinert surface, functionalization of surface with an organic compound allylamine was conducted to overcome its drawback minimal surrounding bone. The initially treated argon glow discharge plasma (GDP), then combined amine at three different conditions 50-W, 75-W 85-W, prepare final samples. characteristics cell biocompatibility were evaluated. Surface morphology analysis revealed bulbous pattern allylamine-treated sample groups. aromatic C-H, C-O, N-H, C ˆ C, C-H stretching functional groups have been identified. roughness increased, hydrophilicity improved after modification. Cell viability showed highest result for 50-W (A50) group. Alkaline phosphatase (ALP) assay indicated A50 group had activity, subsequently promoting late-stage mineralization day 21. reverse transcription-quantitative polymerase chain reaction (RT-qPCR) data demonstrated significant upregulation osteogenic gene expressions from 1 demonstrates immense enhancement in as well viability, differentiation, properties osteoblast-like cells. This makes it promising candidate future applications.

Язык: Английский

Процитировано

1

Development of Nanomaterials‐Based Agents for Selective Antibacterial Activity DOI
Navjot Kaur,

Jagabandhu Sahoo,

Mrinmoy De

и другие.

ChemBioChem, Год журнала: 2024, Номер 26(1)

Опубликована: Дек. 5, 2024

Abstract Bacterial infections continue to threaten public health due limitations in rapid and accurate diagnostic techniques. While broad‐spectrum antibiotics offer empirical treatment, their overuse has fuelled the emergence of antimicrobial resistance (AMR) pathogens, posing a critical global challenge. In this scenario, nanomaterial‐based antibacterial agents emerge as promising solution combat bacteria inhibit proliferation. However, selective elimination pathogenic is paramount. This review highlights recent advancements developing nanomaterials for activity. We categorize these based on mode action, exploring how they selectively interact with potential mechanisms. offers crucial insights researchers nanotechnology address growing threat AMR.

Язык: Английский

Процитировано

0