Collagen Extraction from Animal Skin

Biology, Год журнала: 2022, Номер 11(6), С. 905 - 905

Опубликована: Июнь 13, 2022

Collagen is the most abundant structural protein in animals. It major component of skin. finds uses cosmetics, medicine, yarn production and packaging. This paper reviews extraction collagen from hides consumed animals for meat with focus on literature published since 2000. The different pretreatment techniques that have been investigated producing animal skins are reviewed. Pretreatment by enzymatic, acid or alkaline methods used. Extraction chemical hydrolysis, salt solubilization, enzymatic ultrasound assisted other described. Post-extraction purification also explained. compilation will be useful anyone wishing to use as a resource wanting further improve methods.

Язык: Английский

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Nanoparticle protein corona: from structure and function to therapeutic targeting

Lab on a Chip, Год журнала: 2023, Номер 23(6), С. 1432 - 1466

Опубликована: Янв. 1, 2023

Representation of the influence biological and nanoscale factors on protein corona conformation function in a healthy versus pathogenic environment.

Язык: Английский

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Collagen Derived from Fish Industry Waste: Progresses and Challenges

Polymers, Год журнала: 2023, Номер 15(3), С. 544 - 544

Опубликована: Янв. 20, 2023

Fish collagen garnered significant academic and commercial focus in the last decades featuring prospective applications a variety of health-related industries, including food, medicine, pharmaceutics, cosmetics. Due to its distinct advantages over mammalian-based collagen, reduced zoonosis transmission risk, absence cultural-religious limitations, cost-effectiveness manufacturing process, superior bioavailability, use derived from fish wastes (i.e., skin, scales) quickly expanded. Moreover, by-products are low cost need minimize industry waste’s environmental impact paved way for discards development collagen-based products with remarkable added value. This review summarizes recent advances valorization extraction used several applications. Issues related processing characterization were presented. an overview most relevant food industry, nutraceutical, cosmetics, tissue engineering, packaging three years was introduced. Lastly, fish-collagen market open technological challenges reliable recovery exploitation this biopolymer discussed.

Язык: Английский

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Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver

Nature, Год журнала: 2024, Номер 626(7999), С. 635 - 642

Опубликована: Янв. 31, 2024

Abstract Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development 1,2 , and increased stiffness known promote HCC progression cirrhotic conditions 3,4 . characterized by an accumulation of advanced glycation end-products (AGEs) the ECM; however, how this affects non-cirrhotic unclear. Here we find that, patients animal models, AGEs changes collagen architecture enhance ECM viscoelasticity, with greater viscous dissipation faster stress relaxation, but not stiffness. High viscoelasticity combined oncogenic β-catenin signalling induction, whereas inhibiting AGE production, reconstituting clearance receptor AGER1 or breaking AGE-mediated cross-links reduces growth. Matrix analysis computational modelling demonstrate that lower interconnectivity AGE-bundled matrix, marked shorter fibre length heterogeneity, enhances viscoelasticity. Mechanistically, studies 3D cell cultures show enhanced promotes proliferation invasion through integrin-β1–tensin-1–YAP mechanotransductive pathway. These results reveal structural can vivo, independent

Язык: Английский

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Use of biopolymers in wastewater treatment: A brief review of current trends and prospects

Chinese Journal of Chemical Engineering, Год журнала: 2023, Номер 64, С. 292 - 320

Опубликована: Авг. 24, 2023

Язык: Английский

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From hemostasis to proliferation: Accelerating the infected wound healing through a comprehensive repair strategy based on GA/OKGM hydrogel loaded with MXene@TiO2 nanosheets

Biomaterials, Год журнала: 2024, Номер 308, С. 122548 - 122548

Опубликована: Март 27, 2024

Язык: Английский

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Tissue engineering applications of recombinant human collagen: a review of recent progress

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Фев. 14, 2024

With the rapid development of synthetic biology, recombinant human collagen has emerged as a cutting-edge biological material globally. Its innovative applications in fields science and medicine have opened new horizons biomedical research. Recombinant stands out highly promising biomaterial, playing pivotal role crucial areas such wound healing, stroma regeneration, orthopedics. However, realizing its full potential by efficiently delivering it for optimal therapeutic outcomes remains formidable challenge. This review provides comprehensive overview systems, focusing on resolving this issue. Additionally, encompasses exploration 3D printing technologies incorporating to address some urgent clinical challenges regenerative repair future. The primary aim also is spotlight advancements realm biomaterials utilizing collagen, with intention fostering additional innovation making significant contributions enhancement biomaterials, methodologies, overall patient outcomes.

Язык: Английский

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Application of collagen in bone regeneration

Journal of Orthopaedic Translation, Год журнала: 2025, Номер 50, С. 129 - 143

Опубликована: Янв. 1, 2025

At present, there is a significant population of individuals experiencing bone deficiencies caused by injuries, ailments affecting the bones, congenital abnormalities, and cancer. The management substantial defects global orthopedic challenge due to intricacies involved in promoting restoring growth fresh osseous tissue. Autografts are widely regarded as "gold standard" for repairing because their superior tissue acceptance ability control osteogenesis. However, patients undergoing autografts may encounter various challenges, including but not limited hernia, bleeding, nerve impairment, death. Therefore, researchers regenerative medicine striving find alternatives. Collagen most abundant protein human body, its triple helix structure gives it unique characteristics that contribute strength functionality tissues. commonly processed into forms such scaffolds, sponges, membranes, hydrogels, composite materials, compatibility with affinity water, minimal potential immune reactions, adaptability, transport nutrients or drugs. As an alternative material field regeneration, collagen becoming increasingly important. objective this review provide comprehensive analysis primary types sources collagen, processes synthesis degradation, well advancements made regeneration research applications. A investigation role undertaken, providing valuable points reference more profound comprehension applications field. concluding section provides overview prospective avenues research, underscoring promising future highlighting regeneration. Translational Potential Article. exploration diverse functions translational demonstrated review, these findings underscore treatment option clinical implications, thus paving way innovative efficacious therapeutic strategies domain.

Язык: Английский

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Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10

Опубликована: Март 1, 2022

With the development of three-dimensional (3D) printed technology, 3D alloy implants, especially titanium alloy, play a critical role in biomedical fields such as orthopedics and dentistry. However, untreated implants always possess bioinert surface that prevents interface osseointegration, which is necessary to perform modification enhance its biological functions. In this article, we discuss principles processes chemical, physical, technologies on detail. Furthermore, challenges antibacterial, osteogenesis, mechanical properties 3D-printed by are summarized. Future research studies, including combination multiple or coordination structure composition composite coating also present. This review provides leading-edge functionalization strategies implants.

Язык: Английский

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Sustainable Approach of Functional Biomaterials–Tissue Engineering for Skin Burn Treatment: A Comprehensive Review

Pharmaceuticals, Год журнала: 2023, Номер 16(5), С. 701 - 701

Опубликована: Май 5, 2023

Burns are a widespread global public health traumatic injury affecting many people worldwide. Non-fatal burn injuries leading cause of morbidity, resulting in prolonged hospitalization, disfigurement, and disability, often with stigma rejection. The treatment burns is aimed at controlling pain, removing dead tissue, preventing infection, reducing scarring risk, tissue regeneration. Traditional wound methods include the use synthetic materials such as petroleum-based ointments plastic films. However, these can be associated negative environmental impacts may not biocompatible human body. Tissue engineering has emerged promising approach to treating burns, sustainable biomaterials have been developed an alternative option. Green collagen, cellulose, chitosan, others biocompatible, biodegradable, environment-friendly, cost-effective, which reduces impact their production disposal. They effective promoting healing risk infection other benefits inflammation angiogenesis. This comprehensive review focuses on multifunctional green that potential revolutionize way we treat skin faster more efficient while minimizing damage.

Язык: Английский

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