Thermally-responsive and reduced glutathione-sensitive folate-targeted nanocarrier based on alginate and pluronic F127 for on-demand release of methotrexate

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 263, С. 130227 - 130227

Опубликована: Фев. 18, 2024

Язык: Английский

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Improvement of the dissolution of the antineoplastic drug regorafenib through impregnation into pullulan polysaccharide using supercritical fluid technology: Optimization of the process

Journal of CO2 Utilization, Год журнала: 2025, Номер 93, С. 103040 - 103040

Опубликована: Фев. 9, 2025

Язык: Английский

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Effects of Particle Geometry for PLGA-Based Nanoparticles: Preparation and In Vitro/In Vivo Evaluation

Pharmaceutics, Год журнала: 2023, Номер 15(1), С. 175 - 175

Опубликована: Янв. 3, 2023

The physicochemical properties (size, shape, zeta potential, porosity, elasticity, etc.) of nanocarriers influence their biological behavior directly, which may result in alterations the therapeutic outcome. Understanding effect shape on cellular interaction and biodistribution intravenously injected particles could have fundamental importance for rational design drug delivery systems. In present study, spherical, rod elliptical disk-shaped PLGA nanoparticles were developed examining systematically vitro vivo. An important finding is that release encapsulated human serum albumin (HSA) was significantly higher spherical compared to disks, indicating can make a difference. Safety studies showed toxicity not dependent studied concentration range. This study has pioneering findings comparing terms particle size, size distribution, colloidal stability, morphology, encapsulation, release, safety nanoparticles, uptake biodistribution. Nude mice bearing non-small cell lung cancer treated with 3 differently shaped accumulation tumor tissue other organs statistically different (p > 0.05). It found 1.00, 4.0 ± 0.5, 7.5 0.5 aspect ratios did differ total cancer.

Язык: Английский

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Supramolecular biomaterials as drug nanocontainers with iron depletion properties for antimicrobial applications

Materials Advances, Год журнала: 2024, Номер 5(9), С. 3675 - 3682

Опубликована: Янв. 1, 2024

This work reports the design of a new bacteria-killer based on maltol derivatives and β-cyclodextrin cryogels.

Язык: Английский

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CMC/Starch/SiO2/ GQDs nanoemulsion for targeted delivery of 5-fluorouracil

Journal of Molecular Liquids, Год журнала: 2024, Номер 408, С. 125407 - 125407

Опубликована: Авг. 1, 2024

Язык: Английский

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Formulation and evaluation of red fruit (Pandanus conoideus) oil-based nanoemulsion loaded thermosensitive gel combined with solid microneedle for topical delivery

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 96, С. 105707 - 105707

Опубликована: Апрель 30, 2024

Язык: Английский

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Acrylate and Methacrylate Polymers’ Applications: Second Life with Inexpensive and Sustainable Recycling Approaches

Materials, Год журнала: 2021, Номер 15(1), С. 282 - 282

Опубликована: Дек. 31, 2021

Polymers are widely employed in several fields thanks to their wide versatility and the easy derivatization routes. However, a range of commercial polymers suffer from limited use on large scale due inert nature. Nowadays, acrylate methacrylate polymers, which respectively derivatives acrylic or methacrylic acid, among most proposed materials for useful characteristics like good biocompatibility, capping ability toward metal clusters, low price, potentially recyclability reusability. Here, we discuss advantages challenges this class smart focusing our attention current technological applications medical, electronic, food packaging environmental remediation fields. Furthermore, deal with main issue recyclability, considering that bioplastics not yet able meet global needs as much totally replace fossil-fuel-based products. Finally, accredited strategies reach recyclable composites based described.

Язык: Английский

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Injectable bone cement containing carboxymethyl cellulose microparticles as a silver delivery system able to reduce implant-associated infection risk

Acta Biomaterialia, Год журнала: 2022, Номер 145, С. 342 - 357

Опубликована: Апрель 14, 2022

Язык: Английский

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An antibacterial nanoclay- and chitosan-based quad composite with controlled drug release for infected skin wound healing

Carbohydrate Polymers, Год журнала: 2023, Номер 324, С. 121507 - 121507

Опубликована: Окт. 17, 2023

Язык: Английский

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Enhanced transdermal delivery of apremilast loaded ethosomes: Optimization, characterization and in vivo evaluation

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 91, С. 105211 - 105211

Опубликована: Ноя. 29, 2023

Язык: Английский

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