Folic-Acid-Conjugated Poly (Lactic-Co-Glycolic Acid) Nanoparticles Loaded with Gallic Acid Induce Glioblastoma Cell Death by Reactive-Oxygen-Species-Induced Stress DOI Open Access
Maria João Ramalho, B. R. C. Alves, Stéphanie Andrade

и другие.

Polymers, Год журнала: 2024, Номер 16(15), С. 2161 - 2161

Опубликована: Июль 30, 2024

Glioblastoma (GBM) conventional treatment is not curative, and it associated with severe toxicity. Thus, natural compounds anti-cancer properties lower systemic toxicity, such as gallic acid (GA), have been explored alternatives. However, GA’s therapeutic effects are limited due to its rapid metabolism, low bioavailability, permeability across the blood–brain barrier (BBB). This work aimed develop poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) modified folic (FA), receptor overexpressed in BBB GBM cells, for GA delivery enhance efficacy. The preparation of NPs was optimized by a central composite design (CCD). obtained showed physicochemical features suitable drug internalization tumor cells (sizes below 200 nm, monodispersity, negative surface charge) ability maintain slow sustained release 40 days. In vitro studies using human cell line (U215) revealed NPs’ accumulate target further promoting antiproliferative activity inducing production intracellular reactive oxygen species (ROS). Furthermore, encapsulation developed nanosystems conferred higher protection healthy cells.

Язык: Английский

Neurotrophic factor-based pharmacological approaches in neurological disorders DOI Creative Commons
Vanessa Castelli, Margherita Alfonsetti, Michele d’Angelo

и другие.

Neural Regeneration Research, Год журнала: 2022, Номер 18(6), С. 1220 - 1220

Опубликована: Окт. 14, 2022

Aging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading cognitive decline. This process represents the major risk factor for aging-related diseases such as Alzheimer's disease, Parkinson's ischemic stroke. The incidence of all these pathologies increases exponentially with age. Research aging biology has currently focused elucidating molecular mechanisms development those pathologies. Cognitive deficit neurodegeneration, common features pathologies, related alteration activity levels neurotrophic factors, brain-derived factor, nerve growth glial cell-derived factor. For this reason, treatments modulate neurotrophin have acquired great deal interest in preventing neurodegeneration promoting neural regeneration several neurological diseases. Those include both direct administration factors induced expression viral vectors, neurotrophins' binding biomaterials or other molecules increase their bioavailability but also cell-based therapies. Considering crucial role here we discuss involvement most brain recent therapeutic approaches provide sustained support.

Язык: Английский

Процитировано

19

Evolution of lipid nanoparticles as charioteers of Alzheimer's disease therapeutics DOI

Brati Chakraborty,

Gayatri Patel, Bandana Padhan

и другие.

Applied Materials Today, Год журнала: 2024, Номер 41, С. 102442 - 102442

Опубликована: Сен. 23, 2024

Язык: Английский

Процитировано

4

Inflammation‐Responsive Functional Core–Shell Micro‐Hydrogels Promote Rotator Cuff Tendon‐To‐Bone Healing by Recruiting MSCs and Immuno‐Modulating Macrophages in Rats DOI
B. Chen, Xin Zhao,

Meiguang Xu

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Rotator cuff injuries often necessitate surgical intervention, but the outcomes are unsatisfactory. The underlying reasons can be attributed to multiple factors, with intricate inflammatory activities and insufficient presence of stem cells being particularly significant. In this study, an innovative inflammation-responsive core-shell micro-hydrogel is designed for independent release SDF-1 IL-4 within a single delivery system promote tendon-to-bone healing by recruiting MSCs modulating M2 macrophages polarization. First, MMP-2 responsive hydrogel loaded (GelMA-MMP/IL-4) synthesized cross-linking gelatin methacrylate (GelMA) substrate peptide. Then, resulting core particles coated shell chitosan /SDF-1/hyaluronic acid (CS/HA/SDF-1) using layer-by-layer electrostatic deposition method form composite. shows sustained MMP-2-responsive associated in situ homing smart inflammation regulation promoting Additionally, injecting these micro-hydrogels into rat rotator tear repair model, notable improvements fibrocartilage layer observed between tendon bone. Notably, study presents new potentially powerful environment-responsive drug strategy that offers valuable insights regulating micro-environment tissue regeneration.

Язык: Английский

Процитировано

4

PLGA Cage‐Like Structures Loaded with Sr/Mg‐Doped Hydroxyapatite for Repairing Osteoporotic Bone Defects DOI

Shangke Yu,

Tong Sun, Wei Liu

и другие.

Macromolecular Bioscience, Год журнала: 2022, Номер 22(8)

Опубликована: Май 30, 2022

Poly(lactic-co-glycolic acid) (PLGA)-based porous structures have a widespread application in bone defects. To solve its flaws the application, hydroxyapatite (HA) is often introduced into PLGA-based systems, and ion doping endows HA with more biological activity. In osteoporotic defects, decreased activity of osteoblasts hyperactive osteoclasts results slow repair. Strontium (Sr) can promote regeneration inhibit resorption has been used treatment osteoporosis. Magnesium (Mg) cannot only enhance tissue but also vessels. this study,the aim to fabricate multifunctional structure that osteogenesis, angiogenesis for repairing PLGA cage-like loaded Sr- Mg-doped (Sr/Mg@HA/PLGA-CAS) are prepared; they large pores, suitable hydrophilicity, continuously release Mg2+ Sr2+ , which facilitate cell adhesion growth. The show Sr/Mg@HA/PLGA-CAS motivate osteogenic osteoblast precursor cells angiogenic ability endothelial cells, suppress osteoclast differentiation vitro. This study indicates assist while restraining differentiation, may potential value

Язык: Английский

Процитировано

15

A Review of the Potential of Poly-(lactide-co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-Methyljuglone DOI Creative Commons
Bianca Diedericks,

Anna-Mari Kok,

Vusani Mandiwana

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 216 - 216

Опубликована: Фев. 1, 2024

7-Methyljuglone (7-MJ) is a pure compound isolated from the roots of Euclea natalensis A. DC., shrub indigenous to South Africa. It exhibits significant promise as potential treatment for highly communicable disease tuberculosis (TB), owing its effective antimycobacterial activity against Mycobacterium tuberculosis. Despite therapeutic benefits, 7-MJ has demonstrated in vitro cytotoxicity various cancerous and non-cancerous cell lines, raising concerns about safety consumption by TB patients. Therefore, this review focuses on exploring poly-(lactide-co-glycolic) acid (PLGA) nanoparticles delivery system, which been shown decrease cytotoxicity, an compound.

Язык: Английский

Процитировано

3

From hard tissues to beyond: Progress and challenges of strontium-containing biomaterials in regenerative medicine applications DOI
Liyun Wang, Shengjie Jiang, Jialiang Zhou

и другие.

Bioactive Materials, Год журнала: 2025, Номер 49, С. 85 - 120

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

0

Microfluidic Construction of Heterogeneous Micro–Nano-Structured Materials for Biomedical Applications DOI
Xiaowei Yang, Chaojing Li,

Yongjie Jiao

и другие.

ACS Materials Letters, Год журнала: 2025, Номер unknown, С. 1462 - 1487

Опубликована: Март 20, 2025

Язык: Английский

Процитировано

0

Refining nanoprobes for monitoring of inflammatory bowel disease DOI

Ruchen Yao,

Mingming Zhu,

Zhiqian Guo

и другие.

Acta Biomaterialia, Год журнала: 2024, Номер 177, С. 37 - 49

Опубликована: Фев. 15, 2024

Язык: Английский

Процитировано

2

Organic Nanoparticles in Progressing Cardiovascular Disease Treatment and Diagnosis DOI Open Access
Alexandru Scafa‐Udriște,

Alexandra Cristina Burdușel,

Adelina-Gabriela Niculescu

и другие.

Polymers, Год журнала: 2024, Номер 16(10), С. 1421 - 1421

Опубликована: Май 16, 2024

Cardiovascular diseases (CVDs), the world’s most prominent cause of mortality, continue to be challenging conditions for patients, physicians, and researchers alike. CVDs comprise a wide range illnesses affecting heart, blood vessels, that flows through between them. Advances in nanomedicine, discipline focused on improving patient outcomes revolutionary treatments, imaging agents, ex vivo diagnostics, have created enthusiasm overcoming limitations CVDs’ therapeutic diagnostic landscapes. Nanomedicine can involved clinical purposes CVD augmentation cardiac or heart-related biomaterials, which functionally, mechanically, immunologically, electrically improved by incorporating nanomaterials; vasculature applications, involve systemically injected nanotherapeutics nanodiagnostics, nano-enabled tissue-nanoengineered solutions; enhancement sensitivity and/or specificity devices samples. Therefore, this review discusses latest studies based applying organic nanoparticles cardiovascular illness, including drug-conjugated polymers, lipid nanoparticles, micelles. Following revised information, it concluded may appropriate type treatment due their biocompatibility capacity integrate various drugs.

Язык: Английский

Процитировано

2

Designing Dual-Responsive Drug Delivery Systems: The Role of Phase Change Materials and Metal–Organic Frameworks DOI Open Access
Wanying Wei, Ping Lü

Materials, Год журнала: 2024, Номер 17(13), С. 3070 - 3070

Опубликована: Июнь 22, 2024

Stimuli-responsive drug delivery systems (DDSs) offer precise control over release, enhancing therapeutic efficacy and minimizing side effects. This review focuses on DDSs that leverage the unique capabilities of phase change materials (PCMs) metal-organic frameworks (MOFs) to achieve controlled release in response pH temperature changes. Specifically, this highlights use a combination lauric stearic acids as PCMs melt slightly above body temperature, providing thermally responsive mechanism for release. Additionally, delves into properties zeolitic imidazolate framework-8 (ZIF-8), stable MOF under physiological conditions decomposes acidic environments, thus offering pH-sensitive capabilities. The integration these enables fabrication complex structures encapsulate drugs within ZIF-8 or are enveloped by PCM layers, ensuring is tightly either levels, both. provides comprehensive insights core design principles, material selections, potential biomedical applications dual-stimuli DDSs, highlighting future directions challenges innovative field.

Язык: Английский

Процитировано

2