Polymers,
Год журнала:
2024,
Номер
16(15), С. 2161 - 2161
Опубликована: Июль 30, 2024
Glioblastoma
(GBM)
conventional
treatment
is
not
curative,
and
it
associated
with
severe
toxicity.
Thus,
natural
compounds
anti-cancer
properties
lower
systemic
toxicity,
such
as
gallic
acid
(GA),
have
been
explored
alternatives.
However,
GA’s
therapeutic
effects
are
limited
due
to
its
rapid
metabolism,
low
bioavailability,
permeability
across
the
blood–brain
barrier
(BBB).
This
work
aimed
develop
poly
(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
(NPs)
modified
folic
(FA),
receptor
overexpressed
in
BBB
GBM
cells,
for
GA
delivery
enhance
efficacy.
The
preparation
of
NPs
was
optimized
by
a
central
composite
design
(CCD).
obtained
showed
physicochemical
features
suitable
drug
internalization
tumor
cells
(sizes
below
200
nm,
monodispersity,
negative
surface
charge)
ability
maintain
slow
sustained
release
40
days.
In
vitro
studies
using
human
cell
line
(U215)
revealed
NPs’
accumulate
target
further
promoting
antiproliferative
activity
inducing
production
intracellular
reactive
oxygen
species
(ROS).
Furthermore,
encapsulation
developed
nanosystems
conferred
higher
protection
healthy
cells.
Neural Regeneration Research,
Год журнала:
2022,
Номер
18(6), С. 1220 - 1220
Опубликована: Окт. 14, 2022
Aging
is
a
physiological
event
dependent
on
multiple
pathways
that
are
linked
to
lifespan
and
processes
leading
cognitive
decline.
This
process
represents
the
major
risk
factor
for
aging-related
diseases
such
as
Alzheimer's
disease,
Parkinson's
ischemic
stroke.
The
incidence
of
all
these
pathologies
increases
exponentially
with
age.
Research
aging
biology
has
currently
focused
elucidating
molecular
mechanisms
development
those
pathologies.
Cognitive
deficit
neurodegeneration,
common
features
pathologies,
related
alteration
activity
levels
neurotrophic
factors,
brain-derived
factor,
nerve
growth
glial
cell-derived
factor.
For
this
reason,
treatments
modulate
neurotrophin
have
acquired
great
deal
interest
in
preventing
neurodegeneration
promoting
neural
regeneration
several
neurological
diseases.
Those
include
both
direct
administration
factors
induced
expression
viral
vectors,
neurotrophins'
binding
biomaterials
or
other
molecules
increase
their
bioavailability
but
also
cell-based
therapies.
Considering
crucial
role
here
we
discuss
involvement
most
brain
recent
therapeutic
approaches
provide
sustained
support.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Rotator
cuff
injuries
often
necessitate
surgical
intervention,
but
the
outcomes
are
unsatisfactory.
The
underlying
reasons
can
be
attributed
to
multiple
factors,
with
intricate
inflammatory
activities
and
insufficient
presence
of
stem
cells
being
particularly
significant.
In
this
study,
an
innovative
inflammation-responsive
core-shell
micro-hydrogel
is
designed
for
independent
release
SDF-1
IL-4
within
a
single
delivery
system
promote
tendon-to-bone
healing
by
recruiting
MSCs
modulating
M2
macrophages
polarization.
First,
MMP-2
responsive
hydrogel
loaded
(GelMA-MMP/IL-4)
synthesized
cross-linking
gelatin
methacrylate
(GelMA)
substrate
peptide.
Then,
resulting
core
particles
coated
shell
chitosan
/SDF-1/hyaluronic
acid
(CS/HA/SDF-1)
using
layer-by-layer
electrostatic
deposition
method
form
composite.
shows
sustained
MMP-2-responsive
associated
in
situ
homing
smart
inflammation
regulation
promoting
Additionally,
injecting
these
micro-hydrogels
into
rat
rotator
tear
repair
model,
notable
improvements
fibrocartilage
layer
observed
between
tendon
bone.
Notably,
study
presents
new
potentially
powerful
environment-responsive
drug
strategy
that
offers
valuable
insights
regulating
micro-environment
tissue
regeneration.
Macromolecular Bioscience,
Год журнала:
2022,
Номер
22(8)
Опубликована: Май 30, 2022
Poly(lactic-co-glycolic
acid)
(PLGA)-based
porous
structures
have
a
widespread
application
in
bone
defects.
To
solve
its
flaws
the
application,
hydroxyapatite
(HA)
is
often
introduced
into
PLGA-based
systems,
and
ion
doping
endows
HA
with
more
biological
activity.
In
osteoporotic
defects,
decreased
activity
of
osteoblasts
hyperactive
osteoclasts
results
slow
repair.
Strontium
(Sr)
can
promote
regeneration
inhibit
resorption
has
been
used
treatment
osteoporosis.
Magnesium
(Mg)
cannot
only
enhance
tissue
but
also
vessels.
this
study,the
aim
to
fabricate
multifunctional
structure
that
osteogenesis,
angiogenesis
for
repairing
PLGA
cage-like
loaded
Sr-
Mg-doped
(Sr/Mg@HA/PLGA-CAS)
are
prepared;
they
large
pores,
suitable
hydrophilicity,
continuously
release
Mg2+
Sr2+
,
which
facilitate
cell
adhesion
growth.
The
show
Sr/Mg@HA/PLGA-CAS
motivate
osteogenic
osteoblast
precursor
cells
angiogenic
ability
endothelial
cells,
suppress
osteoclast
differentiation
vitro.
This
study
indicates
assist
while
restraining
differentiation,
may
potential
value
Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 216 - 216
Опубликована: Фев. 1, 2024
7-Methyljuglone
(7-MJ)
is
a
pure
compound
isolated
from
the
roots
of
Euclea
natalensis
A.
DC.,
shrub
indigenous
to
South
Africa.
It
exhibits
significant
promise
as
potential
treatment
for
highly
communicable
disease
tuberculosis
(TB),
owing
its
effective
antimycobacterial
activity
against
Mycobacterium
tuberculosis.
Despite
therapeutic
benefits,
7-MJ
has
demonstrated
in
vitro
cytotoxicity
various
cancerous
and
non-cancerous
cell
lines,
raising
concerns
about
safety
consumption
by
TB
patients.
Therefore,
this
review
focuses
on
exploring
poly-(lactide-co-glycolic)
acid
(PLGA)
nanoparticles
delivery
system,
which
been
shown
decrease
cytotoxicity,
an
compound.
Polymers,
Год журнала:
2024,
Номер
16(10), С. 1421 - 1421
Опубликована: Май 16, 2024
Cardiovascular
diseases
(CVDs),
the
world’s
most
prominent
cause
of
mortality,
continue
to
be
challenging
conditions
for
patients,
physicians,
and
researchers
alike.
CVDs
comprise
a
wide
range
illnesses
affecting
heart,
blood
vessels,
that
flows
through
between
them.
Advances
in
nanomedicine,
discipline
focused
on
improving
patient
outcomes
revolutionary
treatments,
imaging
agents,
ex
vivo
diagnostics,
have
created
enthusiasm
overcoming
limitations
CVDs’
therapeutic
diagnostic
landscapes.
Nanomedicine
can
involved
clinical
purposes
CVD
augmentation
cardiac
or
heart-related
biomaterials,
which
functionally,
mechanically,
immunologically,
electrically
improved
by
incorporating
nanomaterials;
vasculature
applications,
involve
systemically
injected
nanotherapeutics
nanodiagnostics,
nano-enabled
tissue-nanoengineered
solutions;
enhancement
sensitivity
and/or
specificity
devices
samples.
Therefore,
this
review
discusses
latest
studies
based
applying
organic
nanoparticles
cardiovascular
illness,
including
drug-conjugated
polymers,
lipid
nanoparticles,
micelles.
Following
revised
information,
it
concluded
may
appropriate
type
treatment
due
their
biocompatibility
capacity
integrate
various
drugs.
Materials,
Год журнала:
2024,
Номер
17(13), С. 3070 - 3070
Опубликована: Июнь 22, 2024
Stimuli-responsive
drug
delivery
systems
(DDSs)
offer
precise
control
over
release,
enhancing
therapeutic
efficacy
and
minimizing
side
effects.
This
review
focuses
on
DDSs
that
leverage
the
unique
capabilities
of
phase
change
materials
(PCMs)
metal-organic
frameworks
(MOFs)
to
achieve
controlled
release
in
response
pH
temperature
changes.
Specifically,
this
highlights
use
a
combination
lauric
stearic
acids
as
PCMs
melt
slightly
above
body
temperature,
providing
thermally
responsive
mechanism
for
release.
Additionally,
delves
into
properties
zeolitic
imidazolate
framework-8
(ZIF-8),
stable
MOF
under
physiological
conditions
decomposes
acidic
environments,
thus
offering
pH-sensitive
capabilities.
The
integration
these
enables
fabrication
complex
structures
encapsulate
drugs
within
ZIF-8
or
are
enveloped
by
PCM
layers,
ensuring
is
tightly
either
levels,
both.
provides
comprehensive
insights
core
design
principles,
material
selections,
potential
biomedical
applications
dual-stimuli
DDSs,
highlighting
future
directions
challenges
innovative
field.
