Polysaccharides based biopolymers for biomedical applications: A review

Polymers for Advanced Technologies, Год журнала: 2023, Номер 35(1)

Опубликована: Окт. 9, 2023

Abstract Polysaccharides are a class of natural biopolymers that have attracted significant attention due to their unique properties, which make them attractive for use in wide range applications. These an important role our daily life, and designing biomaterials biomedical applications requires careful consideration factors such as biocompatibility, biodegradability, renewability, affordability, availability, all can be achieved with polysaccharides. This review paper focuses on the polysaccharides provides in‐depth analysis potential arabinoxylan, type hemicellulose, various fields, including drug delivery, infection control, tissue engineering, wound healing, others. Arabinoxylan, is derived from plants, most abundant hemicellulose has diverse catalyst its renewable nature. Polysaccharide‐based covers, delivery systems, food preservation, biocomposite films, making emerging excipient pharmaceutical research. highlights polysaccharide‐based science suggests continued research development will lead broader more innovative field. The significantly advance healthcare improve patient outcomes.

Язык: Английский

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Silk Sericin and Its Composite Materials with Antibacterial Properties to Enhance Wound Healing: A Review

Biomolecules, Год журнала: 2024, Номер 14(6), С. 723 - 723

Опубликована: Июнь 18, 2024

Wound infections may disrupt the normal wound-healing process. Large amounts of antibiotics are frequently used to prevent pathogenic infections; however, this can lead resistance development. Biomaterials possessing antimicrobial properties have promising applications for reducing antibiotic usage and promoting wound healing. Silk sericin (SS) has been increasingly explored skin healing owing its excellent biocompatibility antioxidant, antimicrobial, ultraviolet-resistant properties. In recent years, SS-based composite biomaterials with a broader spectrum extensively investigated demonstrated favorable efficacy in This review summarizes various agents, including metal nanoparticles, natural extracts, antibiotics, that incorporated into SS composites elucidates their mechanisms action. It revealed achieve sustained activity by slow-release-loaded agents. The antimicrobial-loaded promote through anti-infection, anti-inflammation, hemostasis, angiogenesis, collagen deposition. manufacturing methods, benefits, limitations materials briefly discussed. aims enhance understanding new advances directions guide future biomedical research.

Язык: Английский

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Biodegradable PBAT/PLA blend films incorporated with turmeric and cinnamomum powder: A potential alternative for active food packaging

Food Chemistry, Год журнала: 2023, Номер 439, С. 138146 - 138146

Опубликована: Дек. 7, 2023

Язык: Английский

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From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Plants, Год журнала: 2023, Номер 12(14), С. 2661 - 2661

Опубликована: Июль 16, 2023

Transdermal delivery devices and wound dressing materials are constantly improved upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, cost effectiveness. Therefore, researchers in field have shown an increasing interest using natural compounds as constituents for such systems. Plants, important source so-called “natural products” enormous variety structural diversity that still exceeds capacity present-day sciences to define or even discover them, been part medicine since ancient times. However, benefits just at beginning being fully exploited modern dermal transdermal Thus, plant-based primary compounds, without biological activity, contained gums mucilages, traditionally used gelling texturing agents food industry, now explored valuable cost-effective components biomedical field. Their non-toxicity compensate local availability compositional variations. Also, secondary metabolites, classified based on chemical structure, intensively investigated wide pharmacological toxicological effects. impact is highlighted detail through most recent reported studies. Innovative isolation purification techniques, new drug systems, advanced evaluation procedures presented.

Язык: Английский

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Turmeric and Curcumin—Health-Promoting Properties in Humans versus Dogs

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(19), С. 14561 - 14561

Опубликована: Сен. 26, 2023

The growing popularity of the use nutraceuticals in prevention and alleviation symptoms many diseases humans dogs means that they are increasingly subject research. A representative nutraceutical deserves special attention is turmeric. Turmeric belongs to family Zingiberaceae grown extensively Asia. It a plant used as spice food coloring, it also traditional medicine. biologically active factors give turmeric its unusual properties color curcuminoids. group substances includes curcumin, de-methoxycurcumin, bis-demethoxycurcumin. Curcumin yellow-orange coloring. most important pro-health effects observed after taking curcuminoids include anti-inflammatory, anticancer, antioxidant effects. aim this study was characterize main substance, terms their properties, advantages, disadvantages, based on literature data.

Язык: Английский

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Advances in Functionalization of Bioresorbable Nanomembranes and Nanoparticles for Their Use in Biomedicine

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 10312 - 10312

Опубликована: Июнь 18, 2023

Bioresorbable nanomembranes (NMs) and nanoparticles (NPs) are powerful polymeric materials playing an important role in biomedicine, as they can effectively reduce infections inflammatory clinical patient conditions due to their high biocompatibility, ability physically interact with biomolecules, large surface area, low toxicity. In this review, the most common bioabsorbable such those belonging natural polymers proteins for manufacture of NMs NPs reviewed. addition biocompatibility bioresorption, current methodology on functionalization is also revisited recent applications highlighted. Considering use field biosensors, tethered lipid bilayers, drug delivery, wound dressing, skin regeneration, targeted chemotherapy imaging/diagnostics, functionalized have become one main pillars modern biomedical applications.

Язык: Английский

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Optimized production of carboxymethyl cellulose/guar gum based durable hydrogel for in vitro performance assessment

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135121 - 135121

Опубликована: Авг. 27, 2024

Язык: Английский

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Impact of Polymer Physicochemical Features on the Amorphization and Crystallization of Citric Acid in Solid Dispersions

Polymers, Год журнала: 2025, Номер 17(3), С. 310 - 310

Опубликована: Янв. 24, 2025

The amorphization and crystallization of citric acid in the presence a variety polymers were investigated. Polymers chosen for their different physicochemical features, including hygroscopicity, glass transition temperature (Tg), functional groups capable forming intermolecular non-covalent interactions with acid. Citric solutions varying amounts pectin (PEC), guar gum (GG), κ-carrageenan (KG), gelatin (GEL), (hydroxypropyl)methylcellulose (HPMC), carboxymethylcellulose sodium (CMC-Na) lyophilized. Dispersions stored up to 6 months controlled relative humidity environments periodically monitored using powder X-ray diffraction, differential scanning calorimetry, Fourier transform infrared spectroscopy. Moisture sorption isotherms moisture contents determined. Amorphous solid dispersions successfully formed ≥20% w/w CMC-Na PEC or ≥30% other except KG which required minimum 40% polymer. All samples remained amorphous even rubbery state at 0% RH (25 °C 40 °C), but increasing 32% resulted dispersions, further 54% all samples. Polymer effectiveness inhibiting was > ≥ GEL HPMC GG KG. To create maintain acid, polymer traits order as follows: greater propensity (both ionic hydrogen bonding) carbonyl groups, higher Tg, then lower hygroscopicity.

Язык: Английский

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3D Printed Film Containing Rhodomyrtus tomentosa Leaves Extract for Antibacterial, Anti-Inflammatory and Antioxidant Applications

Natural Product Communications, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

Background: Macroporous gels containing essential oil (EO) from Cinnamomum bejolghota have emerged as promising materials for biomedical applications due to the combinatory benefits of a highly porous structure and bioactive properties natural extracts. Objectives: Therefore, this study develops 3D printed macroporous gel incorporating EO C. leaf extract by using freeze-thaw method create interconnected pores. Methods: The samples were prepared mixing agar with at various concentrations (50, 100, 200 µmol/L) freezing −20 °C form network. as-synthesized was subjected SEM FTIR analysis, then investigated antibacterial anti-inflammatory activities. Results: images revealed that pore sizes ranged 1 2 µm, successful integration EO. Specifically, sample leaves µmol/L (Agar/EO200) exhibited most significant action against E. coli S. aureus, indicated inhibition zones radius 6.3 ± 0.26 mm 8.7 0.94 mm, respectively. Additionally, activity Agar/EO200 achieved 86.01% 0.43 nitric oxide (NO) inhibition, which outweighed other samples. Conclusion: These results suggest holds great potential multi-functional material wound healing applications.

Язык: Английский

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Antibacterial, antioxidant, and anti‐inflammatory surgical sutures fabricated by melt mixing of a polymer blend with curcumin‐loaded microspheres

Polymer Engineering and Science, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Abstract A surgical suture is a critical medical device used to close and secure body tissues following surgery, injury, or other procedures, but it often associated with the risk of site infections (SSIs). To mitigate this risk, drug‐eluting sutures antimicrobial anti‐inflammatory properties have been developed. However, incorporation active pharmaceutical ingredients (APIs) frequently compromises mechanical sutures. address these challenges, curcumin‐loaded microspheres were first produced via emulsion solvent evaporation method then embedded into polymeric carriers PCL‐PEG using melt‐extrusion technique achieve optimal diameters, thereby enhancing strength creating an innovative drug‐delivery system. Notably, containing Cur‐PLA‐PEG‐PCL demonstrated highest tensile (170.20 ± 22.73 MPa) due presence PCL. Meanwhile, Cur‐PLA‐PEG exhibited high breaking stability during degradation, retaining 89.96% their initial by Day 14. All samples also antibacterial activity, direct correlation between incubation duration antioxidant potential. These findings suggest that hold significant potential for clinical applications in improving wound healing reducing infections. Highlights Curcumin‐loaded polymer melt extrusion. PLA‐PEG‐PCL offer 170.20 MPa. Sutures retain 14, showing degradation. Sustained release curcumin from provides prolonged therapeutic effects. inflammation, IL‐6 expression keratinocytes.

Язык: Английский

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