The Role of Inhaled Chitosan-Based Nanoparticles in Lung Cancer Therapy

Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 969 - 969

Опубликована: Июль 23, 2024

Lung cancer is the leading cause of cancer-related mortality worldwide, largely due to limited efficacy anticancer drugs, which primarily attributed insufficient doses reaching lungs. Additionally, patients undergoing treatment experience severe systemic adverse effects distribution drugs non-targeted sites. In light these challenges, there has been a growing interest in pulmonary administration for lung cancer. This route allows be delivered directly lungs, resulting high local concentrations that can enhance antitumor while mitigating toxic effects. However, poses challenge overcoming mechanical, chemical, and immunological defenses respiratory tract prevent inhaled drug from properly penetrating To overcome drawbacks, use nanoparticles inhaler formulations may promising strategy. Nanoparticles assist minimizing clearance, increasing penetration into epithelium, enhancing cellular uptake. They also facilitate increased stability, promote controlled release, delivery target sites, such as tumor environment. Among them, chitosan-based demonstrate advantages over other polymeric nanocarriers their unique biological properties, including activity mucoadhesive capacity. These properties have potential when administered via route. view above, this paper provides an overview research conducted on drug-loaded incorporated devices Furthermore, article addresses emerging technologies, siRNA (small interfering RNA), context therapy. Particularly, recent studies employing are described.

Язык: Английский

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Nanotherapeutics in malaria

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 495 - 522

Опубликована: Янв. 1, 2025

Язык: Английский

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Chitosan nanoparticle-mediated approaches for wound healing

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 207 - 226

Опубликована: Янв. 1, 2025

Язык: Английский

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Advances in Materials Science for Precision Melanoma Therapy: Nanotechnology-Enhanced Drug Delivery Systems

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 296 - 296

Опубликована: Фев. 24, 2025

Melanoma, a highly aggressive form of skin cancer, poses major therapeutic challenge due to its metastatic potential, resistance conventional therapies, and the complexity tumor microenvironment (TME). Materials science nanotechnology advances have led using nanocarriers such as liposomes, dendrimers, polymeric nanoparticles, metallic nanoparticles transformative solutions for precision melanoma therapy. This review summarizes findings from Web Science, PubMed, EMBASE, Scopus, Google Scholar highlights role in overcoming treatment barriers. Nanoparticles facilitate passive active targeting through mechanisms enhanced permeability retention (EPR) effect functionalization with tumor-specific ligands, thereby improving accuracy drug delivery reducing systemic toxicity. Stimuli-responsive systems multi-stage further improve overcome challenges poor penetration resistance. Emerging platforms combine diagnostic imaging delivery, paving way personalized medicine. However, there are still issues scalability, biocompatibility, regulatory compliance. comprehensive potential integrating genetics proteomics, scalable, patient-specific therapies. These interdisciplinary innovations promise redefine provide safer, more effective, accessible treatments. Continued research is essential bridge gap between evidence-based scientific clinical applications.

Язык: Английский

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Folic acid functionalization of rGO/Co3O4/Chitosan based biocompatible nanocomposite enhances targeted delivery and cytotoxicity of Doxorubicin

Composites Communications, Год журнала: 2025, Номер unknown, С. 102362 - 102362

Опубликована: Март 1, 2025

Язык: Английский

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