Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2023, Номер 683, С. 133002 - 133002
Опубликована: Дек. 15, 2023
Язык: Английский
Brazilian Journal of Biology, Год журнала: 2023, Номер 83
Опубликована: Янв. 1, 2023
Abstract A significant public health issue worldwide is metabolic syndrome, a cluster of illnesses that comprises insulin resistance, obesity, dyslipidemia, hyperglycemia, and hypertension. The creation natural treatments preventions for syndrome crucial. Chitosan, along with its nanoformulations, an oligomer chitin, the second-most prevalent polymer in nature, which created via deacetylation. Due to plentiful biological actions recent years, chitosan nanoformulations have drawn much interest. Recently, nanoparticle-based delivery CRISPR-Cas9 has been applied treating syndromes. benefits on diabetes mellitus, hypertension will be outlined present review, highlighting potential mechanisms avoidance medication syndromes by nanoformulations.
Язык: Английский
Процитировано
5
Nanomedicine, Год журнала: 2024, Номер 19(14), С. 1253 - 1269
Опубликована: Май 8, 2024
Cancer is one of the leading causes mortality worldwide, and its treatment faces several challenges. Phytoconstituents derived from recently discovered medicinal plants through nanotechnology potentially target cancer cells via PI3K/Akt/mTOR pathways exert their effects selectively generation reactive oxygen species β-catenin inhibition, DNA damage, increasing caspase 3/9 p53 expression. These nanocarriers act specifically against different cell lines such as HT-29, MOLT-4 human leukemia MCF-7 SKOV-3, Caov-3, SW-626, HepG2, A-549, HeLa, MCF-7. This review comprehensively elaborates on cellular molecular mechanisms, therapeutic prospects various plant-mediated nanoformulations to attain a revolutionary shift in immunotherapy.
Язык: Английский
Процитировано
1
Journal of Food Measurement & Characterization, Год журнала: 2024, Номер 18(7), С. 5254 - 5264
Опубликована: Июнь 7, 2024
Язык: Английский
Процитировано
1
Nano Trends, Год журнала: 2024, Номер 7, С. 100040 - 100040
Опубликована: Июнь 12, 2024
Quercetin (QUE), tannic acid (TA) and ascorbic (AA) are among the antioxidants that have demonstrated efficacy in treatment prevention of cancer, cardiovascular neurodegenerative diseases. However, optimal method administering these compounds for therapeutic purposes is not well understood, especially when considering their differences size solubility. In this context, nanoencapsulation rises as a promising strategy, since technology could protect active ingredients maximize absorption. study, aforementioned were encapsulated lipid mixture with objective developing nontoxic effective materials antitumor therapy. The results satisfactorily Large Unilamellar Vesicles (LUVs) composed phosphatidylcholine (PC) phosphatidylglycerol (PG). formulations exhibited good homogeneity average stability, investigated by dynamic light scattering zeta potential measurements. encapsulation efficiency was follows: QUE (78.76%) > TA (61.93%) AA (47.13%). Korsmeyer-Peppas model employed to analyze release kinetics, illustrating delivery follows Fick's law. Biological tests using bioactive-loaded LUVs resulted low-toxicity formulations. Quercetin-loaded (QUE-LUVs) stood out studied, tumor cell viability significantly reduced after QUE-LUVs compared untreated cells. Furthermore, differential cytotoxic effect between cells non-tumor cells, suggesting applications anticancer Aligned demand innovative treatments drug methods show less toxicity adverse effects, approach developed present study significant versatility, serve mixed lipid-based system management antioxidant
Язык: Английский
Процитировано
1
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2023, Номер 683, С. 133002 - 133002
Опубликована: Дек. 15, 2023
Язык: Английский
Процитировано
2