Pharmaceutics,
Год журнала:
2023,
Номер
15(11), С. 2608 - 2608
Опубликована: Ноя. 9, 2023
Owing
to
its
antibacterial,
anti-inflammatory,
and
antioxidant
activities,
in
the
last
few
years,
lavender
essential
oil
(LVO)
has
been
used
medical
applications
as
a
promising
approach
for
treating
infected
wounds.
However,
practical
applicability
of
LVO
is
limited
by
high
volatility
storage
stability.
This
study
aimed
develop
novel
hybrid
hydrogel
combining
phytic
acid
(PA)-crosslinked
sodium
alginate
(SA)
poly(itaconic
anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]
undecane
(PITAU)
evaluate
potential
effectiveness
an
antibacterial
wound
dressing
after
incorporating
LVO.
The
influence
mass
ratio
between
SA
PITAU
on
properties
stability
hydrogels
was
investigated.
After
loading,
effect
addition
their
functional
associated
structural
changes
studied.
FTIR
analysis
revealed
that
hydrogen
bonding
primary
interaction
mechanism
components
hydrogels.
morphology
analyzed
using
SEM,
evidencing
porosity
dependent
PITAU,
while
droplets
were
well
dispersed
polymer
blend.
release
from
determined
UV-VIS
spectroscopy,
indicating
sustained
over
time,
independent
concentration.
In
addition,
tested
antimicrobial
activity
against
Gram-positive
Gram-negative
bacteria.
Very
good
obtained
case
sample
SA_PITAU3+LVO10%
S.
aureus
C.
albicans.
Moreover,
vivo
tests
showed
increased
compared
oil-free
scaffold
may
aid
accelerating
healing
process
Pharmaceutics,
Год журнала:
2024,
Номер
16(3), С. 423 - 423
Опубликована: Март 19, 2024
One
of
the
major
challenges
in
harnessing
therapeutic
benefits
curcumin
(an
active
ingredient
from
turmeric)
is
its
poor
bioavailability
due
to
short
biological
half-life.
In
this
regard,
nanoformulations
have
shown
tremendous
hope
for
improving
pharmacokinetic
and
behavior
by
altering
stability
bioavailability.
Biopolymers,
especially
alginate
chitosan,
received
special
attention
as
excipients
prepare
their
abundant
availability,
biocompatibility,
amicability
form
different
types
self-assembled
structures
ease
undergoing
chemical
modifications.
However,
there
are
certain
challenges,
such
water
solubility
under
physiological
conditions
heterogeneity
with
regard
molecular
weight
large-scale
production
well-preserved
nanostructures.
Substantial
advancement
has
been
achieved
towards
overcoming
these
developing
newer
derivatives
through
a
modifications
approach,
ascertained
suitability
chitosan
drug
delivery
systems
(DDS).
The
present
minireview
briefly
discusses
limitation
molecule,
carbohydrates
DDS,
recent
developments
related
chitosan-based
curcumin.
Special
emphasis
given
highlighting
impact
efficacy
Separation and Purification Technology,
Год журнала:
2024,
Номер
352, С. 128160 - 128160
Опубликована: Май 31, 2024
The
focus
of
the
study
concerned
application
alginate
membranes
enriched
with
a
mixture
Magnequench
Fine
Powder
(MQFP)
and
Molecular
Magnet
[Fe4(acac)6(Br-mp)2]
(MM)
in
different
proportions
to
improve
ethanol
dehydration
via
pervaporation.
paper
concentrated
on
how
combined
fillers
affected
ability
transport
ethanol/water
solution
components.
It
was
observed
that
integration
MM
into
MQFP
not
only
improved
magnetic
properties
but
also
provided
uniform
distribution
filler
matrix.
By
merging
two
fillers,
we
achieved
outstanding
separation
process
performance.
This
efficiency
unattainable
using
each
separately,
highlighting
synergistic
effect
combining
fillers.
membrane
1wt%
9
wt%
proved
be
most
efficient,
highest
Pervaporation
Separation
Index
factor,
reaching
40974
kg⋅m−2⋅h−1
12735.14,
respectively.
Pharmaceutics,
Год журнала:
2023,
Номер
15(11), С. 2608 - 2608
Опубликована: Ноя. 9, 2023
Owing
to
its
antibacterial,
anti-inflammatory,
and
antioxidant
activities,
in
the
last
few
years,
lavender
essential
oil
(LVO)
has
been
used
medical
applications
as
a
promising
approach
for
treating
infected
wounds.
However,
practical
applicability
of
LVO
is
limited
by
high
volatility
storage
stability.
This
study
aimed
develop
novel
hybrid
hydrogel
combining
phytic
acid
(PA)-crosslinked
sodium
alginate
(SA)
poly(itaconic
anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]
undecane
(PITAU)
evaluate
potential
effectiveness
an
antibacterial
wound
dressing
after
incorporating
LVO.
The
influence
mass
ratio
between
SA
PITAU
on
properties
stability
hydrogels
was
investigated.
After
loading,
effect
addition
their
functional
associated
structural
changes
studied.
FTIR
analysis
revealed
that
hydrogen
bonding
primary
interaction
mechanism
components
hydrogels.
morphology
analyzed
using
SEM,
evidencing
porosity
dependent
PITAU,
while
droplets
were
well
dispersed
polymer
blend.
release
from
determined
UV-VIS
spectroscopy,
indicating
sustained
over
time,
independent
concentration.
In
addition,
tested
antimicrobial
activity
against
Gram-positive
Gram-negative
bacteria.
Very
good
obtained
case
sample
SA_PITAU3+LVO10%
S.
aureus
C.
albicans.
Moreover,
vivo
tests
showed
increased
compared
oil-free
scaffold
may
aid
accelerating
healing
process
