Potential of Chitosan/Gelatin-Based Nanofibers in Delivering Drugs for the Management of Varied Complications: A Review

Polymers, Год журнала: 2025, Номер 17(4), С. 435 - 435

Опубликована: Фев. 7, 2025

Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based systems, particularly nanoparticles (NPs) nanofibers (NFs), emerged promising solutions for biomedicine delivery. NFs, with their ability to mimic the porous fibrous structures of biological tissues, garnered significant interest in drug-delivering applications. Biopolymers gelatin (Ge) chitosan (CH) gained much more attention due biocompatibility, biodegradability, versatility biomedical CH exhibits exceptional anti-bacterial activity, wound healing capabilities, whereas Ge provides good biocompatibility cell adhesion properties. Ge/CH-based NFs stimulate cellular connections facilitate tissue regeneration owing structural resemblance extracellular matrix. This review explores additive preparation, including electrospinning, force pinning, template synthesis, focusing on electrospinning factors influencing fiber structure. The properties CH, role release, formulation strategies, characterization techniques electrospun fibers are discussed. Furthermore, this addresses applications delivering active moieties management orthopedics regulatory considerations, along challenges related them. Thus, aims provide a comprehensive overview potential

Язык: Английский

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A Novel Method to Enhance the Mechanical Properties of Polyacrylonitrile Nanofiber Mats: An Experimental and Numerical Investigation

Polymers, Год журнала: 2024, Номер 16(7), С. 992 - 992

Опубликована: Апрель 4, 2024

This study addresses the challenge of enhancing transverse mechanical properties oriented polyacrylonitrile (PAN) nanofibers, which are known for their excellent longitudinal tensile strength, without significantly compromising inherent porosity, is essential effective filtration. explores effects doping PAN nanofiber composites with varying concentrations polyvinyl alcohol (PVA) (0.5%, 1%, and 2%), introduced into matrix via a dip-coating method. approach ensured random distribution PVA within mat, aiming to leverage synergistic interactions between fibers improve composite’s overall performance. synergy primarily manifested in structural functional augmentation mats through localized agglomerations, thin films fibers, coatings on themselves. Comprehensive evaluation techniques were employed, including scanning electron microscopy (SEM) morphological insights; testing; thermogravimetric analysis (TGA) thermal stability; differential calorimetry (DSC) behavior analyses. Additionally, finite element method (FEM) was conducted numerical simulation composite. Using our novel method, results demonstrated that minimal concentration solution effectively preserved porosity while its strength. Moreover, simulations showed strong agreement experimental results, validating effectiveness sacrificing porosity.

Язык: Английский

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Design of Lattice-Based Energy-Absorbing Structure for Enhancing the Crashworthiness of Advanced Air Mobility

Aerospace, Год журнала: 2025, Номер 12(4), С. 332 - 332

Опубликована: Апрель 12, 2025

The development of advanced air mobility—an eco-friendly, next-generation transportation system—is underway and garners significant attention. Due to the novel propulsion concept eVTOL (electric Vertical Take-Off Landing) its operation in low altitude, urban environment, regulations for commercialization have not yet been established. Consequently, related research on passenger safety emergency landings is ongoing, this study focuses enhancing crashworthiness mobility. To ensure mobility, civil airworthiness standards were referenced determine appropriate test conditions, a design criterion developing an energy-absorbing structure was derived. In study, lattice structures are considered designing that satisfies criterion, finite element analysis conducted predict performance structures. Based predicted data, surrogate models constructed using Kriging method according type structure. verify data obtained from numerical models, representative manufactured EBM (Electron Beam Melting) technology, compressive tests obtain force–displacement curves. compared with it confirmed show good agreement data. After confirmation, utilized select lattice-based crashworthiness-related criterion. Finally, crash simulation vertical drop carried out selected structure, results indicate resulting acceleration due collision below human tolerance limit, thereby verifying

Язык: Английский

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Influence of Iron(III) Oxide Nanorods on the Mechanical and Thermal Properties of Pan Nanofiber Mats

Latvian Journal of Physics and Technical Sciences, Год журнала: 2025, Номер 62(1), С. 78 - 86

Опубликована: Янв. 27, 2025

Abstract This study delves into the integration of iron (III) oxide (Fe 2 O 3 ) nanorods orientated polyacrylonitrile (PAN) nanofiber mats, a topic considerable interest in applications such as water treatment and environmental remediation. Focussing on modification PAN nanofibers, research investigates impact varying concentrations (1 %, % 5 %) Fe mechanical thermal properties mats. Mechanical strength was evaluated by tensile testing, while stability thermogravimetric analysis (TGA). The results indicate notable improvement with an increase up to 24 observed at highest nanorod concentration %. However, mats showed decrease approximately 12 per TGA results. provides new insights effect reinforcement highlighting trade-offs between enhancement stability.

Язык: Английский

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Deformation Behaviour of Oriented Electrospun Pan Nanofiber Mats

Latvian Journal of Physics and Technical Sciences, Год журнала: 2025, Номер 62(2), С. 60 - 66

Опубликована: Март 26, 2025

Abstract The research addresses the limited understanding of deformation behaviour in mechanically loaded orientated electrospun nanofiber mats, which are crucial for applications such as filtration, catalysis, and sensing. Focussing on polyacrylonitrile (PAN) a reference polymer, we investigated mechanical properties PAN membranes with aligned fibre orientations, specifically examining their response to stresses introduced by notches punch holes. Mechanical testing revealed that these showed consistent pattern at macroscale until fracture. In particular, observed significant variations key parameters elastic modulus, ultimate strength, critical stress different membrane samples, were also compared an analytical model. presence notch mat reduced strength 48 %, indicating remarkable fracture resistance, even pre-damaged membranes. Furthermore, elongation fibres along loading direction was cause tip crack not grow, providing local reinforcement undamaged nanofibers enhancing its overall robustness.

Язык: Английский

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Modulating Cell Adhesion and Infiltration in Advanced Scaffold Designs based on PLLA Fibers with rGO and MXene (Ti3C2T )

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101785 - 101785

Опубликована: Апрель 1, 2025

The development of electrospun scaffolds that support cell adhesion and infiltration remains a critical challenge in tissue engineering. In this study, we investigate the influence two-dimensional (2D) fillers-reduced graphene oxide (rGO) MXene (Ti3C2T x )-incorporated into poly(L-lactic acid) (PLLA) fibers on their properties osteoblast responses. presence fillers modified fiber arrangement created varying inter-fiber spacing due to surface charge repulsion agglomeration. Importantly, potential measurements via Kelvin probe force microscopy (KPFM) PLLA show significant shift caused by incorporation Ti3C2T ∼400 mV compared ∼50 for rGO. vitro tests indicate rGO-modified up ∼100 μm, unlike fibers, which limit maximum ∼70 μm. However, promotes even deeper (∼120 μm) more uniform cell's changes scaffold architecture. High-resolution confocal imaging confirmed PLLA-Ti3C2T fosters larger, elongated site clusters cells, whereas rGO increases density relation without any filler. Our findings highlight distinct roles modulating geometry, mechanical behavior, cellular interactions. Tailoring composition distribution conductive offers promising strategy optimizing performance engineering applications.

Язык: Английский

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Development and Characterisation of Biaxial Pan Nanofiber Mats

Latvian Journal of Physics and Technical Sciences, Год журнала: 2025, Номер 62(3), С. 14 - 21

Опубликована: Май 27, 2025

Abstract This study addresses the challenge of enhancing strength polyacrylonitrile (PAN) nanofiber mats in transverse direction, which is a critical aspect for filtration applications targeting micro-sized viruses and bacteria. Traditional methods producing orientated nano-fibers often result with limited strength. To overcome this, our research focused on developing biaxial nanofibers, exhibit enhanced interbonding both axial directions. Using single-syringe electrospinning setup rotating drum collector, we successfully fabricated biaxially PAN mats. Scanning electron microscopy (SEM) analysis was employed to visualise confirm arrangement porous structure Mechanical testing further demonstrated that these arranged nanofibers possessed comparable orientations, signifying significant advancement structural integrity applications.

Язык: Английский

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Integrating an antimicrobial nanocomposite to bioactive electrospun fibers for improved wound dressing materials

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 24, 2024

This study investigates the fabrication and characterization of electrospun poly (ε-caprolactone)/poly (vinyl pyrrolidone) (PCL/PVP) fibers integrated with a nanocomposite chitosan, silver nanocrystals, graphene oxide (ChAgG), aimed at developing advanced wound dressing materials. The ChAgG nanocomposite, recognized for its antimicrobial biocompatible properties, was incorporated into PCL/PVP through electrospinning techniques. We assessed resultant fibers' morphological, physicochemical, mechanical which exhibited significant enhancements in strength demonstrated effective activity against common bacterial pathogens. findings suggest that PCL/PVP-ChAgG maintain biocompatibility facilitate controlled therapeutic delivery, positioning them as promising solution managing chronic burn-related wounds. underscores potential these materials to improve healing outcomes cost-effectively, particularly settings plagued by high incidences burn injuries. Further clinical investigations are recommended explore innovative full real-world applicability.

Язык: Английский

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Comparative Analysis of Thermal Characteristics: Virgin Polyacrylonitrile (PAN) Versus Electrospun Pan Nanofibre Mats

Latvian Journal of Physics and Technical Sciences, Год журнала: 2024, Номер 61(4), С. 98 - 105

Опубликована: Июль 18, 2024

Abstract The utility of polymers in the fabrication nanofibres via electrospinning is well established. Paramount to their application understanding thermal properties, as these dictate not only processability but also mechanical robustness, stability under elevated temperatures, and suitability for intended applications. process, which involves heating subjecting them high voltage, inherently modifies characteristics. This study attempts elucidate alterations, particularly by focusing on polyacrylonitrile (PAN) nanofibres. Employing techniques such thermogravimetric analysis (TGA) Differential Scanning Calorimetry (DSC), compares properties electrospun PAN nanofibre mats with those virgin counterparts. were synthesised polymer solution collecting resultant mat a flat plate collector. For comparative analysis, PAN, from derived, underwent identical testing. findings reveal reduction glass transition temperature approximately 3–5 % compared PAN. In addition, significant heat capacity about 42 was observed Additionally, TGA results indicated solvent evaporation at 110 °C. Therefore, this investigation sheds light nuanced alterations characteristics result providing vital insights various management scenarios.

Язык: Английский

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STATE OF THE ART AND LITERATURE REVIEW RESEARCH OF HOLLOW NANOFIBERS: FOCUSING ON FABRICATION, CAD IMPLEMENTATION AND OPTIMISATION

Environment Technology Resources Proceedings of the International Scientific and Practical Conference, Год журнала: 2024, Номер 3, С. 114 - 122

Опубликована: Июнь 22, 2024

The introduction of nanotechnology has resulted in a new era materials research, with hollow nanofibers emerging as key innovation. These nanofibers, distinguished by their nano size diameters and structures, have generated significant interest due to potential applications variety industries. However, despite advantageous properties, manufacture analysis these face challenges, particularly terms mechanical stability structural integrity when subjected external stresses. Identifying addressing vulnerabilities is crucial for the advancement various industrial biomedical fields. production notably via electrospinning technique, been topic great deal research. One bases this research utilization computer-aided (CAD) simulations, which include techniques such Representative Volume Element (RVE) analysis, Finite Method (FEM), multiscale numerical simulation, optimization strategies. sophisticated tools offer magnified view into nano-structural behaviour enabling precise predictions about properties behaviours under diverse conditions. This approach revolutionary, it allows exploration theoretical practical aspects material without constraints traditional experimental methodologies. article in-depth scientific review on aspects.

Язык: Английский

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