Gels,
Год журнала:
2025,
Номер
11(2), С. 131 - 131
Опубликована: Фев. 12, 2025
Local
anesthetics
(LAs)
have
been
indispensable
in
clinical
pain
management,
yet
their
limitations,
such
as
short
duration
of
action
and
systemic
toxicity,
necessitate
improved
delivery
strategies.
Hydrogels,
with
biocompatibility,
tunable
properties,
ability
to
modulate
drug
release,
extensively
explored
platforms
for
enhancing
LA
efficacy
safety.
This
narrative
review
explores
the
historical
development
LAs,
physicochemical
applications,
providing
a
foundation
understanding
integration
hydrogels
anesthetic
delivery.
Advances
thermoresponsive,
stimuli-responsive,
multifunctional
demonstrated
significant
potential
prolonging
analgesia
reducing
exposure
preclinical
studies,
while
early
findings
highlight
feasibility
thermoresponsive
hydrogel
formulations.
Despite
these
advancements,
challenges
burst
mechanical
instability,
regulatory
considerations
remain
critical
barriers
translation.
Emerging
innovations,
including
nanocomposite
hydrogels,
biofunctionalized
matrices,
smart
materials,
offer
solutions
limitations.
Future
research
should
focus
on
optimizing
formulations,
expanding
validation,
integrating
advanced
fabrication
technologies
3D
printing
artificial
intelligence-driven
design
enhance
personalized
management.
By
bridging
materials
science
pharmacology,
this
provides
comprehensive
perspective
current
trends
future
directions
hydrogel-based
systems.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 24, 2025
The
liver
performs
crucial
roles
in
energy
metabolism,
detoxification,
and
immune
regulation.
Hepatic
diseases,
including
hepatitis,
fibrosis,
cancer,
have
posed
a
significant
threat
to
global
health,
emphasizing
the
critical
need
for
development
of
novel
effective
treatment
approaches.
Nanotechnology,
an
emerging
technology,
has
been
extensively
researched
medicine.
Among
many
types
nanomaterials,
polymeric
nanoparticles
(NPs)
are
widely
used
drug
delivery
systems.
Compared
traditional
therapies,
they
offer
advantages
disease
by
improving
outcomes
reducing
side
effects.
This
review
introduced
discussed
application
natural
polymers
synthetic
their
management.
Furthermore,
this
paper
reviewed
-mainly
chitosan
(CS),
hyaluronic
acid
(HA),
polyethylene
glycol
(PEG)
poly
(lactic-co-glycolic
acid)
(PLGA)-in
treatment,
focusing
on
use
various
systems
pure
bioactive
compounds
origin,
drugs,
nucleic
acids,
peptides,
others.
Finally,
challenges
future
perspectives
NPs
were
provide
guidance
further
research
directions,
with
aim
promoting
clinical
nanotherapeutics
treating
hepatic
diseases.
Polymers,
Год журнала:
2024,
Номер
16(13), С. 1878 - 1878
Опубликована: Июль 1, 2024
Heart
problems
are
quite
prevalent
worldwide.
Cardiomyocytes
and
stem
cells
two
examples
of
the
supporting
matrix
that
used
in
integrated
process
cardiac
tissue
regeneration.
The
objective
is
to
create
innovative
materials
can
effectively
replace
or
repair
damaged
muscle.
One
most
effective
appealing
3D/4D
scaffolds
for
creating
an
appropriate
milieu
growth
healing
hydrogel.
In
order
successfully
regenerate
heart
tissue,
bioactive
biocompatible
hydrogels
required
preserve
infarcted
region
bid
support
restoration
myocardial
wall
stress,
cell
survival
function.
engineering
uses
a
variety
hydrogels,
such
as
natural
synthetic
polymeric
hydrogels.
This
article
provides
quick
overview
various
hydrogel
types
employed
engineering.
Their
benefits
drawbacks
discussed.
Hydrogel-based
techniques
regeneration
also
addressed,
along
with
their
clinical
application
future
Biomacromolecules,
Год журнала:
2024,
Номер
25(11), С. 7015 - 7057
Опубликована: Окт. 18, 2024
Biomedical
polymers
play
a
key
role
in
preventing,
diagnosing,
and
treating
diseases,
showcasing
wide
range
of
applications.
Their
unique
advantages,
such
as
rich
source,
good
biocompatibility,
excellent
modifiability,
make
them
ideal
biomaterials
for
drug
delivery,
biomedical
imaging,
tissue
engineering.
However,
conventional
suffer
from
poor
degradation
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 20, 2024
The
extensive
utilization
of
natural
polymers
in
tissue
engineering
is
attributed
to
their
excellent
biocompatibility,
degradability,
and
resemblance
the
extracellular
matrix.
These
have
a
wide
range
applications
such
as
delivering
therapeutic
medicine,
detecting
diseases,
sensing
biological
substances,
promoting
regeneration,
treating
diseases.
This
brief
review
current
developments
properties
uses
widely
used
biomedical
derived
from
nature.
Additionally,
it
explores
correlation
between
characteristics
functions
these
materials
different
highlights
prospective
direction
for
advancement
polymer
engineering.
Polymers,
Год журнала:
2024,
Номер
16(23), С. 3240 - 3240
Опубликована: Ноя. 22, 2024
Polymeric
membranes
have
emerged
as
a
versatile
and
efficient
liquid
separation
technology,
addressing
the
growing
demand
for
sustainable,
high-performance
processes
in
various
industrial
sectors.
This
review
offers
an
in-depth
analysis
of
recent
developments
polymeric
membrane
focusing
on
materials'
advancements,
innovative
fabrication
methods,
strategies
improving
performance.
We
discuss
underlying
principles
separation,
selecting
suitable
polymers,
integrating
novel
materials,
such
mixed-matrix
composite
membranes,
to
enhance
selectivity,
permeability,
antifouling
properties.
The
article
also
highlights
challenges
limitations
associated
with
including
stability,
fouling,
scalability,
explores
potential
solutions
overcome
these
obstacles.
aims
guide
development
next-generation
sustainable
by
offering
detailed
current
research
future
directions.
ACS Pharmacology & Translational Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Skin
cancer
represents
a
major
health
concern
due
to
its
rising
incidence
and
limited
treatment
options.
Current
treatments
(surgery,
chemotherapy,
radiotherapy,
immunotherapy,
targeted
therapy)
often
entail
high
costs,
patient
inconvenience,
significant
adverse
effects,
therapeutic
efficacy.
The
search
for
novel
options
is
also
marked
by
the
capital
investment
extensive
development
involved
in
drug
discovery
process.
In
response
these
challenges,
repurposing
existing
drugs
topical
application
optimizing
their
delivery
through
nanotechnology
could
be
answer.
This
innovative
strategy
aims
combine
advantages
of
known
pharmacological
background
commonly
used
expedite
development,
with
nanosystem-based
formulations,
which
among
other
allow
improved
skin
permeation
retention
overall
higher
efficacy
safety.
present
review
provides
critical
analysis
repurposed
such
as
doxycycline,
itraconazole,
niclosamide,
simvastatin,
leflunomide,
metformin,
celecoxib,
formulated
into
different
nanosystems,
namely,
nanoemulsions
nanoemulgels,
nanodispersions,
solid
lipid
nanoparticles,
nanostructured
carriers,
polymeric
hybrid
lipid-polymer
electrospun
nanofibrous
scaffolds,
liposomes
liposomal
gels,
ethosomes
ethosomal
aspasomes,
outcomes
battle
against
cancer.
Enhanced
antitumor
effects
on
melanoma
nonmelanoma
research
models
are
highlighted,
some
nanoparticles
even
showing
intrinsic
anticancer
properties,
leading
synergistic
effects.
explored
findings
highly
evidence
potential
approaches
complement
currently
available
strategies
hope
that
might
one
day
reach
pharmaceutical
market.
