Recent Emerging Trends in Dendrimer Research: Electrochemical Sensors and Their Multifaceted Applications in Biomedical Fields or Healthcare
Biosensors and Bioelectronics,
Год журнала:
2025,
Номер
273, С. 117172 - 117172
Опубликована: Янв. 15, 2025
Язык: Английский
Magnetic Nanoparticles and Drug Delivery Systems for Anti-Cancer Applications: A Review
Nanomaterials,
Год журнала:
2025,
Номер
15(4), С. 285 - 285
Опубликована: Фев. 13, 2025
Cancer
continues
to
be
a
prominent
fatal
health
issue
worldwide,
driving
the
urgent
need
for
more
effective
treatment
strategies.
The
pressing
demand
has
sparked
significant
interest
in
development
of
advanced
drug
delivery
systems
chemotherapeutics.
advent
nanotechnology
offers
groundbreaking
approach,
presenting
promising
pathway
revolutionize
cancer
and
improve
patient
outcomes.
Nanomedicine-based
have
demonstrated
capability
improving
pharmacokinetic
properties
accumulation
chemotherapeutic
agents
sites
while
minimizing
adverse
side
effects.
Despite
these
advantages,
most
NDDSs
exhibit
only
limited
improvement
during
clinical
trials.
recent
magnetic
nanoparticles
(MNPs)
biomedical
applications
revealed
potential
opportunity
further
enhance
performance
NDDSs.
MNPs
can
utilized
increase
targeting
capabilities
NDDSs,
controlled
release
agents,
weaken
chemoresistance
tumors
with
hyperthermia.
In
this
review,
we
will
explore
advancements
research
oncology
applications,
how
their
augment
when
complexed
them
emphasize
challenges
safety
concerns
incorporating
into
treatment.
Язык: Английский
Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities
Cancers,
Год журнала:
2025,
Номер
17(4), С. 701 - 701
Опубликована: Фев. 19, 2025
Glioblastoma
multiforme
(GBM)
is
a
highly
malignant
brain
tumor
that
has
bleak
outlook
despite
existing
treatments
such
as
surgery,
radiation,
and
chemotherapy.
The
utilization
of
nanoparticles
for
drug
delivery
presents
promising
method
by
which
to
improve
the
effectiveness
treatment
while
reducing
harmful
effects
on
entire
body.
This
review
examines
application
in
GBM,
focusing
different
types
nanoparticles,
including
lipid-based,
polymeric,
metallic,
those
under
development.
Every
variety
analyzed
its
distinct
characteristics
therapeutic
capacity.
Lipid-based
liposomes
solid
lipid
enhance
transport
medicines
are
not
soluble
water
have
shown
considerable
potential
preclinical
investigations.
Polymeric
benefits
terms
controlled
release
targeted
distribution,
whereas
metallic
both
therapy
imaging.
In
current
we
would
like
emphasize
ways
medicine
delivery,
specifically
enhancing
penetration
blood-brain
barrier
(BBB),
targeting
tumors,
enabling
release.
Additionally,
also
discuss
clinical
discoveries,
highlighting
achievements
obstacles
process
converting
these
technologies
into
effective
GBM.
study
offers
thorough
examination
present
status
prospects
Язык: Английский
Human Embryonic Kidney HEK293 Cells as a Model to Study SMVT-Independent Transport of Biotin and Biotin-Furnished Nanoparticles in Targeted Therapy
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1594 - 1594
Опубликована: Фев. 13, 2025
The
aim
of
this
study
was
to
investigate
the
usefulness
human
embryonic
kidney
HEK293
cells
as
a
model
normal
in
biotin-mediated
therapy.
expression
and
role
sodium
multivitamin
transporter
(SMVT)
uptake
accumulation
free
biotin,
well
cationic
neutral
biotinylated
PAMAM
dendrimers
fourth
generation
synthesized
our
laboratory,
were
assessed
comparison
other
immortalized
(HaCaT)
cancer
(HepG2,
U-118
MG).
obtained
data
showed
that
higher
level
SMVT
not
associated
with
stronger
biotin
dendrimers.
Biotinylation
increased
selective
an
inversely
proportional
manner
concentration
used;
however,
lower
than
cell
lines.
time-dependent
profiles
differed
significantly.
Therefore,
it
should
be
assumed
efficiency
nanoparticles'
depends
on
multiple
cellular
transport
mechanisms.
Toxicity
tests
significantly
sensitivity
conjugates
for
HepG2
HaCaT
cells.
Molecular
modeling
studies
profile
suggest
only
but
also
monocarboxylate
1
(MCT-1)
may
play
important
nanoparticles
into
Due
complexity
problem,
further
are
necessary.
In
summary,
can
considered
valuable
biotin-
targeted
therapy
using
based
Язык: Английский
Engineering PAMAM Dendrimers for Optimized Drug Delivery
Amin Aleebrahim Dehkordi,
Shirin Mollazadeh,
A. Talaie
и другие.
Nano Trends,
Год журнала:
2025,
Номер
unknown, С. 100094 - 100094
Опубликована: Фев. 1, 2025
Synthesis and application of poly(amidoamine) functional biomedical materials in the field of biomedicine over the past decade
Journal of the Chinese Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 28, 2024
Abstract
Over
the
past
decade,
significant
advancements
have
been
achieved
in
field
of
biomedicine,
particularly
treatment
critical
illness.
However,
there
remain
numerous
challenges
and
barriers
persist
drug
delivery,
medical
imaging,
diagnosis,
treatment.
Poly(amidoamine)
(PAMAM)
dendrimers
emerged
as
promising
candidates
for
development
functional
biomedical
materials
due
to
their
advantageous
properties,
including
ease
preparation,
controllable
size,
abundant
cavities,
water
solubility,
modifiability,
biocompatibility.
This
article
presents
a
comprehensive
review
synthesis,
application,
potential
toxicity
PAMAM
materials,
exploring
role,
significance,
applications
detail.
The
aim
is
provide
valuable
reference
future
inspire
further
discoveries
polyamide
materials.
Язык: Английский