Regenerative Engineering and Translational Medicine, Год журнала: 2025, Номер unknown
Опубликована: Май 6, 2025
Язык: Английский
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Янв. 22, 2025
Parkinson’s disease is a progressive neurodegenerative that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, surgical methods. However, these treatments often result in fluctuating symptoms, side effects, progression. Here, the authors have reviewed emerging field of nanomedicine as promising path for treatment, emphasizing its potential to overcome limitations traditional therapies. Nanomedicine utilizes nanoparticles targeted drug delivery, leveraging their small size high surface area volume ratio cross blood-brain barrier deliver therapeutic agents directly affected brain regions. Various nanoparticles, including lipid-based, polymeric, metallic, carbon-based, shown treatment. Additionally, nanocarrier systems like liposomes, nanogels, dendrimers, solid lipid offer controlled sustained release agents, enhancing bioavailability reducing effects. This review provides insights into pathophysiology disease, highlighting mechanisms neurodegeneration, role alpha-synuclein, disruption pathways. It further discusses application gene therapy conjunction with interventions.
Язык: Английский
Процитировано
5
Advanced Composites and Hybrid Materials, Год журнала: 2025, Номер 8(1)
Опубликована: Янв. 11, 2025
Chronic diseases such as cancer and diabetes demand advanced drug delivery methods that can accommodate precise, sustained, targeted release of active compounds. Existing carriers conventional capsules are limited by issues like poor bioavailability, mechanical fragility, unpredictable patterns. With the global market expected to surpass USD 1.8 trillion 2028, it is crucial address these challenges. Additionally, there a growing need develop biocompatible systems mitigate concerns about toxicity, environmental impact, patient compliance. Here, we review latest advancements in composite capsules, focusing on key aspects controlled release, properties, biocompatibility, antimicrobial potential. Composite materials offer customised mechanisms combining synthetic natural polymers. This has led improvements stability, encapsulation efficiency, bioavailability. Some noteworthy this field include development magnetic-responsive for therapies, alginate-based dual-release systems, solid lipid nanoparticles (SLNs) gene delivery. For example, lycopene whey protein composites achieved an impressive efficiency 94%, showcasing enhanced performance. have been developments pH-sensitive designed treatment, which drugs selectively tumour environments. Furthermore, multifunctional magnetic created facilitate MRI imaging remote-controlled release. Moreover, proven effective improving therapeutic outcomes treatments ensuring specifically within acidic microenvironment. Other notable achievements integration antioxidant nanoparticles, cerium oxide (CeO₂), into showing potential mitigating oxidative stress providing neuroprotection inflammatory neurodegenerative conditions. Despite innovations, persistent challenges related scalability, regulatory clearance, enduring biocompatibility necessitate further investigation. These combined possess significant potential, presenting more intelligent, adaptable positioned transform personalised medicine future healthcare solutions.
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141394 - 141394
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 6, 2025
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, necessitating innovative therapeutic approaches. Polymer-based nanotechnology has emerged as a promising solution, offering precise drug delivery, enhanced blood-brain barrier (BBB) penetration, adaptability to tumor microenvironment (TME). This review explores diverse applications polymeric nanoparticles (NPs) in GBM treatment, including delivery chemotherapeutics, targeted therapeutics, immunotherapeutics, other agents for radiosensitization photodynamic therapy. Recent advances multifunctional polymer highlight their potential overcome challenges that brought, such heterogeneity tumor, BBB limitation, immunosuppressive TME, consideration biocompatibility safety. Meanwhile, future directions address these are also proposed. By addressing obstacles, polymer-based represents transformative strategy improving treatment outcomes, paving way more effective patient-specific therapies.
Язык: Английский
Процитировано
2
Heliyon, Год журнала: 2024, Номер 11(1), С. e41465 - e41465
Опубликована: Дек. 24, 2024
Язык: Английский
Процитировано
7
Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 104880 - 104880
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Tissue Engineering and Regenerative Medicine, Год журнала: 2025, Номер unknown
Опубликована: Март 12, 2025
Язык: Английский
Процитировано
1
Drug Development and Industrial Pharmacy, Год журнала: 2025, Номер unknown, С. 1 - 31
Опубликована: Март 21, 2025
This review examines recent advancements in nanoparticle-based delivery systems for phytochemicals, focusing on their role overcoming multidrug resistance, improving therapeutic efficacy, and facilitating clinical translation. highlights advances nanoparticle-enabled phytochemical to enhance bioavailability, improve outcomes, enable targeted applications. By comparing various nanoparticle systems, formulation methods, efficacy data, it identifies gaps current research guides the development of more effective, next-generation phytochemical-loaded nanocarriers. A systematic literature published between 2000 2024 was conducted using PubMed, Scopus, Web Science. Articles cancer therapy were included. Compounds such as curcumin, resveratrol, quercetin, epigallocatechin gallate demonstrate enhanced anti-cancer when encapsulated nanoparticles, leading improved increased tumor cell targeting, reduced toxicity. Clinical trials indicate regression fewer adverse effects. Emerging approaches-such nanogels, hybrid combination therapies with immune checkpoint inhibitors-further refine treatment efficacy. Nanoparticle-based significantly potential making them promising candidates safer, effective treatments. However, challenges related regulatory guidelines, scalability, long-term safety must be addressed fully realize potential.
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 13, 2024
Drug resistance poses a significant challenge in the treatment of breast cancer. In recent years, variety nanomaterials have been discovered and synthesized that can selectively target tumor cells play crucial role advancement cancer therapies. As our understanding heterogeneity deepens, emerging potential addressing drug has garnered considerable attention. These materials not only but also possess unique properties make them promising options for treatment, including low toxicity, excellent biocompatibility, ease preparation, ability to carry antitumor drugs, customizable surface functions. this review, we will comprehensively summarize two key developments treatment: application drugs nanomaterials. We explore mechanisms by which improve cancer, targeted nanotherapy strategies mitigate resistance, research advancements anticancer This overview aims highlight provide theoretical framework identifying optimal future.
Язык: Английский
Процитировано
3
Pharmaceutics, Год журнала: 2024, Номер 16(12), С. 1611 - 1611
Опубликована: Дек. 19, 2024
The blood–brain barrier (BBB) serves as a highly selective between the blood and central nervous system (CNS), its main function is to protect brain from foreign substances. This physiological property plays crucial role in maintaining CNS homeostasis, but at same time greatly limits delivery of drug molecules CNS, thus posing major challenge for treatment neurological diseases. Given that high incidence low cure rate diseases have become global public health problem, development effective BBB penetration technologies important enhancing efficiency delivery, reducing systemic toxicity, improving therapeutic outcomes review describes pathological properties BBB, well current challenges trans-BBB detailing structural basis protection. Secondly, this paper reviews strategies recent years, including physical, biological chemical approaches, nanoparticle-based technologies, provides comprehensive assessment effectiveness, advantages limitations these strategies. It hoped will provide valuable references inspiration future researchers studies
Язык: Английский
Процитировано
3