Innovative Polymeric Biomaterials for Intraocular Lenses in Cataract Surgery DOI Creative Commons
Kevin Y. Wu,

Rebecca Khammar,

Hormoz Sheikh

и другие.

Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(12), С. 391 - 391

Опубликована: Дек. 23, 2024

Intraocular lenses (IOLs) play a pivotal role in restoring vision following cataract surgery. The evolution of polymeric biomaterials has been central to addressing challenges such as biocompatibility, optical clarity, mechanical stability, and resistance opacification. This review explores essential requirements for IOL biomaterials, emphasizing their ability mitigate complications like posterior capsule opacification (PCO) dysphotopsias while maintaining long-term durability visual quality. Traditional materials, including polymethyl methacrylate (PMMA), silicone, acrylic polymers, are critically analyzed alongside cutting-edge innovations hydrogels, shape memory light-adjustable (LALs). Advances polymer engineering have enabled these materials achieve enhanced flexibility, transparency, driving adoption modern design. Functionalization strategies, surface modifications drug-eluting designs, highlight advancements preventing inflammation, infection, other complications. incorporation UV-blocking blue-light-filtering agents is also examined potential reducing retinal damage. Furthermore, emerging technologies nanotechnology smart polymer-based offer promising avenues personalized, biocompatible IOLs with performance. Clinical outcomes, acuity, contrast sensitivity, patient satisfaction, evaluated provide an understanding the current limitations development. We discuss future directions, underscoring need cost-effective, innovative solutions optimize surgical outcomes improve patients’ quality life.

Язык: Английский

Injectable and pH-Responsive Metformin-Loaded Hydrogel for Active Inhibition of Posterior Capsular Opacification DOI
Chao Yin, Yue Zhang, Cong Fan

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(44), С. 59880 - 59894

Опубликована: Окт. 22, 2024

Posterior capsular opacification (PCO) is a common complication following cataract surgery, which can lead to significant vision loss. This study introduces facile method for developing metformin-derived hydrogel (HCM6) stabilized by dynamic covalent bonds among natural polymers. demonstrates antifibrotic properties, on-demand drug release, pH responsiveness, injectability, and self-healing capabilities. Our in vitro experiments confirmed that the HCM6 exhibits excellent biocompatibility, inhibiting lens epithelial cell migration, transforming growth factor-2β (TGFβ2)-induced α-smooth muscle actin (α-SMA) expression cells. In vivo studies conducted rat extracapsular extraction (ECLE) model revealed significantly suppressed PCO after 21 days of implantation with no observed pathological effects on surrounding tissues or optic nerve. According our experimental results, inhibitory mechanism may be attributed metformin's suppressive effect epithelial–mesenchymal transition (EMT), fiber formation. summary, long-acting, controllable, release characteristics not only provide an effective strategy preventing but also offer new avenues treating undesirable proliferative conditions ophthalmology beyond.

Язык: Английский

Процитировано

1
Innovative Polymeric Biomaterials for Intraocular Lenses in Cataract Surgery DOI Creative Commons
Kevin Y. Wu,

Rebecca Khammar,

Hormoz Sheikh

и другие.

Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(12), С. 391 - 391

Опубликована: Дек. 23, 2024

Intraocular lenses (IOLs) play a pivotal role in restoring vision following cataract surgery. The evolution of polymeric biomaterials has been central to addressing challenges such as biocompatibility, optical clarity, mechanical stability, and resistance opacification. This review explores essential requirements for IOL biomaterials, emphasizing their ability mitigate complications like posterior capsule opacification (PCO) dysphotopsias while maintaining long-term durability visual quality. Traditional materials, including polymethyl methacrylate (PMMA), silicone, acrylic polymers, are critically analyzed alongside cutting-edge innovations hydrogels, shape memory light-adjustable (LALs). Advances polymer engineering have enabled these materials achieve enhanced flexibility, transparency, driving adoption modern design. Functionalization strategies, surface modifications drug-eluting designs, highlight advancements preventing inflammation, infection, other complications. incorporation UV-blocking blue-light-filtering agents is also examined potential reducing retinal damage. Furthermore, emerging technologies nanotechnology smart polymer-based offer promising avenues personalized, biocompatible IOLs with performance. Clinical outcomes, acuity, contrast sensitivity, patient satisfaction, evaluated provide an understanding the current limitations development. We discuss future directions, underscoring need cost-effective, innovative solutions optimize surgical outcomes improve patients’ quality life.

Язык: Английский

Процитировано

0