MicroRNA in cancer therapy: breakthroughs and challenges in early clinical applications

Journal of Experimental & Clinical Cancer Research, Год журнала: 2025, Номер 44(1)

Опубликована: Апрель 21, 2025

Abstract MicroRNAs (miRNAs) have emerged as pivotal regulators in cancer biology, influencing tumorigenesis, progression, and resistance to therapy. Their ability modulate multiple oncogenic tumor-suppressive pathways positions them promising therapeutic tools or targets. This review examines the dual role of miRNAs solid hematological malignancies, starting from their dysregulation various types. Therapeutic approaches, including miRNA replacement inhibition strategies, are discussed alongside innovative delivery systems such lipid nanoparticles exosomes. Despite transformative potential, challenges persist, off-target effects, immune activation, inefficiencies. Recent clinical trials demonstrate both progress hurdles, underscoring need for advanced strategies optimize specificity minimize toxicity. provides an updated comprehensive overview current landscape miRNA-based therapies under early investigation explores future directions integrating these approaches into precision oncology.

Язык: Английский

---

Enhancement of the in vitro anti-leukemic effect of the histone deacetylase inhibitor Romidepsin using Poly-(D,L-lactide-co-glycolide) nanoparticles as a drug carrier

European Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 107043 - 107043

Опубликована: Фев. 1, 2025

Язык: Английский

---

Advancements in Nanomedicine for the Diagnosis and Treatment of Kidney Stones

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1401 - 1423

Опубликована: Фев. 1, 2025

Abstract: Kidney stones constitute a common condition impacting the urinary system. In clinical diagnosis and management, traditional surgical interventions pharmacological treatments are primarily utilized; however, these methods possess inherent limitations. Presently, field of nanomedicine is undergoing significant advancements. The application nanomaterials in biosensors enables accurate assessment ion composition. Furthermore, contrast agents developed from materials can improve signal-to-noise ratio enhance image clarity. By mitigating oxidative stress-induced cellular damage, inhibit formation kidney efficacy drug delivery as effective carriers. Additionally, by modifying physical chemical properties bacteria, effectively eliminate bacterial presence, thereby preventing severe complications. This review explores advancements technology related to early detection risk factors, diagnosis, treatment their associated Keywords: nanomaterials, stones, stress, biomaterial

Язык: Английский

---

Nanotechnology-based drug delivery for breast cancer treatment: Current applications and future directions

European Journal of Medicinal Chemistry Reports, Год журнала: 2025, Номер unknown, С. 100268 - 100268

Опубликована: Апрель 1, 2025

Язык: Английский

---

β2GPI-targeted polymeric nanoparticles form a protective layer to prevent vascular thrombosis in an anti-phospholipid syndrome model

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 27, 2025

Anti-phospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombotic vascular occlusion and maternal morbidity. Anti-coagulants remain pivotal drugs for the management of APS, but significant proportion patients do not benefit from long-term anti-coagulation may require an alternative therapy to prevent antibody deposition thrombosis. We have developed therapeutic approach based on use safe polymeric nanoparticles that selectively target beta2-glycoprotein I (β2GPI) deposited endothelial cells (tNPs). Their efficacy was tested in rat model APS infusing patients' sera containing medium-high titer antibodies against domain β2GPI. The tNPs bearing CH2-deleted anti-β2GPI recombinant as targeting agent recognize β2GPI failed induce blood clot formation. infused into rats immediately before competed with antibodies, preventing their binding and, consequence, resulted thrombus formations mesenteric vessels. Similar results were obtained injecting 24 hours administration Our findings suggest β2GPI-targeted represent stable formation vessel be used control thrombosis developing result acute triggering events.

Язык: Английский

---

Polymer-Based Designer Particles as Drug Carriers: Strategies to Construct and Modify

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Biological barriers present remarkable challenges for therapeutics delivery, requiring an advanced drug delivery system that can navigate through the complex physiological environment. Polymeric particles provide versatility due to their adaptable physiochemical properties, facilitating new designs address issues. This review focuses on recent advancements in morphology of polymeric emulate biological improve efficacy. It includes how structural engineering─such as designing rod-shaped improved cellular uptake, red-blood-cell-shaped prolonged circulation, worm-shaped carriers tissue penetration, and multicompartmental systems providing combination therapies─profoundly alters capabilities. These designer exhibit enhanced target specificity, controlled release kinetics, therapeutic outcomes relative traditional spherical carriers. particular also emphasizes a polymer chemistry fabrication methods facilitates achieving these structures, while highlighting ongoing scale-up, reproducibility, clinical translations. Through analysis structure-functional property correlations various biomimetic designs, we have attempted insight into future potential transform treatment strategies complicated diseases via shape-directed interactions better outcomes.

Язык: Английский

---

Production of Hydrophobic Microparticles at Safe-To-Inject Sizes for Intravascular Administration

Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 64 - 64

Опубликована: Янв. 6, 2025

Background/Objectives: Hydrophobic microparticles are one of the most versatile structures in drug delivery and tissue engineering. These constructs offer a protective environment for hydrophobic or water-sensitive compounds (e.g., drugs, peroxides), providing an optimal solution numerous biomedical purposes, such as oxygen therapeutics. The intravascular administration requires safe-to-flow particle profile, which typically corresponds to maximum size 5 µm-the generally accepted diameter thinnest blood vessels humans. However, production below this range remains largely unexplored. In work, we investigate fabrication at safe-to-inject sizes (<5 µm) administration. Methods: Polycaprolactone (PCL MPs) produced using double-emulsification method with tip ultrasonication, various parameters molecular weight, PCL concentration, type stabilizer, filtration) optimized obtain particles µm. Results: We achieve MP distribution 99.8% limit, prove that these can flow without obstruction through microfluidic model emulating thin human capillary (4.1 µm × 3.0 width heigh). Conclusions: Overall, demonstrate be fabricated simple scalable setup, paving way towards their applicability new injectables.

Язык: Английский

---

Advanced polymeric systems for colon drug delivery: from experimental models to market applications

Soft Matter, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

In recent years, nano and micro drug delivery systems targeting the colon have gained more attention due to increasing interest in treating diseases such as colorectal cancer inflammatory bowel disease,

Язык: Английский

---

Advances of nanomedicine targeting the interface of cholesterol metabolism and immune evasion

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 110921 - 110921

Опубликована: Фев. 1, 2025

Язык: Английский

---

Sustained Delivery of Liraglutide Using Multivesicular Liposome Based on Mixed Phospholipids

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 203 - 203

Опубликована: Фев. 6, 2025

Background: Although peptides are widely used in the clinical treatment of various diseases due to their strong biological activity, they usually require frequent injections owing poor vivo half-life. Therefore, there is a need for sustained peptide formulations. Methods: In this study, liraglutide (Lir) and biocompatible multivesicular liposomes (MVLs) were utilized as model drug sustained-release carriers, respectively. The release rate Lir-MVLs was controlled by changing ratio SPC DEPC with different phase transition temperatures (PTT, PTTSPC = −20 °C, PTTDEPC 13 °C). Results: As increased, had more flexible lipid membranes, poorer structural stabilization, fewer internal vesicles larger particle sizes, contributing faster Lir. After subcutaneous injection Lir-MVLs, blood glucose concentration (BGC) db/db mice decreased levels. When SPC-DEPC greater than 85:15, too fast; BGC remained below 16 mM only 2–4 days, while when slow, case less 50:50, also 2–3 days. However, 75:25, could be maintained 8 indicating that properties best met pharmacological requirements Conclusions: This study investigated effects phospholipids PTT on characteristics provided ideas design preparations.

Язык: Английский

---