Bioresources and Bioprocessing, Год журнала: 2024, Номер 11(1)

Опубликована: Дек. 25, 2024

Abstract Hyaluronan (HA), a natural high molecular weight polysaccharide, has extensive applications in cosmetology and medical treatment. Hyaluronan-degrading enzymes (Hyals) act as scissors that cleave HA by breaking the glucosidic linkage. Hyals are present diverse organisms, including vertebrates, invertebrates microorganisms, play momentous roles biological processes. In recent years, microbial (mHyals) have gained considerable attention for their exceptional performance production processing of HA. Moreover, mHyals been greatly extended to various biomedical fields. To explore potential mHyals, thorough comprehension is imperative. this context, review systematically summarizes sources, structures, mechanisms enzymatic properties discusses functions host invasion, disease development, regulation intestinal flora. Furthermore, versatile inspired medicine biology, industrial biotechnology comprehensively reviewed. Finally, prospects presented emphasize importance exploration, expression characterization necessity excavating biotechnological Graphical abstract

Язык: Английский