Advancing Organ-on-a-Chip Systems: The Role of Scaffold Materials and Coatings in Engineering Cell Microenvironment DOI Open Access

Guido Andrés Ramírez-González,

Chiara Consumi-Tubito,

Ernesto Vargas-Méndez

и другие.

Polymers, Год журнала: 2025, Номер 17(9), С. 1263 - 1263

Опубликована: Май 6, 2025

For organ-on-a-chip (OoC) engineering, the use of biocompatible coatings and materials is not only recommended but essential. Extracellular matrix (ECM) components are commonly used as due to their effects on cell orientation, protein expression, differentiation, adhesion. Among most frequently collagen, fibronectin, Matrigel, according specific type intended OoC application. Additionally, such polydimethylsiloxane (PDMS), thermoplastics, chitosan, alginate serve scaffolding biomechanical properties biocompatibility. Here, we discuss some employed coating techniques, including SAMs, dip coating, spin microcontact printing, 3D bioprinting, each offering advantages drawbacks. Current challenges comprise enhancing biocompatibility, exploring novel materials, improving scalability reproducibility.

Язык: Английский

Advanced microfluidic strategies for core-shell nanoparticles: the next-generation of polymeric and lipid-based drug nanocarriers DOI Creative Commons

Giuseppe Nunziata,

Alessandro Borroni,

Filippo Rossi

и другие.

Chemical Engineering Journal Advances, Год журнала: 2025, Номер unknown, С. 100759 - 100759

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Advancing Organ-on-a-Chip Systems: The Role of Scaffold Materials and Coatings in Engineering Cell Microenvironment DOI Open Access

Guido Andrés Ramírez-González,

Chiara Consumi-Tubito,

Ernesto Vargas-Méndez

и другие.

Polymers, Год журнала: 2025, Номер 17(9), С. 1263 - 1263

Опубликована: Май 6, 2025

For organ-on-a-chip (OoC) engineering, the use of biocompatible coatings and materials is not only recommended but essential. Extracellular matrix (ECM) components are commonly used as due to their effects on cell orientation, protein expression, differentiation, adhesion. Among most frequently collagen, fibronectin, Matrigel, according specific type intended OoC application. Additionally, such polydimethylsiloxane (PDMS), thermoplastics, chitosan, alginate serve scaffolding biomechanical properties biocompatibility. Here, we discuss some employed coating techniques, including SAMs, dip coating, spin microcontact printing, 3D bioprinting, each offering advantages drawbacks. Current challenges comprise enhancing biocompatibility, exploring novel materials, improving scalability reproducibility.

Язык: Английский

Процитировано

0