Proteomic reference map for sarcopenia research: mass spectrometric identification of key muscle proteins located in the sarcomere, cytoskeleton and the extracellular matrix DOI
Paul Dowling, Stephen Gargan, Margit Zweyer

и другие.

European Journal of Translational Myology, Год журнала: 2024, Номер unknown

Опубликована: Май 24, 2024

Sarcopenia of old age is characterized by the progressive loss skeletal muscle mass and concomitant decrease in contractile strength. Age-related dysfunctions play a key pathophysiological role frailty syndrome can result drastically diminished quality life elderly. Here we have used spectrometric analysis mouse hindlimb musculature to establish protein constellation at advanced widely sarcopenic animal model. Proteomic results were further analyzed systems bioinformatics voluntary muscles. In this report, proteomic survey aged muscles has focused on expression patterns proteins involved contraction-relaxation cycle, membrane cytoskeletal maintenance formation extracellular matrix. This includes markers fast versus slow phenotypes myosin-containing thick filaments actin-containing thin filaments, as well that are associated with non-sarcomeric cytoskeleton various matrisomal layers. The bioanalytical usefulness newly established reference map was demonstrated comparative screening normal dystrophic age, findings verified immunoblot analysis.

Язык: Английский

A Multi-Omics-Empowered Framework for Precision Diagnosis and Treatment of Lysosomal Diseases DOI Creative Commons
Nguyen Thi Hai Yen,

Nguyen Tran Nam Tien,

Nguyen Quang Thu

и другие.

Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101274 - 101274

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Proteomic reference map for sarcopenia research: mass spectrometric identification of key muscle proteins located in the sarcomere, cytoskeleton and the extracellular matrix DOI
Paul Dowling, Stephen Gargan, Margit Zweyer

и другие.

European Journal of Translational Myology, Год журнала: 2024, Номер unknown

Опубликована: Май 24, 2024

Sarcopenia of old age is characterized by the progressive loss skeletal muscle mass and concomitant decrease in contractile strength. Age-related dysfunctions play a key pathophysiological role frailty syndrome can result drastically diminished quality life elderly. Here we have used spectrometric analysis mouse hindlimb musculature to establish protein constellation at advanced widely sarcopenic animal model. Proteomic results were further analyzed systems bioinformatics voluntary muscles. In this report, proteomic survey aged muscles has focused on expression patterns proteins involved contraction-relaxation cycle, membrane cytoskeletal maintenance formation extracellular matrix. This includes markers fast versus slow phenotypes myosin-containing thick filaments actin-containing thin filaments, as well that are associated with non-sarcomeric cytoskeleton various matrisomal layers. The bioanalytical usefulness newly established reference map was demonstrated comparative screening normal dystrophic age, findings verified immunoblot analysis.

Язык: Английский

Процитировано

1