Unlocking the Potential of RNA Sequencing in COVID-19: Toward Accurate Diagnosis and Personalized Medicine
Diagnostics,
Год журнала:
2025,
Номер
15(2), С. 229 - 229
Опубликована: Янв. 20, 2025
COVID-19
has
caused
widespread
morbidity
and
mortality,
with
its
effects
extending
to
multiple
organ
systems.
Despite
known
risk
factors
for
severe
disease,
including
advanced
age
underlying
comorbidities,
patient
outcomes
can
vary
significantly.
This
variability
complicates
efforts
predict
disease
progression
tailor
treatment
strategies.
While
diagnostic
therapeutic
approaches
are
still
under
debate,
RNA
sequencing
(RNAseq)
emerged
as
a
promising
tool
provide
deeper
insights
into
the
pathophysiology
of
guide
personalized
treatment.
A
comprehensive
literature
review
was
conducted
using
PubMed,
Scopus,
Web
Science,
Google
Scholar.
We
employed
Medical
Subject
Headings
(MeSH)
terms
relevant
keywords
identify
studies
that
explored
role
RNAseq
in
diagnostics,
prognostics,
therapeutics.
proven
instrumental
identifying
molecular
biomarkers
associated
severity
patients
COVID-19.
It
allows
differentiation
between
asymptomatic
symptomatic
individuals
sheds
light
on
immune
response
mechanisms
contribute
progression.
In
critically
ill
patients,
been
crucial
key
genes
may
outcomes,
guiding
decisions,
assessing
long-term
virus.
Additionally,
helped
understanding
persistence
viral
after
recovery,
offering
new
management
post-acute
sequelae,
long
COVID.
significantly
improves
management,
particularly
by
enhancing
accuracy,
personalizing
treatment,
predicting
responses.
refines
stratification,
improving
holds
promise
targeted
interventions
both
acute
Язык: Английский
Omics for searching plasma biomarkers associated with unfavorable COVID-19 progression in hypertensive patients
Alba Sánchez,
Graciano García‐Pardo,
Anna Martí
и другие.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 25, 2025
Hypertension
is
one
of
the
most
common
risk
factors
for
COVID-19
clinical
progression.
The
identification
plasma
biomarkers
anticipating
worse
outcomes
and
to
better
understand
shared
mechanisms
between
hypertension
are
needed.
A
hypothesis-generating
study
was
designed
compare
proteomics
metabolomics
22
hypertensives
(HT)
41
non-hypertensives
(nHT)
patients
with
unfavorable
total
43
molecules
were
significantly
differed
HT
(n
=
22)
nHT
41).
Random
Forest
(RF)
analysis
identified
myo-inositol,
gelsolin
phosphatidylcholine
(PC)
32:1
as
top
distinguishing
nHT.
Plasma
myo-inositol
higher
(P
0.03
P
0.02,
respectively)
PC
lower
0.03)
in
compared
Biological
processes
like
stress
response
blood
coagulation,
along
KEGG
pathways
including
ascorbate
aldarate
metabolism
0.021)
linoleic
acid
0.028),
altered
hypertensive
There
a
clear
link
severe
COVID-19.
Key
biological
consider
improving
prognosis
quality
life
who
become
infected
SARS-CoV-2
include
oxidative
stress,
metabolism,
lipid
immune
system
inflammation.
Язык: Английский
Molecular Diagnostics of Cryptococcus spp. and Immunomics of Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome
Diseases,
Год журнала:
2024,
Номер
12(5), С. 101 - 101
Опубликована: Май 13, 2024
Cryptococcal
infection
poses
a
significant
global
public
health
challenge,
particularly
in
regions
near
the
equator.
In
this
review,
we
offer
succinct
exploration
of
Cryptococcus
spp.
genome
and
various
molecular
typing
methods
to
assess
burden
genetic
diversity
cryptococcal
pathogens
environment
clinical
isolates.
We
delve
into
detailed
discussion
on
pathogenesis
diagnosis
immune
reconstitution
inflammatory
syndrome
(IRIS)
associated
with
cryptococcosis,
specific
emphasis
meningitis
IRIS
(CM-IRIS).
Our
examination
includes
recent
literature
CM-IRIS,
covering
host
cellulomics,
proteomics,
transcriptomics,
genomics.
Язык: Английский
Vaccinomics: Paving the Way for Personalized Immunization
Current Pharmaceutical Design,
Год журнала:
2023,
Номер
30(13), С. 1031 - 1047
Опубликована: Дек. 27, 2023
Abstract:
Vaccines
are
one
of
the
most
important
medical
advancements
in
human
history.
They
have
been
successfully
used
to
control
and
limit
spread
many
lethal
diseases
that
plagued
us,
such
as
smallpox
polio.
Previous
vaccine
design
methodologies
were
based
on
model
"isolate-inactivate
inject",
which
amounts
giving
same
dose
everyone
susceptible
infection.
In
recent
years,
importance
how
host
genetic
background
alters
response
necessitated
introduction
vaccinomics,
is
aimed
at
studying
variability
efficacy
by
associating
immune
vaccination.
Despite
rapid
developments
variant
screening,
data
obtained
from
association
studies
often
inconclusive
cannot
be
guide
new
generation
vaccines.
This
review
aims
compile
polymorphisms
HLA
system
genes
examine
link
with
their
The
compiled
can
development
strategies
for
vaccination
vulnerable
groups.
Overall,
highly
polymorphic
locus
had
highest
correlation
studied
vaccines,
it
was
linked
variation
multiple
stages
vaccines
both
humoral
cellular
immunity.
Designing
technologies
immunization
regiments
accommodate
this
an
step
reaching
a
vaccinomics-based
approach
Язык: Английский