MIPs
inspired
by
antigen-antibody
interactions
have
received
substantial
interest
as
a
biomimetic
artificial
receptor
system
in
environmental
applications.
Herein,
we
present
molecularly
imprinted
surface
plasmon
resonance
(SPR)
sensor
integrated
with
Au
nanoparticles
for
the
identification
of
bisphenol
A
(BPA),
an
endocrine-disrupting
chemical.
The
synthetic
wastewater
samples
were
analyzed
to
ensure
method's
reliability
and
feasibility.
Under
ideal
conditions,
suggested
approach
performed
well
terms
analytical
performance
BPA,
wide
linear
range
0.1
10
ppb
LOD
ng/L.
results
Langmuir
adsorption
model
good
agreement.
It
has
also
been
shown
that
repeated
use
biosensor
can
be
achieved.
According
selectivity
studies,
BPA
adsorbed
within
cavities
favorably
compared
4-nitrophenol
phenol.
produced
BPA-imprinted
SPR
provides
improved
sensitivity
based
on
signal
amplification
strategy,
unconjugated
sensing
without
need
labeling,
real-time
sensing,
low
sample
consumption
rates,
quantifiable
assessment,
very
kinetic
rate
constant
calculation
actual
samples.
Also,
because
is
reusable
relative
standard
deviations
(RSD)<1.25,
indicating
sensor's
accuracy,
SPR-based
simple
practice
may
economical
option.
Abstract
Herein,
an
innovative
glyphosate
imprinted
poly(hydroxyethyl
methacrylate-N-methacroyl-(L)-phenylalanine
methyl
ester
nanoparticles
(MIP@NPs)
based
plasmonic
nanosensor
featured
with
high
sensitivity
and
selectivity
was
constructed
by
using
the
molecular
imprinting
technique
used
for
real-time
detection.
The
characterization
of
performed
nano
Zetasizer
scanning
electron
microscopy
(SEM),
while
nanosensors
were
characterized
Fourier
transform
infrared-attenuated
total
reflection
(FTIR-ATR)
contact
angle
measurement.
Control
experiments
conducted
to
evaluate
efficiency
on
signal
response
a
non-imprinted
surface
plasmon
resonance
(NIP
SPR)
prepared
without
adding
pesticide
into
polymerization
mixture.
MIP@NPs
integrated
molecularly
(MIP
having
synthetic
recognition
elements
yielded
novel
biosensing
platform
label-free
detection
monitoring
pesticide.
MIP
SPR
detected
target
molecule
4.950
times
more
selectively
than
competitor
malathion
3.918
malaoxon.
In
addition,
factor
found
be
6.76,
indicating
that
process
successful.
6.76.
Kinetic
studies
adsorption
characteristics
glycosate
carried
out
assess
dynamics.
linear
concentration
range
0.001
ppm–10.000
ppm
pesticide,
limit
0.120
ppb.
Studies
repeatability
revealed
even
after
five
cycles,
did
not
change
significantly
relative
standard
deviation,
RSD<1.5
value.
artificial
urine
selected
as
real
sample
spiked
at
final
10.000
matrix
effect,
amount
reported.
The Analyst,
Год журнала:
2024,
Номер
149(15), С. 4020 - 4028
Опубликована: Янв. 1, 2024
Reagentless
molecular-imprinted
polymer
(MIP)
electrochemical
biosensors
can
offer
the
next
generation
of
biosensing
platforms
for
detection
biomarkers
owing
to
their
simplicity,
cost-efficacy,
tunability,
robustness,
and
accuracy.
In
this
work,
a
novel
combination
Prussian
blue
(PB),
coated
as
an
embedded
redox
probe
on
gold
working
electrode
(GWE),
signal-off
MIP
assay
has
been
proposed
in
format
troponin
I
(TnI)
biofluids.
TnI
is
variant
exclusive
heart
muscles,
its
elevated
level
bloodstream
indicative
acute
myocardial
infarction
(AMI).
The
lab-manufactured
PB/MIP
biosensor,
consisting
simple
PB
GWE
surface,
first
kind
that
allows
reagentless,
label-free,
single-step
proteins.
preparation
steps
biosensor
were
fully
characterized
by
cyclic
voltammetry
(CV),
atomic
force
microscopy
(AFM),
Raman
spectroscopy.
Finally,
performance
optimized
was
investigated
through
determination
various
concentrations
TnI,
ranging
from
10
100
pg
mL
Current Nanoscience,
Год журнала:
2024,
Номер
21(3), С. 470 - 480
Опубликована: Март 25, 2024
The
remarkable
physicochemical
properties
of
Graphene
oxide
(GO),
a
graphene
derivative,
have
made
it
material
with
intriguing
medical
administration
potential.
Its
2D
allotropic
nature
is
the
source
its
biological
flexibility.
transportation
genes
and
small
molecules
are
just
two
many
biomedical
applications
composite.
Antibacterial
use
in
tooth
bone
grafts,
biofunctionalization
proteins,
treatment
cancer
among
other
potential
uses.
biocompatibility
freshly
synthesized
nanomaterials
opens
up
world
medicinal
Furthermore,
GO's
versatility
makes
an
ideal
component
for
usage
drug
delivery
systems,
such
as
hydrogels,
nanoparticles,
micelles.
This
review
aims
to
compile
existing
body
knowledge
regarding
GO
by
delving
into
uses,
obstacles,
future
developments.
