Simultaneous assessment of mitochondrial and vascular function using the Flow Mediated Skin Fluorescence technique
Frontiers in Physiology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 19, 2025
Flow
Mediated
Skin
Fluorescence
(FMSF)
is
a
new
non-invasive
diagnostic
method
for
assessing
vascular
circulation
and/or
metabolic
regulation.
The
measures
stimulation
of
the
in
response
to
post-occlusive
reactive
hyperemia
(PORH).
It
analyzes
dynamical
changes
NADH
fluorescence
emitted
from
skin
tissue,
providing
information
on
mitochondrial
status
and
intracellular
oxygen
delivery
through
circulatory
system.
Assessment
state
using
FMSF
technique
based
three
parameters:
flowmotion
(FM)
under
normoxia
conditions,
hypoxia
sensitivity
(HS),
hyperemic
(HRmax).
functioning
mitochondria
can
be
assessed
by
analyzing
ischemic
(IRmax),
basal
level
fluorescence.
There
close
relationship
between
Despite
these
interactions,
regulatory
function
monitored
separately
as
well
simultaneously
technique.
Uniquely,
this
approach
delivers
both
single
measurement.
Язык: Английский
A New Approach to the Assessment of Erectile Dysfunction Based on Vasomotion Monitored by the Flow-Mediated Skin Fluorescence (FMSF) Technique—A Preliminary Study
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(11), С. 3210 - 3210
Опубликована: Май 30, 2024
Background:
Erectile
dysfunction
(ED)
most
often
has
vascular
etiology
and
usually
is
the
earliest
symptom
of
dysfunction.
The
aim
this
study
was
to
evaluate
with
use
Flow-Mediated
Skin
Fluorescence
(FMSF)
technique
in
men
without
ED.
Methods:
Included
were
39
(median
age
53)
ED
40
41.5)
Medical
interview,
physical
examination,
anthropometrical
measurements
performed
for
all
participants.
serum
total
testosterone,
LH,
SHBG
determinations
patients
ED,
Free
Testosterone
Index
(FTI)
calculated.
FMSF
used
measure
microcirculatory
oscillations
at
baseline
determine
flowmotion
(FM)
vasomotion
(VM)
parameters.
Normoxia
Oscillatory
(NOI)
calculated,
which
represents
contribution
endothelial
(ENDO)
neurogenic
(NEURO)
relative
detected
low-frequency
intervals
(<0.15
Hz):
NOI
=
(ENDO
+
NEURO)/(ENDO
NEURO
VM).
Results:
In
found
significantly
lower
FM
VM
parameters,
but
higher
comparison
correlated
positively
erectile
function,
orgasmic
general
sexual
satisfaction
whole
group
FTI
group.
thresholds
53.5
(AUC
0.7)
8.4
predictive
values
discriminating
Conclusions:
It
shown
that
diagnostic
may
be
helpful
early
diagnosis
microcirculation
due
impaired
caused
by
decreased
testosterone
activity.
Язык: Английский
Assessment of Microvascular Function Based on Flowmotion Monitored by the FMSF Technique
Опубликована: Авг. 29, 2024
This
review
summarizes
studies
dedicated
to
the
assessment
of
microvascular
function
based
on
microcirculatory
oscillations
monitored
by
FMSF
technique.
Two
approaches
are
presented.
The
first
approach
uses
oscillatory
parameters
measured
under
normoxia
conditions,
expressed
as
flowmotion
(FM),
vasomotion
(VM),
and
index
(NOI).
These
have
been
used
for
identification
impaired
associated
with
intense
physical
exercise,
post-COVID
syndrome,
psychological
stress,
erectile
dysfunction.
second
involves
characterization
response
hypoxia
measurement
sensitivity
(HS).
HS
parameter
is
characterize
complications
in
diabetes,
such
diabetic
kidney
disease
foot
ulcers.
Based
research
conducted
authors
this
review,
ranges
characterizing
diagnostic
assessing
technique
has
a
wide
range
applications
potential
be
integrated
into
widespread
medical
practice.
Язык: Английский
Assessment of Microvascular Function Based on Flowmotion Monitored by the Flow-Mediated Skin Fluorescence Technique
Biosensors,
Год журнала:
2024,
Номер
14(10), С. 459 - 459
Опубликована: Сен. 25, 2024
This
review
summarizes
studies
dedicated
to
the
assessment
of
microvascular
function
based
on
microcirculatory
oscillations
monitored
by
Flow-Mediated
Skin
Fluorescence
(FMSF)
technique.
Two
approaches
are
presented.
The
first
approach
uses
oscillatory
parameters
measured
under
normoxic
conditions,
expressed
as
flowmotion
(FM),
vasomotion
(VM),
and
normoxia
index
(NOI).
These
have
been
used
for
identification
impaired
associated
with
intense
physical
exercise,
post-COVID
syndrome,
psychological
stress,
erectile
dysfunction.
second
involves
characterization
response
hypoxia
measurement
sensitivity
(HS).
HS
parameter
is
characterize
complications
in
diabetes,
such
diabetic
kidney
disease
foot
ulcers.
Based
research
conducted
authors
this
review,
FMSF
ranges
characterizing
diagnostic
assessing
technique
has
a
wide
range
applications
potential
be
integrated
into
widespread
medical
practice.
Язык: Английский