Lovastatin and Resveratrol Synergistically Improve Wound Healing and Inhibit Bacterial Growth DOI Open Access

Norah A. AlJunaydil,

Rhodanne Lambarte, Terrence S. Sumague

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 851 - 851

Опубликована: Янв. 20, 2025

Wound healing is a complex physiological process, with scarring and infection caused by Staphylococcus aureus Pseudomonas aeruginosa being the most common complications. The reutilization of known medications has received increased attention for their role in cell function as small molecules. Examples these include lovastatin, cholesterol-lowering agent, resveratrol, which have multiple biological properties. Both molecules been reported to improve wound possess antibacterial properties, conflicting results. wound-healing capabilities human mesenchymal stem cells were evaluated after exposure combination through scratch test, migrations assay, qPCR. Protein docking was performed assess lovastatin/resveratrol potential targets. AlamarBlue assay used determine viability. Additionally, impact lovastatin resveratrol inhibit growth S. P. tested using broth microdilution test checkerboard synergism. 0.1 μM synergistically improved demonstrated an additive effect against aeruginosa, presenting applications.

Язык: Английский

Lovastatin and Resveratrol Synergistically Improve Wound Healing and Inhibit Bacterial Growth DOI Open Access

Norah A. AlJunaydil,

Rhodanne Lambarte, Terrence S. Sumague

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 851 - 851

Опубликована: Янв. 20, 2025

Wound healing is a complex physiological process, with scarring and infection caused by Staphylococcus aureus Pseudomonas aeruginosa being the most common complications. The reutilization of known medications has received increased attention for their role in cell function as small molecules. Examples these include lovastatin, cholesterol-lowering agent, resveratrol, which have multiple biological properties. Both molecules been reported to improve wound possess antibacterial properties, conflicting results. wound-healing capabilities human mesenchymal stem cells were evaluated after exposure combination through scratch test, migrations assay, qPCR. Protein docking was performed assess lovastatin/resveratrol potential targets. AlamarBlue assay used determine viability. Additionally, impact lovastatin resveratrol inhibit growth S. P. tested using broth microdilution test checkerboard synergism. 0.1 μM synergistically improved demonstrated an additive effect against aeruginosa, presenting applications.

Язык: Английский

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