Aggravated Visual Toxicity in Zebrafish Larvae Upon Co-Exposure to Titanium Dioxide Nanoparticles and Bis(2-Ethylhexyl)-2,3,4,5-Tetrabromophthalate DOI
Yuxi Zhou, Lei Lei, Biran Zhu

и другие.

Опубликована: Янв. 1, 2023

The bioavailability and toxicity of organic pollutants in aquatic organisms can be largely affected by the co-existed nanoparticles. However, impacts such combined exposure on visual system remain unknown. Here, we systematically investigated zebrafish larvae after single or joint to titanium dioxide nanoparticles (n-TiO2) bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH) at environmentally relevant levels. Molecular dynamics simulations revealed enhanced transmembrane capability complex than individual, which accounted for increased both TBPH n-TiO2 when zebrafish. Transcriptome analysis showed that co-exposure interfered with molecular pathways related eye lens structure sensory perception Particularly, significantly suppressed expression βB1-crystallin rhodopsin retina lens, was further co-exposure. Moreover, detected disorganized retinal histology, stunted development significant behavioral changes under condition. overall results suggest water borne their bioavailability, resulted severer damage optic nerve ultimately abnormal behavior patterns, highlighting higher potential health risks vertebrates.

Язык: Английский

Bioaccumulation and Trophodynamics of Novel Brominated Flame Retardants (NBFRs) in Marine Food Webs from the Arctic and Antarctic Regions DOI

Siyuan Xiong,

Jianjie Fu, Cheng Dong

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(15), С. 6804 - 6813

Опубликована: Март 21, 2024

The pervasive contamination of novel brominated flame retardants (NBFRs) in remote polar ecosystems has attracted great attention recent research. However, understanding regarding the trophic transfer behavior NBFRs Arctic and Antarctic marine food webs is limited. In this study, we examined occurrence trophodynamics benthic sediment collected from areas around Chinese Yellow River Station (n = 57) Great Wall 94). ∑7NBFR concentrations were range 1.27–7.47 ng/g lipid weight (lw) 0.09–1.56 lw biota, respectively, among which decabromodiphenyl ethane (DBDPE) was predominant compound all sample types. biota–sediment bioaccumulation factors (g total organic carbon/g lipid) (0.85–3.40) 4-fold higher than those Antarctica (0.13–0.61). Trophic magnification (TMFs) their 95% confidence interval (95% CI) individual ranged 0.43 CI: 0.32, 0.60) to 1.32 (0.92, 1.89) 0.34 (0.24, 0.49) 0.92 (0.56, 1.51) webs, respectively. TMFs most congeners significantly lower 1, indicating a dilution potential. This one very few investigations on ecosystems, provides basis for exploring ecological risks regions.

Язык: Английский

Процитировано

11

Environmental impacts of polymeric flame retardant breakdown DOI
Xiaotu Liu, Yuanyuan Xiong, Xiao Gou

и другие.

Nature Sustainability, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Язык: Английский

Процитировано

2

Eight novel brominated flame retardants in indoor and outdoor dust samples from the E-waste recycling industrial park: Implications for human exposure DOI
Yongyin Lan, Yuxian Liu, Yanpeng Cai

и другие.

Environmental Research, Год журнала: 2023, Номер 238, С. 117172 - 117172

Опубликована: Сен. 18, 2023

Язык: Английский

Процитировано

19

Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Enhances foxo1-Mediated Lipophagy to Remodel Lipid Metabolism in Zebrafish Liver DOI
Yuxi Zhou, Fan Li,

Kaiyu Fu

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(10), С. 4581 - 4593

Опубликована: Фев. 29, 2024

An emerging environmental contaminant, bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH), can bioaccumulate in the liver and affect hepatic lipid metabolism. However, in-depth mechanism has yet to be comprehensively explored. In this study, we utilized transgenic zebrafish Tg (Apo14: GFP) image interference of TBPH on development metabolism at early stage. Using integrated lipidomic transcriptomic analyses profile remodeling effect, uncovered potential effects lipophagy-related signaling pathways larvae. Decreased contents accompanied by enhanced lipophagy were confirmed measurements Oil Red O staining transmission electron microscopy tissues. Particularly, regulatory role foxo1 factor was validated via its transcriptional inhibitor. Double immunofluorescence with biochemical analysis indicated that mitochondrial fatty acid oxidation induced reversed To summarize, our study reveals, for first time, essential foxo1-mediated TBPH-induced metabolic disorders hepatoxicity, providing new insights disease studies ecological health risk assessment TBPH.

Язык: Английский

Процитировано

9

Aggravated visual toxicity in zebrafish larvae upon co-exposure to titanium dioxide nanoparticles and bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate DOI
Yuxi Zhou, Lei Lei, Biran Zhu

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 921, С. 171133 - 171133

Опубликована: Фев. 22, 2024

Язык: Английский

Процитировано

6

From e-waste to living space: flame retardants contaminating household items add to concern about plastic recycling DOI

Mingyu Liu,

S. Brandsma, Erika Schreder

и другие.

Chemosphere, Год журнала: 2024, Номер unknown, С. 143319 - 143319

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

4

Novel Flame Retardants (NFRs) in E-waste: Environmental burdens, health implications, and recommendations for safety assessment and sustainable management DOI Creative Commons

Obianuju Oluchukwu Eze,

Emeka Bright Ogbuene,

Omodele Ibraheem

и другие.

Toxicology, Год журнала: 2024, Номер unknown, С. 154037 - 154037

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1

Long-Term Polyethylene (Bio)Degradation in Landfill: Environmental and Human Health Implications from Comprehensive Analysis DOI Creative Commons
Vladyslav Redko, Lidia Wolska, Ewa Olkowska

и другие.

Molecules, Год журнала: 2024, Номер 29(11), С. 2499 - 2499

Опубликована: Май 25, 2024

This study investigates the process of long-term (bio)degradation polyethylene (PE) in an old municipal waste landfill (MWL) and its implications for environmental human health. Advanced techniques, such as ICP–ES/MS IC–LC, were used to analyze heavy metals anions/cations, demonstrating significant concentration deviations from control samples. The soil’s chemical composition revealed numerous hazardous organic compounds, further indicating migration additives PE soil. Toxicological assessments, including Phytotoxkit FTM, Microtox® bioassay, Ostracodtoxkit®, demonstrated phytotoxicity, acute toxicity, high mortality living organisms (over 85% Heterocypris Incongruens). An unusual contaminants MWL’s middle layers, linked Poland’s economic changes during 1980s 1990s, suggests increased risks pollutant migration, posing additional health threats. Moreover, infiltration capability microorganisms, pathogens, into structures raises concerns about potential groundwater contamination through bottom. research underscores need vigilant management updated strategies protect environment public health, particularly older sites.

Язык: Английский

Процитировано

0

Aggravated Visual Toxicity in Zebrafish Larvae Upon Co-Exposure to Titanium Dioxide Nanoparticles and Bis(2-Ethylhexyl)-2,3,4,5-Tetrabromophthalate DOI
Yuxi Zhou, Lei Lei, Biran Zhu

и другие.

Опубликована: Янв. 1, 2023

The bioavailability and toxicity of organic pollutants in aquatic organisms can be largely affected by the co-existed nanoparticles. However, impacts such combined exposure on visual system remain unknown. Here, we systematically investigated zebrafish larvae after single or joint to titanium dioxide nanoparticles (n-TiO2) bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH) at environmentally relevant levels. Molecular dynamics simulations revealed enhanced transmembrane capability complex than individual, which accounted for increased both TBPH n-TiO2 when zebrafish. Transcriptome analysis showed that co-exposure interfered with molecular pathways related eye lens structure sensory perception Particularly, significantly suppressed expression βB1-crystallin rhodopsin retina lens, was further co-exposure. Moreover, detected disorganized retinal histology, stunted development significant behavioral changes under condition. overall results suggest water borne their bioavailability, resulted severer damage optic nerve ultimately abnormal behavior patterns, highlighting higher potential health risks vertebrates.

Язык: Английский

Процитировано

0