bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 31, 2023
Abstract
Per-
and
Polyfluoroalkyl
substances
(PFAS)
have
been
widely
used
in
various
industries,
including
pesticide
production,
electroplating,
packaging,
paper
making,
the
manufacturing
of
water-resistant
clothes.
This
study
investigates
levels
PFAS
fish
tissues
collected
from
four
target
waterways
(15
sampling
points)
northwestern
part
Illinois
during
2021-2022.
To
assess
accumulation,
concentrations
17
compounds
were
evaluated
nine
species
to
potentially
inform
on
exposure
risks
local
sport
fishing
population
via
consumption.
At
least
(PFHxA,
PFHxS,
PFOS,
PFBS)
detected
at
each
site.
The
highest
consistently
found
samples
Rock
River,
particularly
areas
near
urban
industrial
activities.
PFHxA
emerged
as
most
accumulated
year
2022,
while
PFBS
PFOS
dominated
2021.
Channel
Catfish
exhibited
content
across
different
species,
indicating
its
bioaccumulation
potential
food
chain.
Elevated
observed
nearly
all
fish,
need
for
careful
consideration
Additional
data
future
years
is
needed
shed
light
sources
accumulation
aquatic
wildlife
relation
exposures
health
risk
assessment.
Journal of Exposure Science & Environmental Epidemiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Abstract
Background
Exposure
to
per-
and
polyfluoroalkyl
substances
(PFAS)
has
been
linked
with
various
cancers.
Assessment
of
PFAS
in
drinking
water
cancers
can
help
inform
biomonitoring
prevention
efforts.
Objective
To
screen
for
incident
cancer
(2016–2021)
assess
associations
contamination
the
US.
Methods
We
obtained
county-level
age-adjusted
incidence
from
Surveillance,
Epidemiology,
End
Results
(SEER)
Program.
Data
on
levels
public
systems
were
Third
(UCMR3;
2013–2015)
Fifth
(UCMR5;
2023–2024)
Unregulated
Contaminant
Monitoring
Rule.
UCMR3
measured
PFOS,
PFOA,
PFNA,
PFHxS,
PFHpA,
PFBS.
UCMR5
expanded
measurements
include
PFBA,
PFHxA,
PFPeA,
PFPeS.
created
indicators
detection
and,
UCMR5,
concentrations
above
Maximum
Levels
(MCLs).
MCLs
PFOA
PFOS
are
4
ng/L,
PFNA
PFHxS
10
ng/L.
used
Poisson
regression
models
between
or
MCL
violation
incidence,
adjusting
potential
confounders.
estimated
number
attributable
cases.
was
associated
increased
digestive,
endocrine,
oral
cavity/pharynx,
respiratory
systems.
Incidence
rate
ratios
(IRRs)
ranged
1.02
1.33.
The
strongest
association
observed
PFBS
cavity/pharynx
(IRR:
1.33
[1.04,
1.71]).
Among
males,
urinary,
brain,
leukemia,
soft
tissues.
females,
thyroid,
tissue.
is
contribute
4626
[95%
CI:
1,377,
8046]
cases
per
year
based
data
6864
991,
12,804]
UCMR5.
Impact
statement
ecological
study
examined
two
waves
(2013–2015
2016
2021.
found
that
organ
system
including
lung,
digestive
system,
urinary
tissue,
thyroid.
Some
have
not
widely
studied
their
PFAS.
also
sex
differences
risks.
This
first
exposure
Toxics,
Год журнала:
2024,
Номер
12(1), С. 39 - 39
Опубликована: Янв. 3, 2024
This
review
presents
a
new
perspective
on
the
exacerbation
of
autism
spectrum
disorder
(ASD)
by
per-
and
polyfluoroalkyl
substances
(PFAS)
through
gut-liver-brain
axis.
We
have
summarized
evidence
reported
involvement
gut
microbiome
liver
inflammation
that
led
to
onset
ASD
symptoms.
As
PFAS
are
toxicants
particularly
target
liver,
this
has
comprehensively
explored
possible
interaction
between
acetaminophen,
another
toxicant,
as
chemicals
interest
for
future
toxicology
research.
Our
hypothesis
is
that,
at
acute
dosages,
acetaminophen
ability
aggravate
impaired
conditions
PFAS-exposed
which
would
further
exacerbate
neurological
symptoms
such
lack
social
communication
interest,
repetitive
behaviors
using
mechanisms
related
discusses
their
potential
interactions
in
terms
axis
signaling
pathways
may
contribute
diseases.
Environment International,
Год журнала:
2024,
Номер
185, С. 108556 - 108556
Опубликована: Март 1, 2024
Lithium
Bis(trifluoromethanesulfonyl)imide
(LiTFSI
ie.
HQ-115),
a
polymer
electrolyte
used
in
energy
applications,
has
been
detected
the
environment,
yet
its
health
risks
and
environmental
epigenetic
effects
remain
unknown.
This
study
aims
to
unravel
potential
associated
with
LiTFSI,
investigate
role
of
DNA
methylation-induced
toxic
mechanisms
effects,
compare
hepatotoxic
impact
well-studied
Perfluorooctanoic
Acid
(PFOA).
Using
murine
model,
six-week-old
male
CD1
mice
were
exposed
10
20
mg/kg/day
each
chemical
for
14
days
as
14-day
exposure
1
5
30
30-day
exposure.
Results
indicate
that
PFOA
induced
significant
hepatotoxicity,
characterized
by
liver
enlargement,
elevated
serum
biomarkers.
In
contrast,
LiTFSI
showed
lower
accompanied
mild
injuries.
Despite
higher
bioaccumulation
serum,
exhibited
similar
range
concentrations
compared
PFOA.
Reduced
Representative
Bisulfite
Sequencing
(RRBS)
analysis
revealed
distinct
methylation
patterns
between
two
compounds.
Both
implicated
inflammatory
pathways
lipid
metabolism.
Transcriptional
results
differentially
methylated
regions
both
exposures
are
enriched
cancer/disease-related
motifs.
Furthermore,
Peroxisome
proliferator-activated
receptor
alpha
(PPARα),
regulator
metabolism,
was
upregulated
exposures,
downstream
genes
indicating
oxidative
damages.
Overall,
exhibits
hepatotoxicity
profiles,
emphasizing
need
comprehensive
assessment
emerging
PFAS
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 15, 2024
Abstract
Fluorinated
compounds
are
used
for
agrochemical,
pharmaceutical,
and
numerous
industrial
applications,
resulting
in
global
contamination.
In
many
molecules,
fluorine
is
incorporated
to
enhance
the
half-life
improve
bioavailability.
enter
human
body
through
food,
water,
xenobiotics
including
pharmaceuticals,
exposing
gut
microbes
these
substances.
The
microbiota
known
its
xenobiotic
biotransformation
capabilities,
but
it
was
not
previously
whether
microbial
enzymes
could
break
carbon-fluorine
bonds,
potentially
altering
toxicity
of
compounds.
Here,
development
a
rapid,
miniaturized
fluoride
detection
assay
whole-cell
screening,
we
discovered
active
defluorinases.
We
biochemically
characterized
from
diverse
classes
Clostridia,
Bacilli,
Coriobacteriia,
with
capacity
hydrolyze
(di)fluorinated
organic
acids
fluorinated
amino
acid.
Whole-protein
alanine
scanning,
molecular
dynamics
simulations,
chimeric
protein
design
enabled
identification
disordered
C-terminal
segment
involved
defluorination
activity.
Domain
swapping
exclusively
C-terminus
conferred
activity
non-defluorinating
dehalogenase.
To
advance
our
understanding
structural
sequence
differences
between
defluorinating
dehalogenases,
trained
machine
learning
models
which
identified
termini
as
important
features.
Models
on
41-amino
acid
segments
C-termini
alone
predicted
83%
accuracy
(compared
95%
based
full-length
features).
This
work
relevant
therapeutic
interventions
environmental
health
by
uncovering
specificity-determining
signatures
biochemistry
microbiome.
Significance
Humans
have
introduced
bonds
into
manufactured
compounds,
leading
formation
toxic
byproducts.
While
ability
metabolize
drugs,
encoded
strong
chemical
bond
unknown.
Here
that
capable
cleaving
bonds.
developed
96-well
colorimetric
amenable
bacterial
culture-based
screening.
additionally
conducted
whole-protein
scanning
mutagenesis
flexible
loop
residues
were
predictive
defluorination.
Taken
context
regions
other
enzyme
families
perform
chemistry,
this
supports
using
convergent
features
predict
specificity.
