Fisheries & Aquatic Life,
Год журнала:
2024,
Номер
32(3), С. 128 - 136
Опубликована: Сен. 1, 2024
Abstract
This
review
paper
presents
fish
reproductive
toxicology
studies
with
a
specific
focus
on
endocrine-disrupting
chemicals
(EDCs)
present
in
the
aquatic
environment.
These
substances,
including
bisphenols,
heavy
metals,
pesticides,
phthalates,
and
polychlorinated
biphenyls
(PCBs),
act
as
hormone
mimics,
receptor
blockers,
or
enzyme
inhibitors
that
affect
hormonal
regulation
hypothalamic-pituitary-gonadal
(HPG)
axis.
In
this
review,
we
provide
an
overview
of
adverse
effects
these
pollutants
both
female
male
reproduction
(i.e.,
disruption
HPG
axis,
gametogenesis
disorders,
disturbed
embryogenesis,
etc.).
Even
at
low
concentrations,
EDCs
can
exhibit
toxicity
fishes.
They
functioning
certain
systems
within
hypothalamus
(Kiss/GPR54,
GnRH)
also
impact
luteinizing
(LH)
secretion
pituitary.
compounds
have
negative
impacts
gonads,
oocyte
maturation,
steroidogenesis,
gametes.
Early-life
exposure
to
substances
not
only
affects
embryonic
development,
resulting
increased
mortality
body
malformations,
but
induces
genetic
changes
newly
hatched
larvae.
All
observations
underscore
need
for
monitoring
environment
implementing
protective
measures
preserve
health
welfare
fishes
safeguard
water
ecosystems.
The Science of The Total Environment,
Год журнала:
2024,
Номер
933, С. 173154 - 173154
Опубликована: Май 10, 2024
Personal
Care
Products
(PCPs)
have
been
one
of
the
most
studied
chemicals
in
last
twenty
years
since
they
were
identified
as
pseudo-persistent
pollutants
by
European
Union
early
2000s.
The
accumulation
PCPs
aquatic
environment
and
their
effects
on
non-target
species
make
it
necessary
to
find
new,
less
harmful,
substances.
Polyethylene
glycol
(PEGs)
polyvinyl
alcohol
(PVAs)
are
two
polymers
that
increased
presence
composition
recent
years,
but
little
is
known
about
effect
species.
Through
embryotoxicity
tests
common
models
organisms
(Danio
rerio
Xenopus
laevis),
this
work
aims
increase
knowledge
PEGs
PVAs'
Animals
exposed
pollutant
for
96
h.
main
endpoint
(mortality,
hatching,
malformations,
heartbeat
rate)
was
recorded
every
24
significant
results
hatching
delay
Danio
both
chemicals,
malformations
(oedema,
body
changes
pigmentation
deformations
spine
tail)
D.
X.
laevis
change
rate
(decrease
or
animals
all
tested.
Toxics,
Год журнала:
2023,
Номер
11(6), С. 538 - 538
Опубликована: Июнь 16, 2023
Pesticides
are
an
important
tool
for
maintaining
and
improving
the
global
population's
standard
of
living.
However,
their
presence
in
water
resources
is
concerning
due
to
potential
consequences.
Twelve
samples
from
rivers,
dams/reservoirs,
treated
drinking
were
collected
Mangaung
Metropolitan
Municipality
South
Africa.
The
analysed
using
high-performance
liquid
chromatography
linked
a
QTRAP
hybrid
triple
quadrupole
ion
trap
mass
spectrometer.
ecological
human
health
risks
assessed
by
risk
quotient
assessment
methods,
respectively.
Herbicides,
such
as
atrazine,
metolachlor,
simazine
terbuthylazine,
sources.
average
concentrations
rivers
(1.82
mg/L),
dams/reservoirs
(0.12
(0.03
mg/L)
remarkable
among
all
four
herbicides
detected.
Simazine,
terbuthylazine
posed
high
both
acute
chronic
toxicity
Moreover,
only
contaminant
river
that
poses
medium
carcinogenic
adult.
It
can
be
concluded
level
herbicide
detected
sources
may
affect
aquatic
life
beings
negatively.
This
study
aid
development
pesticide
pollution
management
reduction
strategies
within
municipality.
Frontiers in Toxicology,
Год журнала:
2024,
Номер
6
Опубликована: Окт. 7, 2024
Parabens
are
the
most
prevalent
ingredients
in
cosmetics
and
personal
care
products
(PCPs).
They
colorless
tasteless
exhibit
good
stability
when
combined
with
other
components.
Because
of
these
unique
physicochemical
properties,
they
extensively
used
as
antimicrobial
antifungal
agents.
Their
release
into
aquatic
ecosystem
poses
potential
threats
to
organisms,
including
fish.
We
conducted
an
electronic
search
PubMed
(
http://www.ncbi.nlm.nih.gov/pubmed
)
using
term
parabens
fish
sorted
93
articles
consisting
methyl
paraben
(MTP),
ethyl
(ETP),
propyl
(PPP),
butyl
(BTP),
benzyl
(BNP)
several
species.
Furthermore,
we
confined
our
six
species
(common
carp,
Cyprinus
carpio
;
fathead
minnows,
Pimephales
promelas
Japanese
medaka,
Oryzias
latipes
rainbow
trout,
Oncorhynchus
mykiss
Nile
tilapia,
Oreochromis
niloticus
zebrafish,
Danio
rerio)
four
common
(MTP,
ETP,
PPP,
BTP)
48
for
review.
Our
indicates
that
among
all
fish,
zebrafish
was
studied
MTP
tested
Moreover,
depending
on
alkyl
chain
length
linearity,
long-chained
were
more
toxic
than
short
chains.
can
be
considered
endocrine
disruptors
(EDs),
targeting
estrogen-androgen-thyroid-steroidogenesis
(EATS)
pathways,
blocking
development
growth
gametes,
causing
intergenerational
toxicity
impact
viability
offspring/larvae.
Paraben
exposure
also
induce
behavioral
changes
nervous
system
disorders
Although
USEPA
EU
limit
use
pharmaceuticals,
their
prolonged
persistence
environment
may
pose
additional
health
risk
humans.
ACS Agricultural Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
This
study
aimed
to
develop
broad-specificity
antibodies
for
detecting
prochloraz
and
its
metabolites.
Initially,
three
haptens
were
designed
identified
through
computational
chemical
methods,
the
hapten
H2
was
optimal
candidate.
Using
H2-BSA
as
an
immunogen,
monoclonal
antibody
9C3
prepared
recognize
PCH
two
metabolites,
BTS44595
BTS44596.
The
recognition
mechanism
revealed
that
"2,4,6-trichlorophenyl"
moiety
of
targets
is
completely
encapsulated
in
binding
pocket
mAb
hydrophobic
forces
play
crucial
roles
binding.
Furthermore,
indirect
enzyme-linked
immunosorbent
assay
a
colloidal
gold
immunochromatographic
residues
grapes
river
water
samples
developed.
IC50
ic-ELISA
8.08–15.07
ng/mL,
with
recovery
rates
ranging
from
73.80%
to101.13%.
In
addition,
visual
detection
limit
GICA
250–500
values
98.04
126.29
ng/mL
CRs
67.2
78.02%.
accuracy
precision
both
immunoassays
validated
by
LC–MS/MS.
