Environmental Science and Pollution Research,
Год журнала:
2023,
Номер
30(57), С. 120366 - 120374
Опубликована: Ноя. 8, 2023
Phthalate
exposure
is
widespread
and
has
a
global
impact.
Growing
evidence
shows
that
mono-2-ethylhexyl
phthalate
(MEHP)
negative
impact
on
human
health.
However,
whether
MEHP
associated
with
mortality
other
adverse
outcomes
in
hemodialysis
patients
remains
unknown.
This
study
prospectively
enrolled
217
maintenance
from
June
30,
2021,
to
August
16,
2022.
Baseline
serum
MEHP,
di-2-ethylhexyl
(DEHP),
indoxyl
sulfate
(IS)
concentrations
were
measured.
Primary
endpoints
all-cause
or
composite
outcomes,
including
death
plus
hospitalization
due
cardiovascular
disease,
heart
failure,
stroke,
infection,
cancer.
Serum
positively
DEHP
but
not
patients.
Additionally,
significantly
independently
(adjusted
hazard
ratios
[HRs],
1.04
1.03
per
ng/mL,
95%
confidence
intervals
[CIs],
1.01-1.07
1.00-1.05;
p
=
0.016
0.015,
respectively).
We
found
cutoff
value
of
for
predicting
both
endpoints.
Patients
≥
41.8
ng/mL
had
much
higher
risks
HRs,
39.2
13;
CIs,
2.44-65.7
2.74-61.4;
0.011
0.001,
outcomes.
Hemodialysis
above
poorer
prognoses
regarding
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 17, 2024
Reproductive
system
diseases
pose
prominent
threats
to
human
physical
and
mental
well-being.
Besides
being
influenced
by
genetic
material
regulation
changes
in
lifestyle,
the
occurrence
of
these
is
closely
connected
exposure
harmful
substances
environment.
Endocrine
disrupting
chemicals
(EDCs),
characterized
hormone-like
effects,
have
a
wide
range
influences
on
reproductive
system.
EDCs
are
ubiquitous
natural
environment
present
industrial
everyday
products.
Currently,
thousands
been
reported
exhibit
endocrine
this
number
likely
increase
as
testing
for
potential
has
not
consistently
required,
obtaining
data
limited,
partly
due
long
latency
many
diseases.
The
ability
avoid
EDCs,
especially
those
artificially
synthesized
origin,
increasingly
challenging.
While
can
be
divided
into
persistent
non-persistent
depending
their
degree
degradation,
recent
uptick
research
studies
area,
we
chosen
focus
pertaining
detrimental
effects
health
several
that
widely
encountered
daily
life
over
past
six
years,
specifically
bisphenol
A
(BPA),
phthalates
(PAEs),
polychlorinated
biphenyls
(PCBs),
parabens,
pesticides,
heavy
metals,
so
on.
By
focusing
impact
hypothalamic-pituitary-gonadal
(HPG)
axis,
which
leads
development
diseases,
review
aims
provide
new
insights
molecular
mechanisms
EDCs’
damage
encourage
further
in-depth
clarify
potentially
EDC
through
various
other
mechanisms.
Ultimately,
it
offers
scientific
basis
enhance
risk
management,
an
endeavor
significant
societal
importance
safeguarding
health.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 993 - 993
Опубликована: Янв. 24, 2025
Telomeres
protect
chromosome
ends
from
damage,
but
they
shorten
with
each
cell
division
due
to
the
limitations
of
DNA
replication
and
are
further
affected
by
oxidative
stress.
This
shortening
is
a
key
feature
aging,
telomerase,
an
enzyme
that
extends
telomeres,
helps
mitigate
this
process.
Aging
also
associated
mitochondrial
dysfunction,
leading
increased
reactive
oxygen
species
(ROS)
exacerbate
cellular
damage
promote
apoptosis.
Elevated
ROS
levels
can
telomeres
oxidizing
guanine
disrupting
their
regulation.
Conversely,
telomere
impacts
function,
activation
telomerase
has
been
shown
reverse
decline.
A
critical
link
between
dysfunction
response,
which
activates
tumor
suppressor
protein
p53,
resulting
in
reduced
biogenesis
metabolic
disruptions.
highlights
bidirectional
relationship
maintenance
function.
review
explores
complex
interactions
mitochondria
across
various
types,
fibroblasts
sperm
cells,
shedding
light
on
interconnected
mechanisms
underlying
aging
Abstract
This
paper
investigates
the
complex
relationship
between
immune
system
and
male
reproductive
processes,
emphasizing
how
chronic
inflammation
can
adversely
affect
health.
The
plays
a
dual
role;
it
protects
regulates
organs
spermatogenesis
while
maintaining
health
through
privilege
in
testes
activities
of
various
cells
cytokines.
However,
when
persists
or
intensifies,
disrupt
this
balance,
leading
to
attacks
on
tissues
resulting
infertility.This
study
provides
detailed
analysis
impair
sperm
production,
quality,
secretion
gonadal
hormones
both
directly
indirectly.
It
also
delves
into
critical
roles
testicular
privilege,
cells,
cytokines
sustaining
examines
impacts
infections,
autoimmune
diseases,
environmental
factors
fertility.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
277, С. 116394 - 116394
Опубликована: Апрель 24, 2024
Mono-2-ethylhexyl
phthalic
acid
(MEHP)
is
the
most
toxic
metabolite
of
plasticizer
di-2-ethylhexyl
(DEHP),
and
studies
have
shown
that
MEHP
causes
serious
reproductive
effects.
However,
its
exact
mechanisms
action
remain
elusive.
In
this
study,
we
aimed
to
investigate
effects
preliminarily
explore
underlying
molecular
mechanisms.
We
found
TM3
cells
gradually
secreted
less
testosterone
intracellular
free
cholesterol
with
increasing
exposure.
exposure
inhibited
lipophagy
Sirt1/Foxo1/Rab7
signaling
pathway
in
cells,
causing
aberrant
accumulation
lipid
droplets.
Addition
Sirt1
agonist
SRT1720
Rab7
ML-098
alleviated
inhibition
increased
contents
cells.
inhibitory
effect
on
pathway,
whereas
only
protein
expression
by
had
no
Foxo1
expression.
This
suggests
inhibits
suppressing
ultimately
leading
a
further
decrease
cellular
secretion.
study
improves
our
current
understanding
toxicity
provides
new
insights
into
esters.
