AFB1 Toxicity in Human Food and Animal Feed Consumption: A Review of Experimental Treatments and Preventive Measures
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5305 - 5305
Опубликована: Май 13, 2024
The
current
review
aims
to
outline
and
summarize
the
latest
research
on
aflatoxin,
with
studies
describing
natural,
herbal
chemical
compound
applications
in
animal
(pig)
models
vitro
cellular
studies.
Aflatoxin,
a
carcinogenic
toxin
metabolite,
is
produced
by
Aspergillus
flavus
humid
environments,
posing
threat
human
health
crop
production.
treatment
involves
prevention
of
exposure
aflatoxin
counteracting
its
harmful
toxic
effects,
enabling
survival
an
antidote
for
aflatoxin.
To
prospects
influence
forage
farm
production,
food
processing.
application
remedies
treat
undergoing
development
pinpoint
biochemical
pathways
responsible
effects
transmission
actions
treatment.
underline
environmental
stress
meat
dairy
products;
describe
clinical
syndromes
associated
aflatoxicosis
that
are
counteracted
proposed
preventive
interventions.
understand
how
improve
animals
feed
conditions.
Язык: Английский
Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7221 - 7221
Опубликована: Июнь 29, 2024
Decades
of
research
have
identified
genetic
and
environmental
factors
involved
in
age-related
neurodegenerative
diseases
and,
to
a
lesser
extent,
neuropsychiatric
disorders.
Genomic
instability,
i.e.,
the
loss
genome
integrity,
is
common
feature
among
both
(mayo-trophic
lateral
sclerosis,
Parkinson's
disease,
Alzheimer's
disease)
psychiatric
(schizophrenia,
autism,
bipolar
depression)
instability
associated
with
accumulation
persistent
DNA
damage
activation
response
(DDR)
pathways,
as
well
pathologic
neuronal
cell
or
senescence.
Typically,
DDR
signaling
ensures
that
genomic
proteomic
homeostasis
are
maintained
dividing
cells,
including
neural
progenitors,
post-mitotic
neurons.
However,
dysregulation
these
protective
responses,
part
due
aging
insults,
contributes
progressive
development
and/or
In
this
Special
Issue,
we
introduce
highlight
overlap
between
disorders,
emerging
clinical,
genomic,
molecular
evidence
for
contributions
aberrant
repair.
Our
goal
illuminate
importance
subject
uncover
possible
treatment
prevention
strategies
relevant
devastating
brain
diseases.
Язык: Английский
Investigating the role of food pollutants in autism spectrum disorder: a comprehensive analysis of heavy metals, pesticides, and mycotoxins
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 28, 2024
Язык: Английский
The effect of DNA polymeraseon autism tasted by aflatoxin B1
Theoretical and Natural Science,
Год журнала:
2024,
Номер
44(1), С. 150 - 155
Опубликована: Июль 26, 2024
Purpose:
Since
aflatoxins
B1
can
cause
autism
in
mice
by
disrupting
DNA
repair
and
altering
the
stability
of
genome,
study
aims
to
see
whether
pol
alleviate
tasted
AFB1,
because
its
function.
Whats
more,
would
identify
gene
damage
be
repaired
polymerase
.
Methods:
In
this
study,
four
groups
BTBR
were
selected.
The
positive
group
was
normal
mice,
other
AFB1-infected
experimental
treated
with
,
negative
which
blank
vector.
RT-PCR
then
used
detect
changes
transcript
levels
as
an
indicator
could
treat
autism.
Possible
results:
There
are
three
main
possible
(1)
cure
completely.
(2)
partially.
(3)
has
no
therapeutic
effect
on
Conclusion:
results
will
provide
important
insights
into
treatment
It
increase
our
understanding
function
improve
peoples
human
health.
also
points
a
way
develop
clinical
treatments
for
people
aflatoxins.
Язык: Английский