Possible Genotoxic Effects of Post-Harvest Fungicides Applied on Citrus Peels: Imazalil, Pyrimethanil, Thiabendazole and Their Mixtures
Foods,
Год журнала:
2025,
Номер
14(7), С. 1264 - 1264
Опубликована: Апрель 3, 2025
Post-harvest
fungicides
are
frequently
used
on
citrus
peels
to
reduce
post-harvest
fungal
contamination
during
the
storage
and
transport
of
products.
Despite
these
positive
effects,
can
pose
health
risks
consumers.
The
aim
our
study
was
perform
a
genotoxicological
risk
assessment
imazalil,
pyrimethanil,
thiabendazole
their
mixtures
as
treatments.
A
Salmonella
mutagenicity
Ames
test
comet
assay
were
performed
detect
reverse
mutation
assess
DNA
damage.
Base-pair,
frameshift
mutations
metabolic
activity
analyzed
using
test.
In
assay,
lymphocytes
treated
with
for
4
24
h.
Thiabendazole
found
induce
both
base-pair
in
despite
imzalil
pyrimethanil
(p
<
0.05).
DNA-strand
breaks
observed
lymphocytes,
mainly
dimethyl-sulfoxide
solvent
long-term
exposure
consumption
fruits
vegetables
increase
developing
genotoxic
tumors.
Our
findings
raise
new
questions
about
Further
investigations
essential
explore
effects
peels.
Язык: Английский
DNA Damage in Fish Due to Pesticide Pollution
Natural and Engineering Sciences,
Год журнала:
2023,
Номер
8(3), С. 195 - 201
Опубликована: Дек. 14, 2023
Toxic
contaminants,
including
pesticides,
microplastics,
and
heavy
metals,
have
a
significant
impact
on
aquatic
life
other
species.
These
pollutants
come
from
anthropogenic
sources
such
as
crop
growing,
industrial
operations,
effluent,
residential
wastewater,
leaching,
well
environmental
events
like
storms,
floods,
seismic
processes.
Pesticides,
particularly
been
shown
to
detrimental
effects
ecology,
causing
decreased
growth,
restricted
larvae
embryo
development,
dysfunction
in
primary
organs
the
gill,
liver,
kidney,
gonad.
Genotoxicity
pesticide
exposure
raises
safety
concerns,
prolonged
can
lead
oxidative
stress,
mutagenicity,
cellular
apoptosis.
Pesticide
elevated
levels,
even
without
measurable
concentrations
biological
matrices.
The
toxicity
of
pesticides
directly
affects
life,
leading
high
mortality
rates
or
complete
elimination
species
that
serve
their
food
source.To
maintain
well-being
organisms,
fish,
protect
ecosystems,
it
is
crucial
investigate
safe,
acceptable,
efficient
alternatives
pesticides.
In
this
study,
we
focuses
hematological,
biochemical,
histopathological
changes
induced
by
highlights
strategies
for
mitigating
adverse
impacts
fish.
Further
investigation
needed
determine
suitability
detection,
an
essential
aspect
monitoring
environments
agricultural
Язык: Английский
Cancer Genetics in the Arab World
Technology in Cancer Research & Treatment,
Год журнала:
2025,
Номер
24
Опубликована: Апрель 1, 2025
Cancer
remains
a
major
global
health
burden,
with
incidence
rates
rising
globally.
The
Arab
world,
which
is
often
regarded
as
an
underrepresented
population
in
literature,
shows
distinct
patterns
cancer
incidences,
genetics,
and
outcomes
comparison
Western
populations.
This
review
aims
to
highlight
key
genomic
studies
conducted
the
world.
We
describe
epidemiological
genetic
landscape
of
populations,
focusing
on
lung,
breast,
colorectal
cancers,
given
their
prominence
distinctive
region.
utilised
data
from
GLOBOCAN
2022
published
assess
subregional
trends,
identify
significant
mutations,
explore
hereditary
early-onset
cancers
profiles.
Breast,
dominate
profile
region,
disparities
alterations
when
compared
trends.
Variation
EGFR
mutation
frequencies
lung
across
diverse
ethnicities
MENA
region
representative
extreme
heterogeneity
Variations
BRCA1/2
frequency,
unique
founder
mutations
breast
cancer's
particular
regional
traits.
Similarly,
show
variations
mutational
profiles,
such
low
BRAF
epigenetic
characteristics
that
represent
region-specific
disease
pathways.
Early-onset
particularly
occur
at
higher
than
populations
diverge
typical
germline
reported
emphasises
importance
conducting
localised
improving
personalised
medicine
public
strategies.
Despite
these
efforts,
gaps
remain,
understanding
disorders,
are
overrepresented
Further
research
basis
essential
for
advancing
treatment
under-researched
groups.
Язык: Английский
Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab Countries: A Systematic Review and Meta-Analysis
Toxics,
Год журнала:
2023,
Номер
11(8), С. 663 - 663
Опубликована: Авг. 1, 2023
Exposure
to
pesticides
in
Arab
countries
is
a
significant
public
health
concern
due
extensive
agricultural
activity
and
pesticide
use.
This
systematic
review
aimed
evaluate
the
genotoxic
effects
of
exposure
region,
identify
research
gaps,
assess
methodological
limitations.
Following
PRISMA
guidelines,
comprehensive
search
yielded
five
relevant
studies
conducted
Egypt,
Syria,
Jordan.
Various
genotoxicity
assays
were
employed,
revealing
higher
level
DNA
damage
exposed
compared
non-exposed
individuals.
Farmers
exhibited
significantly
occurrence
chromosomal
translocation
(t(14;18)),
micronuclei,
aberrations.
However,
only
two
assessed
cytotoxicity
indirectly.
The
predominantly
focused
on
male
participants,
with
variations
sample
size
types.
lack
detailed
data
necessitates
cautious
interpretation.
underscores
need
for
further
occupational
Middle
East.
Future
should
adopt
robust
study
designs,
collect
biological
environmental
samples,
conduct
repeated
sampling,
analyze
seasonal
variations,
encompass
diverse
sites
associated
specific
crop
groups.
Язык: Английский
Genotoxicity of Prenatal and Early Childhood Exposure to Pesticides: A Protocol and Pilot Study of a Systematic Review and Meta-Analysis
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 29, 2024
1.
Abstract
Objectives
To
systematically
review
and
meta-analyse
the
genotoxic
impact
of
prenatal
early
childhood
pesticide
exposure,
investigating
prevalence,
specific
pesticides,
effect
size,
mechanisms,
genetic
susceptibility,
vulnerable
periods.
Study
Design
A
protocol
for
systematic
meta-analysis.
pilot
study
was
also
conducted
to
develop
appropriate
extraction
risk
bias
tool.
Methods
Adhering
2020
PRISMA
guidelines,
will
explore
exposure
in
children
up
5
years.
The
had
been
registered
International
Prospective
Register
Systematic
Reviews
(PROSPERO)
database
(CRD42024510877).
Searches
done
across
PubMed,
EMBASE,
Web
Science,
Scopus
use
keywords
‘prenatal
or
childhood’,
‘pesticides’,
‘genotoxicity’.
Manual
reference
screening
supplements
searches.
Eligible
observational
studies
(cross-sectional,
case-control,
cohort
designs)
English
be
included,
while
excluding
case
reports
vitro
studies,
using
Covidence
Two
independent
reviewers
Newcastle-Ottawa
Scale
novel
tool
cross-sectional
screening,
data
extraction,
assessment.
Findings
synthesized
narratively,
with
potential
meta-analysis
genotoxicity
outcomes.
GRADE
approach
assess
evidence
quality.
Results
test
screened
1,405
resulting
21
eligible
full-text
screening.
Twelve
were
excluded.
Data
assessment
followed
pre-defined
protocols.
informed
refinement
procedures.
Conclusions
outlines
a
comprehensive
aiming
provide
necessary
insights
better
understanding
this
environmental
risk.
Язык: Английский
Immunotoxic Effects in Children Resulting from Prenatal and Early Childhood Exposure to Pesticides: Protocol of a Systematic Review and Meta-Analysis
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 6, 2024
Abstract
Background
Pesticides,
commonly
employed
in
both
agricultural
and
domestic
environments,
have
been
associated
with
disturbing
the
balance
of
immune
system
during
prenatal
early
childhood
phases
development.
This
disturbance
has
potential
to
result
various
outcomes
such
as
autoimmunity,
immunosuppression,
inflammation,
hypersensitivity,
tissue
damage,
overall
alterations
modulation.
The
escalating
concern
regarding
immunotoxic
effects
pesticides
necessitates
a
systematic
review
meta-analysis
consolidate
empirical
evidence
address
knowledge
gaps.
aims
comprehensively
assess
impact
pesticide
exposure
on
children,
considering
function
induced
by
specific
types
pesticides.
Methods
Through
meticulous
search
literature
synthesis
findings,
will
scrutinize
prevalence,
effect
size,
mechanisms,
vulnerable
periods,
role
pre-existing
conditions.
submitted
protocol
PROSPERO
aligns
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
Protocols
(PRISMA-P)
statement,
ensuring
methodological
rigor.
A
preliminary
exploration
involved
electronic
databases
based
pre-defined
Population,
Exposure,
Comparator,
Outcome
(PECO)
statement.
Data
extraction
sheets
risk
bias
assessment
tools
were
piloted
eight
eligible
articles
ensure
reliability
efficiency.
Subsequently,
rerun
be
executed,
two
independent
reviewers
employ
tool
Covidence
article
screening
data
extraction,
Excel
assessment.
results
synthetized
narratively
summary
tables,
and,
if
findings
allow,
including
subgroup
sensitivity
analysis
conducted.
Discussion
By
elucidating
intricate
relationship
between
immunotoxicity
childhood,
this
provide
insights
into
response
that
can
contribute
public
health
awareness
guide
interventions.
Registration
number
[CRD42024510916].
Impact
Statement
study
establish
high
level
highlight
critical
risks
exposure,
offering
essential
policies
interventions
safeguard
infants
developmental
periods.
Язык: Английский
Investigation of the Genotoxic Effects of the Analgesic Drugs Piroxicam and Tenoxicam in Human Lymphocytes
Black Sea Journal of Engineering and Science,
Год журнала:
2023,
Номер
6(4), С. 540 - 549
Опубликована: Сен. 29, 2023
Analgesics
are
one
of
the
most
widely
used
drug
groups
in
world.
Since
genotoxic
and
carcinogenic
effects
some
analgesic
drugs
have
been
detected,
studies
investigating
these
increased.
In
this
study,
Tenoxicam
Piroxicam
were
investigated
vitro
human
peripheral
lymphocytes
by
chromosomal
aberrations
(CAs)
micronucleus
(MN)
assays.
addition,
mitotic
index
(MI)
nuclear
division
(NDI)
values
also
determined.
As
a
result,
no
difference
abnormalities
was
observed
both
24
48
hours
treatment.
Micronucleus
frequency
increased
at
three
highest
concentrations
(0.94,
1.88
3.75
µg/mL)
compared
to
control.
significantly
decreased
MI
control
solvent
µg/mL
all
exposure
times.
showed
statistically
significant
increase
concentration
(10
μg/mL)
h
CA
On
other
hand,
effect
48-hour
It
concluded
that
tenoxicam
did
not
cause
toxic
any
except
MN
assay
results.
Mitotic
1.25,
2.5,
5
10
μg/mL.
Nuclear
results
change
for
agents.
conclusion,
agents
found
be
only
high
weak.
This
study
is
pioneering
as
there
previous
Tenoxicam.
These
need
supported
different
cell
vivo
Язык: Английский