Acta medica Eurasica,
Год журнала:
2024,
Номер
4, С. 36 - 45
Опубликована: Дек. 27, 2024
Radiation-induced
intestinal
damage
is
a
typical
complication
of
radiation
exposure,
it
can
be
caused
by
various
sources
radiation.
Clinical
treatment
today
consists
symptomatic
supportive
therapy,
as
there
are
no
specific
strategies.
The
main
target
the
epithelial
cells
mucous
membrane
small
intestine.
study
morphological
changes
and
mechanisms
to
necessary
when
developing
model
intestine
for
further
assessment
severity
pharmacological
correction.
purpose
work
provide
state
tissue
in
mouse
mucosa
on
9th
day
after
single
exposure
X-ray
at
absorbed
doses
(6.5,
7
7.8
Gy).
Materials
methods.
was
performed
sexually
mature
white
outbred
male
mice
weighing
18-22
g
(n
=
50).
Acute
sickness
simulated
using
RUM-17
therapy
unit.
animals
three
experimental
groups
15
each)
received
irradiation
with
different
6.5,
Gy,
respectively.
On
irradiation,
material
fixed
according
routine
technique
transmission
electron
microscopy.
analysis
semifine
sections
carried
out
Scope
A1c
light
microscope
an
Axiocam
ERc
5s
camera
ZEN
2.3
morphometric
program
processing
Microsoft
Office
Excel
2013.
Results.
When
exposed
jejunum
mice,
common
features
were
revealed:
decrease
height
deformation
villi;
enterocytes
from
32.03±2.21
µm
intact
22.86±0.51
(at
Gy);
crypts,
had
significant
changes;
dividing
located
along
entire
depth
crypts;
increase
length
microvilli
brush
border
apical
surface
0.89±0.01
1.46±0.03
Gy)
revealed.
Sublethal
lethal
characterized
slight
expansion
basal
parts
crypts
profiles
actively
synthesizing
goblet
cells,
dose
6.5
similar
more
pronounced.
In
all
groups,
loose
connective
proper
plate
abundantly
infiltrated
leukocytes.
Epithelial
cell
extrusion
zones
weakly
expressed
surfaces
villi.
A
sharp
number
Paneth
Conclusions.
reactive
have
non-specific
character.
most
pronounced
them
noted
Gy.
absorbing
results
disturbances
its
basic
function.
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Авг. 16, 2024
Ionizing
radiation
is
a
significant
risk
factor
for
cataracts,
but
the
pathogenesis
of
radiation-induced
cataracts
remains
incompletely
understood.
Ferroptosis,
an
iron-dependent
form
programmed
cell
death
discovered
in
recent
years,
has
gained
increasing
attention
its
role
various
diseases.
This
article
systematically
reviews
research
progress
on
ionizing
radiation,
ferroptosis,
age-related
and
cataracts.
It
proposes
“ferroptosis
hypothesis”
Through
ionization
oxidative
stress
effects,
leads
to
elevated
free
iron
levels
exacerbated
lipid
peroxidation
lens
cells,
activating
ferroptosis
pathway
resulting
opacity.
The
involvement
development
suggests
that
it
may
also
be
important
pathogenic
mechanism
Targeting
novel
strategy
preventing
treating
Furthermore,
developing
new
ferroptosis-specific
inhibitors
with
improved
targeting
pharmacokinetic
properties
essential
direction
study
provides
insights
into
management
potentially
transforming
from
“inevitable”
“preventable
treatable.”
International Journal of Radiation Biology,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Фев. 19, 2025
Purpose
The
development
of
radiation
countermeasures
is
an
unmet
need.
Several
cytoprotective
approaches
have
been
demonstrated
to
minimize
ionizing
radiation-induced
tissue
toxicity.
Previously,
our
research
indicated
that
mild
mitochondrial
uncoupling
by
2,4-dinitrophenol
(DNP)
potentially
counteract
the
IR-induced
cell
death.
Herein,
investigation
delves
into
radio-protective
efficacy
DNP
following
total-body
irradiation
(TBI)
in
C57BL/6
mice.
Molecular Nutrition & Food Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 17, 2025
ABSTRACT
The
gastrointestinal
tract
is
highly
sensitive
to
ionizing
radiation
(IR),
which
causes
radiation‐induced
intestinal
injury
(RIII).
There
are
no
effective
drugs
available
for
RIII
in
routine
clinical
treatment,
a
major
limiting
factor
during
the
process
of
radiotherapy
pelvic
abdominal
malignancies.
In
this
study,
we
aimed
elucidate
potential
probiotic
Bacillus
coagulans
BC99
(
B.coagulans
BC99)
preventing
RIII.
C57BL/6J
mice
were
gavage‐administered
with
30
days
and
then
exposed
single
dose
12
Gy
x‐ray
whole
irradiation
(WAI).
treatment
could
mitigate
by
weight
loss,
maintaining
integrity
structure
barrier,
improving
inflammatory
symptoms,
modulating
oxidative
stress,
regulating
composition
gut
microbiota,
thereby
reestablishing
homeostasis.
addition,
radioprotective
mechanism
was
closely
related
microbiota‐derived
metabolites.
This
study
offers
novel
perspective
advancing
probiotic‐based
treatments
enhancing
strategies
prevention
Pharmacology,
Год журнала:
2024,
Номер
unknown, С. 1 - 10
Опубликована: Авг. 20, 2024
Introduction:
Mast
cells
are
the
principal
involved
in
acute
and
chronic
colitis
due
to
radiation,
known
as
radiation-induced
(RIC).
In
this
study,
we
investigated
whether
pretreatment
with
tranilast,
a
mast
cell
inhibitor,
could
alleviate
RIC.
Methods:
A
total
of
23
Sprague-Dawley
rats
were
randomly
divided
into
three
groups:
control
group
(n
=
5),
radiation
(RG,
n
9),
tranilast-pretreated
(TG,
9).
The
RG
TG
irradiated
pelvic
area
(1.5
cm
from
anus)
single
dose
20
Gy
under
general
anesthesia.
Tranilast
(100
mg/kg)
was
administered
intraperitoneally
for
10
days,
starting
day
radiation.
Ten
weeks
after
euthanized.
Rectal
tissue
samples
histologically
evaluated
inflammation
score
(TIS)
count.
expression
MUC2,
MUC5AC,
matrix
metalloproteinase-9
(MMP-9)
also
assessed
immunohistochemically.
Results:
Both
TIS
specific
components
such
epithelial
atypia,
vascular
sclerosis,
cystica
profunda
(CCP)
significantly
higher
than
(p
0.02,
0.038,
0.025,
0.01,
respectively).
Thein
number
infiltrating
(median
[range]:
[3−54]
versus
6
[3−25],
respectively;
p
0.034).
Quantitatively,
MMP-9-positive
(23.67
±
19.00)
(10.25
8.45)
(mean
standard
deviation;
<
0.05).
MMP-9
exhibited
strong
association
(correlation
coefficient
r
0.56,
Immunohistochemically,
mucin-lake
CCP
showed
no
staining
MUC5AC
but
stained
positive
MUC2.
Conclusion:
RIC
an
anti-inflammatory
effect
associated
reduction
infiltration
expression.
Radiation effects and defects in solids,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Ноя. 5, 2024
Radiotherapy
plays
an
important
role
in
the
treatment
of
tumors,
and
enteritis
is
a
common
side
effect
this
therapy.
The
aim
present
study
was
to
evaluate
protective
melatonin
probiotics
on
radiation-induced
intestinal
tissue
damage
rats.
Histopathological,
biochemical
microbiological
samples
were
examined.
