Preliminary Study to Investigate Possible Cyto-Genotoxic and Oxidative Effects of Few-Layer Graphene in Human Bronchial Cells DOI Open Access

Anna Maria Fresegna,

Aureliano Ciervo,

Cinzia Lucia Ursini

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13515 - 13515

Опубликована: Дек. 17, 2024

Graphene and its various derivatives, known as graphene-based nanomaterials (GBNs), hold tremendous potential across many fields due to their exceptional properties. As with any novel material, concerns about safety have emerged alongside widespread production use. Several studies shown that GBNs can diverse effects on cell lines organisms under different exposure conditions. This study intends evaluate the toxicity of few-layer graphene (FLG) in human bronchial BEAS-2B. Cells were exposed concentrations FLG for 24 h, cyto-genotoxic, oxidative, inflammatory evaluated. We found an increase cytotoxicity terms death, apoptosis, membrane damage at highest concentration. also detected a slight direct DNA percentage comets. Oxidative was observed did not induce notable cytokine release. Overall, this suggests cytotoxicity, BEAS-2B, particularly high concentrations. These findings contribute better understanding health highlight importance considering dose-dependent when assessing GBNs.

Язык: Английский

Advancements in Cancer Treatment: Harnessing the Synergistic Potential of Graphene-Based Nanomaterials in Combination Therapy DOI
A. Keyvani,

Parizad Mohammadnejad,

Hamidreza Pazoki–Toroudi

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Combination therapy, which involves using multiple therapeutic modalities simultaneously or sequentially, has become a cornerstone of modern cancer treatment. Graphene-based nanomaterials (GBNs) have emerged as versatile platforms for drug delivery, gene and photothermal therapy. These materials enable synergistic approach, improving the efficacy treatments while reducing side effects. This review explores roles graphene, graphene oxide (GO), quantum dots (GQDs) in combination therapies highlights their potential to enhance immunotherapy targeted therapies. The large surface area high drug-loading capacity facilitate codelivery agents, promoting sustained release. GQDs, with unique optical properties, offer real-time imaging capabilities, adding another layer precision However, challenges such biocompatibility, long-term toxicity, scalability need be addressed ensure clinical safety. Preclinical studies show promising results GBNs, suggesting revolutionize treatment through innovative

Язык: Английский

Процитировано

2
Photodynamic bactericidal nanomaterials in food packaging: From principle to application DOI
Chushu Zhang, Jiancheng Zhang,

Shining Cao

и другие.

Journal of Food Science, Год журнала: 2025, Номер 90(1)

Опубликована: Янв. 1, 2025

Compared to traditional preservatives, photodynamic inactivation (PDI) offers a promising bactericidal approach due its nontoxic nature and low propensity for microbial resistance. In this paper, we initially investigate the principles antibacterial mechanisms underlying PDI. We then review factors influencing PDI's germicidal efficacy in food preservation. Furthermore, delve into application potential of PDI nanomaterials, such as quantum dots, titanium dioxide, graphene, packaging films. Special attention is given impact treatment on quality tolerance development. Last, discuss migration safety nanomaterials. The chemical basis involves generation reactive oxygen species through activation endogenous or exogenous photosensitizers. Its primary encompass disruption cell membranes, impairment cellular functions, inhibition quorum sensing. multi-target action significantly reduces likelihood resistance has great field packaging. information contained paper will provide effective reference design new

Язык: Английский

Процитировано

2
Eco-friendly optical sensor membrane for nickel ion detection in water and food samples DOI Creative Commons
Abdullah H. Alluhayb, Alaa M. Younis, Ahmad O. Babalghith

и другие.

Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102007 - 102007

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
The Influence of Nanoparticles of Graphene Oxide‑PEG on Cytokine Profile of Monocytes from Human Blood In Vitro DOI Open Access
D. I. Usanina, М. С. Бочкова, В. П. Тимганова

и другие.

Trends in Immunotherapy, Год журнала: 2025, Номер 9(1), С. 8 - 22

Опубликована: Янв. 17, 2025

This study investigated the response of human monocytes to co-culture with pegylated (linear or branched) graphene oxide (GO) nanoparticles, specifically examing both small (P-GOs, 100 -200 nm) and larger (P-GOb, 1-5 μm) particles at concentrations 5, 25, 50 µg mL–1. Human (CD14+ cells) were isolated cultured these nanoparticles for 72 hours. We measured cell viability, lactate dehydrogenase (LDH) release, cytokine production. The findings showed that P-GO had little effect on production, including MIF, GM-CSF, VEGF, IP-10, IL-8, HGF, SCGF-beta in vitro. At a low concentration (5 μg mL–1), exhibited minimal influence cytokines, except forthe LP-GOb variant, which increased M-CSF Conversely, 25 mL–1 enhanced release variouscytokines, proinflammatory IL-6, IL-1β, IL-1α, IL-18, IL-17, IL-16, IFN-γ, TNF-β, TNF-α, anti-inflammatory IL-1ra, IL-13, IL-10, IL-4, regulatory G-CSF, IL-2, IL-3, IL-5, IL-12 (p40), (p70), M-CSF, GM-CSF chemokines CTACK, Eotaxin, GRO-α, RANTES, MIP-1β, MCP-1, MIP-1α, MCP-3, MIG, SDF-1α, growth factors Basic FGF, PDGF-BB, SCF, LIF TRAIL. Although higher resulted significant monocyte viability remained largely unaffected . LDH was elevated solely samples treated LP-GOb. BP-GOs profiles, raising levels highest concentration. These results indicate modifying may hold potential creating graphene-based pharmacological agents.

Язык: Английский

Процитировано

0
The Role and Future of Functional Graphenic Materials in Biomedical and Human Health Applications DOI Creative Commons
Anne M. Arnold, Juhi Singh, Stefanie A. Sydlik

и другие.

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Functional graphenic materials (FGMs) are derived from graphene oxide (GO) that hold a plethora of applications electronics to nanomedicine. In this Perspective, we examine the history and evolution biomedical carbon-based macromolecule. Following carbon nanotube (CNT) movement, GO FGMs became nanocarbons interest because their low cost versatile functionality. The tunable chemistry enabled our work on coupled with biomacromolecules allows plays an important role in many applications, tissue regeneration controlled delivery. As develop material, it is critical consider toxicity implications─in fresh as well degradation products. With understanding, also potential roles human health environmental sustainability, making contemporary biomacromolecule.

Язык: Английский

Процитировано

0
Scaling up the graphene production from R&D to the pilot plant stage: Implications for workers' exposure to airborne nano-objects DOI

Claudio Natale,

Francesca Tombolini,

Riccardo Ferrante

и другие.

NanoImpact, Год журнала: 2025, Номер unknown, С. 100555 - 100555

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Nanotheranostics Revolutionizing Gene Therapy: Emerging Applications in Gene Delivery Enhancement DOI Creative Commons
Paula Guzmán-Sastoque, Cristian F. Rodríguez,

María Camila Monsalve

и другие.

Journal of Nanotheranostics, Год журнала: 2025, Номер 6(2), С. 10 - 10

Опубликована: Апрель 9, 2025

Nanotheranostics—where nanoscale materials serve both diagnostic and therapeutic functions—are rapidly transforming gene therapy by tackling critical delivery challenges. This review explores the design engineering of various nanoparticle systems (lipid-based, polymeric, inorganic, hybrid) to enhance stability, targeting, endosomal escape genetic payloads. We discuss how real-time imaging capabilities integrated into these platforms enable precise localization controlled release genes, improving treatment efficacy while reducing off-target effects. Key strategies overcome barriers (such as proton sponge effect photothermal disruption) achieve nuclear are highlighted, along with recent advances in stimuli-responsive that facilitate spatiotemporal control expression. Clinical trials preclinical studies demonstrate expanding role nanotheranostics managing cancer, inherited disorders, cardiovascular neurological diseases. further address regulatory manufacturing hurdles must be for widespread clinical adoption nanoparticle-based therapies. By synthesizing progress ongoing challenges, this underscores transformative potential effective, targeted, image-guided delivery.

Язык: Английский

Процитировано

0
Advancing gut microbiome insights: Graphene quantum dot nanobiosensors for microbial metabolite detection DOI
Soheil Sadr, Shakiba Nazemian, Shiva Dianaty

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162954 - 162954

Опубликована: Апрель 1, 2025

Процитировано

0
Comparison of developmental toxicity of graphene oxide and graphdiyne to zebrafish larvae DOI

Wanyan Wu,

Weichao Zhao, Chaobo Huang

и другие.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2024, Номер 281, С. 109924 - 109924

Опубликована: Апрель 13, 2024

Язык: Английский

Процитировано

3
Structure-properties correlation of acrylic resins modified with silver vanadate and graphene DOI Creative Commons
Beatriz Danieletto Sahm, Izabela Ferreira,

João Marcos Carvalho‐Silva

и другие.

Heliyon, Год журнала: 2024, Номер 10(11), С. e32029 - e32029

Опубликована: Май 28, 2024

This study aimed to incorporate β-AgVO3 and rGO into self-curing (SC) heat-curing (HC) acrylic resins evaluate their physicochemical, mechanical, antimicrobial properties while correlating them with the characterized material structure. Acrylic resin samples were prepared at 0% (control), 0.5%, 1%, 3% for both nanoparticles. The microstructural characterization was assessed by scanning electron microscopy (SEM) (n=1) energy dispersive X-ray spectroscopy (EDS) (n=1). physicochemical mechanical tests included flexural strength (n=10), Knoop hardness roughness wettability sorption solubility porosity color evaluation (n=10). microbiological performed counting colony-forming units (CFU/mL) cell viability (n=8). results showed that lower counts of Candida albicans, Pseudomonas aeruginosa, Streptococcus mutans due promising properties. maintained addition β-AgVO3. higher microorganisms increase in It can be concluded incorporation could an alternative improve efficacy performance material.

Язык: Английский

Процитировано

3