Neurotoxicity of Some Environmental Pollutants to Zebrafish

Life, Год журнала: 2024, Номер 14(5), С. 640 - 640

Опубликована: Май 17, 2024

The aquatic environment encompasses a wide variety of pollutants, from plastics to drug residues, pesticides, food compounds, and other by-products, improper disposal waste is the main cause accumulation toxic substances in water. Monitoring, assessing, attempting control effects contaminants are necessary essential protect thus human animal health, study ecotoxicology has become topical. In this respect, zebrafish used as model organisms bioaccumulation, toxicity, influence environmental pollutants due their structural, functional, material advantages. There many similarities between metabolism physiological structures humans, nervous system structure, blood–brain barrier function, social behavior characteristics that make them an ideal for studying neurotoxicity. aim was highlight neurotoxicity nanoplastics, microplastics, fipronil, deltamethrin, rotenone behavioral, histological, oxidative status changes produced exposed them.

Язык: Английский

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The histopathological and functional consequences of microplastic exposure

Deleted Journal, Год журнала: 2025, Номер 7(1)

Опубликована: Янв. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Язык: Английский

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Microplastics in aquatic ecosystems: Detection, source tracing, and sustainable management strategies

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117883 - 117883

Опубликована: Фев. 1, 2025

Microplastics (MPs) are emerging contaminants characterized by persistence, cross-media transport, and complex pollutant interactions, posing serious ecotoxicological risks to ecosystems human health. Effective MPs management requires multi-faced, long-term, strategies involving targeted sampling, quantitative detection, comprehensive risk assessments, all of which entail significant resource investment. Despite advancements in remediation technologies, a holistic governance framework integrating these innovations remains underdeveloped. This review synthesizes current knowledge on MPs, elaborating their diverse morphologies, degradation pathways, role as vectors for toxic substances. State-of-the-art extraction techniques evaluated this article, including micropore adsorption using nanocomposites, alongside the incorporation advanced analytical tools such spectroscopic methods, electron microscopy, bioinformatics augment environmental forensics. also underscores necessity formulating robust global policies regulate pollution discusses potential biodegradation thermal sustainable solutions removal. By promoting an interdisciplinary approach, advocates coordinated response, science, policy frameworks, waste mitigate escalating impact well-being.

Язык: Английский

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Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics

Environment International, Год журнала: 2024, Номер 192, С. 109012 - 109012

Опубликована: Сен. 17, 2024

Язык: Английский

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Weathered polyethylene microplastics induced immunomodulation in zebrafish

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 109, С. 104478 - 104478

Опубликована: Май 25, 2024

Язык: Английский

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Mechanisms of eco-corona effects on micro(nano)plastics in marine medaka: Insights into translocation, immunity, and energy metabolism

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136236 - 136236

Опубликована: Окт. 21, 2024

Язык: Английский

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Utilizing zebrafish models to elucidate mechanisms and develop therapies for skeletal muscle atrophy

Life Sciences, Год журнала: 2025, Номер unknown, С. 123357 - 123357

Опубликована: Янв. 1, 2025

Язык: Английский

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Investigating the behavioral implications of microplastic exposure in animal species

Annals of Animal Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Abstract Microplastics (MPs) are pervasive pollutants impacting ecosystems worldwide, causing physical harm and behavioral changes in wildlife. MP toxicity mainly depends on size, porosity, weathering, surrounding compounds. MPs disrupt feeding metabolism, resulting reproductive, neurological, disorders. These impacts significantly alter ecological niches reduce animal survival. Understanding these is crucial for assessing the broader effects of plastic pollution developing effective mitigation strategies. This review investigated 110 papers quantifying consequences while considering their_physiological basis, emphasizing significance their potential long-term influence populations ecosystems. study thoroughly investigates model species, including plankton, fish, amphibians, crustaceans, pollinators, mammals. Fish exhibited most significant impact, crustaceans showed least. Mice, representing mammals, displayed severe physiological damage.

Язык: Английский

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Developing a feasible fast-track testing method for developmental neurotoxicity studies: alternative model for risk assessment of micro- and nanoplastics

Frontiers in Toxicology, Год журнала: 2025, Номер 7

Опубликована: Апрель 15, 2025

Micro- and nanoplastics (MNPs) are widespread environmental pollutants that pose significant health risks. They originate from industrial processes, consumer products, degradation, inducing oxidative stress through cellular dysfunctions such as membrane interaction, internalization, mitochondrial damage, inflammation, metal ion leaching, impaired antioxidant defense. Despite increasing evidence of their toxicity—particularly developmental neurotoxicity (DNT) impairment—our understanding remains limited due to the high costs animal studies, which reduce overall size experimental data. This underscores urgent need for alternative test methods cost-effective, rapid, translational. review examines new approach methodologies (NAMs) DNT assessment, addressing ethical, financial, translational limitations models. NAMs integrate three complementary non-animal models enhance conventional testing. First, zebrafish provide organismal insights into behavioral neurodevelopmental outcomes at minimal cost. Second, neuronal organoids replicate human-specific processes in a 3D system, offering mechanistic insights. Lastly, human cell lines enable high-throughput screening, integrating findings organoid studies. Establishing paradigm testing is crucial faster more efficient toxicity risk assessments, ultimately protecting public health. Standardizing gaining regulatory acceptance will improve predictive accuracy broaden application toxicology. Advancing these essential risks MNP exposure while promoting ethical sustainable research practices.

Язык: Английский

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Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity

Toxics, Год журнала: 2024, Номер 12(8), С. 617 - 617

Опубликована: Авг. 21, 2024

Nanoplastics, as emerging environmental pollutants, can transport contaminants across marine environments, polluting pristine ecosystems and being ingested by organisms. This transfer poses a severe threat to global aquatic potentially impacts human health through the food chain. Neurobehavioral reproductive toxicity are critical areas of concern because they directly affect survival, health, population dynamics species, which have cascading effects on entire ecosystem. Using zebrafish model organism, we investigated toxic concentrations polystyrene nanoplastics (PS-NPs). Behavioral assessments, including novel tank test open field test, demonstrated significant neurobehavioral changes, indicating increased anxiety depressive behaviors. A pathological analysis brain gonadal tissues, along with evaluations biomarkers, revealed that exposure PS-NPs leads tissue lesions, inflammatory responses, oxidative stress activation, hormone level disruptions, damage. Real-time quantitative PCR studies gene expression further showed disrupt endocrine regulation pathways brain-pituitary-gonadal (BPG) axis, causing sex-specific differences. These findings provide crucial insights into organisms their ecological risks, offering theoretical support for future protection pollutant management efforts.

Язык: Английский

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