Associations of exposure to volatile organic compounds with sleep health and potential mediators: analysis of NHANES data
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Июль 15, 2024
Objective
The
effect
of
environmental
pollution
on
sleep
has
been
widely
studied,
yet
the
relationship
between
exposure
to
volatile
organic
compounds
(VOCs)
and
health
requires
further
exploration.
We
aimed
investigate
single
mixed
urinary
VOC
metabolites
identify
potential
mediators.
Methods
Data
for
this
cross-sectional
study
was
collected
from
National
Health
Nutrition
Examination
Surveys
(NHANES)
(2005–2006,
2011–2014).
A
weighted
multivariate
logistic
regression
established
explore
associations
16
VOCs
with
four
outcomes.
Following
selection
important
through
least
absolute
shrinkage
operator
(LASSO)
regression,
principal
component
analyses
(PCA),
weight
quantile
sum
(WQS),
Bayesian
kernel
machine
(BKMR)
were
conducted
outcomes,
as
well
most
contributing
components.
mediation
analysis
performed
depression
scores.
Results
Of
3,473
participants
included
in
study,
a
total
618
diagnosed
poor
patterns.
In
analyses,
7,
10,
1,
5
significantly
positively
correlated
patterns,
abnormal
duration,
trouble
sleeping,
disorders,
respectively.
PCA
showed
that
PC1
substantially
linked
higher
risk
patterns
its
WQS
model
revealed
positive
association
mixture
increased
concentrations
[OR
(95%
CI):
1.285
(1.107,
1.493)],
duration
1.154
(1.030,
1.295)],
sleeping
1.236
(1.090,
1.403)]
disorders
1.378
(1.118,
1.705)].
BKMR
found
overall
disorders.
PCA,
WQS,
models
all
confirmed
significant
role
N
-acetyl-
S
-(
-methylcarbamoyl)-
l
-cysteine
(AMCC)
score
mediator
index
Conclusion
Exposure
negatively
affected
American
population,
AMCC
playing
role.
shown
mediate
mixtures
Язык: Английский
Possible implication of exposure to VOCs with the development of osteoporosis in the North American population according to NHANES
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
296, С. 118180 - 118180
Опубликована: Апрель 11, 2025
Язык: Английский
Impact of Polyfluoroalkyl Chemicals and Volatile Organic Compounds Exposure on Lung Function of American Adults
Environmental Pollution,
Год журнала:
2024,
Номер
unknown, С. 125152 - 125152
Опубликована: Окт. 1, 2024
Язык: Английский
Association Between Volatile Organic Compounds and Circadian Syndrome Among Pre- and Postmenopausal Women
Toxics,
Год журнала:
2025,
Номер
13(5), С. 328 - 328
Опубликована: Апрель 23, 2025
Air
pollution
is
closely
associated
with
the
development
of
multiple
metabolic
diseases.
Circadian
syndrome
(CircS),
as
an
extended
concept
(MetS),
has
been
proven
to
be
a
better
predictor
diseases
than
MetS.
However,
relationship
between
volatile
organic
compounds
(VOCs)
and
CircS
in
pre-
postmenopausal
women
remains
unclear.
This
study
used
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2011-2020,
including
520
premenopausal
531
women.
Generalized
linear
model
(GLM),
restricted
cubic
spline
(RCS)
model,
subgroup
analyses,
weighted
quantile
sum
(WQS)
were
assess
VOCs
CircS.
In
addition,
sensitivity
analyses
performed
evaluate
robustness
results.
Our
findings
showed
that
seven
VOC
metabolites
positively
risk
women,
only
two
The
WQS
analysis
further
confirmed
mixtures
selected
by
least
absolute
shrinkage
selection
operator
(LASSO)
significantly
increased
HPMMA
identified
primary
contributor
combined
effect.
association
was
not
evident
Meanwhile,
individual
urinary
observed
elevated
glucose
short
sleep.
results
highlighted
exposure
strongly
occurrence
Further
research
needed
confirm
this
conclusion.
Язык: Английский