The Combined Effects of Per- and Polyfluoroalkyl Substances, Metals, and Behavioral and Social Factors on Depressive Symptoms DOI Creative Commons

Olamide Ogundare,

Emmanuel Obeng-Gyasi

Medical Sciences, Год журнала: 2025, Номер 13(2), С. 69 - 69

Опубликована: Июнь 1, 2025

Background: This study investigates the combined effects of PFAS metals (PFOA and PFOS), heavy (lead, cadmium, mercury), behavioral factors (smoking alcohol consumption), social (income education) on depressive symptoms. Methods: Using cross-sectional data from National Health Nutrition Examination Survey (NHANES 2017–2018), blood samples were analyzed to determine exposure levels PFOA, PFOS, lead, mercury, self-reported evaluated in relation PHQ-9 scores among 181 adults. Results: Education was associated with lower odds symptoms (OR = 0.68, 95% CI: 0.43–1.07). Although result not statistically significant, estimate suggested a potential protective effect that warranted further investigation. Bayesian Kernel Machine Regression demonstrated collectively had strongest evidence for influencing depression (group PIP 0.6508), followed by socioeconomic 0.642). Bivariate exposure–response analyses revealed complex interaction patterns whereby varied substantially depending co-exposure contexts. Conclusions: These findings highlight are shaped interplays between environmental contaminants, behavior, determinants, underscoring importance mixture-based approaches mental health research need integrated interventions addressing both factors.

Язык: Английский

Per- and Polyfluoroalkyl Substances (PFAS) in Consumer Products: An Overview of the Occurrence, Migration, and Exposure Assessment DOI Creative Commons
Yang Yang, Jin Wang,

Shali Tang

и другие.

Molecules, Год журнала: 2025, Номер 30(5), С. 994 - 994

Опубликована: Фев. 21, 2025

Per- and polyfluoroalkyl substances (PFASs) have been widely used in the production of consumer products globally due to excellent water oil resistance anti-fouling properties. The multiple toxic effects some PFASs also pose a threat human health ecosystem, frequent use certain increased risk exposure PFASs. More data on occurrence, concentration, migration is urgently needed address possible risks posed by products. This paper reviews PFAS concentrations found, characteristics known, arising from several types over last five years. considered here include food contact materials, textiles, disposable personal hygiene influence different factors process these are summarized discussed. Additionally, main approaches models assessment evaluated summarized. Current challenges future research prospects this field discussed with view providing guidance for regulation

Язык: Английский

Процитировано

3
The Combined Effects of Per- and Polyfluoroalkyl Substances, Metals, and Behavioral and Social Factors on Depressive Symptoms DOI Creative Commons

Olamide Ogundare,

Emmanuel Obeng-Gyasi

Medical Sciences, Год журнала: 2025, Номер 13(2), С. 69 - 69

Опубликована: Июнь 1, 2025

Background: This study investigates the combined effects of PFAS metals (PFOA and PFOS), heavy (lead, cadmium, mercury), behavioral factors (smoking alcohol consumption), social (income education) on depressive symptoms. Methods: Using cross-sectional data from National Health Nutrition Examination Survey (NHANES 2017–2018), blood samples were analyzed to determine exposure levels PFOA, PFOS, lead, mercury, self-reported evaluated in relation PHQ-9 scores among 181 adults. Results: Education was associated with lower odds symptoms (OR = 0.68, 95% CI: 0.43–1.07). Although result not statistically significant, estimate suggested a potential protective effect that warranted further investigation. Bayesian Kernel Machine Regression demonstrated collectively had strongest evidence for influencing depression (group PIP 0.6508), followed by socioeconomic 0.642). Bivariate exposure–response analyses revealed complex interaction patterns whereby varied substantially depending co-exposure contexts. Conclusions: These findings highlight are shaped interplays between environmental contaminants, behavior, determinants, underscoring importance mixture-based approaches mental health research need integrated interventions addressing both factors.

Язык: Английский

Процитировано

0