The
production
and
application
of
nanomaterials
have
grown
tremendously
during
last
few
decades.
widespread
exposure
nanoparticles
to
the
public
is
provoking
great
concerns
regarding
their
toxicity
human
body.
However,
in
comparison
with
extensive
studies
carried
out
examine
nanoparticle
body/organs,
one
especially
vulnerable
organ,
eye,
always
neglected.
Although
it
a
small
part
body,
90%
outside
information
obtained
via
ocular
system.
In
addition,
eyes
usually
directly
interact
surrounding
environment,
which
may
get
severer
damage
from
toxic
compared
inner
organs.
Therefore,
study
assessing
potential
importance.
Here,
recent
advance
some
representative
manufactured
on
summarized.
First,
brief
introduction
anatomy
disorders
related
particulate
matter
presented.
Following,
factors
that
influence
eye
are
emphasized.
Next,
summarized
classified.
Finally,
limitations
associated
current
nanoparticle-eye
research
proposed.
Drug Delivery,
Год журнала:
2020,
Номер
27(1), С. 431 - 448
Опубликована: Янв. 1, 2020
Fibroin
is
a
dominant
silk
protein
that
possesses
ideal
properties
as
biomaterial
for
drug
delivery.
Recently,
the
development
of
fibroin
nanoparticles
(FNPs)
various
biomedical
applications
has
been
extensively
studied.
Due
to
their
versatility
and
chemical
modifiability,
FNPs
can
encapsulate
different
types
therapeutic
compounds,
including
small
big
molecules,
proteins,
enzymes,
vaccines,
genetic
materials.
Moreover,
are
able
be
administered
both
parenterally
non-parenterally.
This
review
summaries
basic
information
on
origin
characteristics,
followed
by
up-to-date
data
preparation
characterization
methods.
In
addition,
medical
delivery
system
in-depth
explored
based
several
administrative
routes
parenteral,
oral,
transdermal,
ocular,
orthopedic,
respiratory.
Finally,
challenges
suggested
solutions,
well
future
outlooks
these
systems
discussed.
The
production
and
application
of
nanomaterials
have
grown
tremendously
during
last
few
decades.
widespread
exposure
nanoparticles
to
the
public
is
provoking
great
concerns
regarding
their
toxicity
human
body.
However,
in
comparison
with
extensive
studies
carried
out
examine
nanoparticle
body/organs,
one
especially
vulnerable
organ,
eye,
always
neglected.
Although
it
a
small
part
body,
90%
outside
information
obtained
via
ocular
system.
In
addition,
eyes
usually
directly
interact
surrounding
environment,
which
may
get
severer
damage
from
toxic
compared
inner
organs.
Therefore,
study
assessing
potential
importance.
Here,
recent
advance
some
representative
manufactured
on
summarized.
First,
brief
introduction
anatomy
disorders
related
particulate
matter
presented.
Following,
factors
that
influence
eye
are
emphasized.
Next,
summarized
classified.
Finally,
limitations
associated
current
nanoparticle-eye
research
proposed.
