Preeclampsia and COVID-19: results from the INTERCOVID prospective longitudinal study

American Journal of Obstetrics and Gynecology, Год журнала: 2021, Номер 225(3), С. 289.e1 - 289.e17

Опубликована: Июнь 26, 2021

Язык: Английский

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CORONAVIRUS DISEASE 2019 (COVID-19): A LITERATURE REVIEW

Gevher Nesibe Journal IESDR, Год журнала: 2021, Номер 6(12), С. 56 - 72

Опубликована: Май 25, 2021

In early December 2019, an outbreak of coronavirus 2019 (COVID-19) caused by a novel severe acute respiratory syndrome 2 (SARS-CoV-2) occurred in Wuhan, China's Hubei province. On 30 January 2020, the World Health Organization and International Public declared emergency, as 23.03.2021, laboratory-approved 123,097,155 cases 2,716,151 deaths were reported worldwide. The perceived risk disease has led many countries to adopt various control measures. Emerging genetic clinical evidence suggests pathway similar SARS MERS. Potential therapeutic strategies that are currently being evaluated derive mainly from previous experience with Covid-19 treatment. Although several potential treatments for COVID-19 MERS have been identified animal vitro models, human trials still lacking, which hinders progress This review requires overview three major deadly coronaviruses assessment factors applicable lessons stop their spread leveraging learned first two outbreaks identifying areas improvement future preparedness plans. persistence can help inform public health officials medical practitioners efforts combat its progress. Also, this review, pathogenesis, epidemiology, diagnosis, treatment, vaccine reviewed.

Язык: Английский

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Long-Lasting Cognitive Abnormalities after COVID-19

Brain Sciences, Год журнала: 2021, Номер 11(2), С. 235 - 235

Опубликована: Фев. 13, 2021

Considering the mechanisms capable of causing brain alterations in COVID-19, we aimed to study occurrence cognitive abnormalities months following hospital discharge. We recruited 38 (aged 22–74 years; 27 males) patients hospitalized for complications SARS-CoV-2 infection nonintensive COVID units. Participants underwent neuropsychological testing about 5 after Of all patients, 42.1% had processing speed deficits, while 26.3% showed delayed verbal recall deficits. Twenty-one percent presented with deficits both and memory. Bivariate analysis revealed a positive correlation between lowest arterial oxygen partial pressure (PaO2) fractional inspired (FiO2) (P/F) ratio during hospitalization memory consolidation performance (SRT-LTS score, r = 0.404, p 0.027), as well SpO2 levels upon arrival (SRT-D rs 0.373, 0.042). Acute respiratory distress syndrome (ARDS) was associated worse (ARDS vs. no ARDS: SRT-LTS mean score 30.63 ± 13.33 44.50 13.16, 0.007; SRT-D 5.95 2.56 8.10 2.62, 0.029). Cognitive can frequently be found COVID-19 Increased fatigability, concentration memory, overall decreased discharge interfere work daily activities.

Язык: Английский

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Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases

Cardiovascular Research, Год журнала: 2022, Номер 119(2), С. 336 - 356

Опубликована: Июль 25, 2022

Abstract Long COVID has become a world-wide, non-communicable epidemic, caused by long-lasting multiorgan symptoms that endure for weeks or months after SARS-CoV-2 infection already subsided. This scientific document aims to provide insight into the possible causes and therapeutic options available cardiovascular manifestations of long COVID. In addition chronic fatigue, which is common symptom COVID, patients may present with chest pain, ECG abnormalities, postural orthostatic tachycardia, newly developed supraventricular ventricular arrhythmias. Imaging heart vessels provided evidence chronic, post-infectious perimyocarditis consequent left right failure, arterial wall inflammation, microthrombosis in certain patient populations. Better understanding underlying cellular molecular mechanisms will aid development effective treatment strategies its manifestations. A number have been proposed, including those involving direct effects on myocardium, microthrombotic damage endothelium, persistent inflammation. Unfortunately, existing circulating biomarkers, coagulation, inflammatory markers, are not highly predictive either presence outcome when measured 3 infection. Further studies needed understand mechanisms, identify specific guide future preventive treatments address sequelae.

Язык: Английский

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Severe Acute Respiratory Syndrome Coronavirus 2 Viremia Is Associated With Coronavirus Disease 2019 Severity and Predicts Clinical Outcomes

Clinical Infectious Diseases, Год журнала: 2021, Номер 74(9), С. 1525 - 1533

Опубликована: Авг. 9, 2021

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA (vRNA) is detected in the bloodstream of some patients with disease 2019 (COVID-19), but it not clear whether this RNAemia reflects viremia (ie, virus particles) and how relates to host immune responses outcomes. Methods SARS-CoV-2 vRNA was quantified plasma samples from observational cohorts 51 COVID-19 including 9 outpatients, 19 hospitalized (non–intensive care unit [ICU]), 23 ICU patients. levels were compared cross-sectional indices severity prospective clinical We used multiple imaging methods visualize virions plasma. Results 100%, 52.6%, 11.1% ICU, non-ICU, respectively. Virions pellets using electron tomography immunostaining. Plasma significantly higher > non-ICU outpatients (P < .0001); for inpatients, strongly associated World Health Organization (WHO) score at admission = .01), maximum WHO .002), discharge disposition .004). A level >6000 copies/mL mortality (hazard ratio, 10.7). Levels several inflammatory biomarkers .01) neutralizing antibody titers .8). Conclusions Visualization particles indicates that due, least part, viremia. The correlate severity, patient outcome, specific titers.

Язык: Английский

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Endothelial cells are not productively infected by SARS‐CoV‐2

Clinical & Translational Immunology, Год журнала: 2021, Номер 10(10)

Опубликована: Янв. 1, 2021

Thrombotic and microvascular complications are frequently seen in deceased COVID-19 patients. However, whether this is caused by direct viral infection of the endothelium or inflammation-induced endothelial activation remains highly contentious.Here, we use patient autopsy samples, primary human cells an vitro model pulmonary epithelial-endothelial cell barrier.We show that express very low levels SARS-CoV-2 receptor ACE2 protease TMPRSS2, which blocks their capacity for productive infection, limits to produce infectious virus. Accordingly, can only be infected when they overexpress ACE2, exposed high concentrations SARS-CoV-2. We also does not infect 3D vessels under flow conditions. further demonstrate a co-culture with Endothelial do however sense respond adjacent epithelial cells, increasing ICAM-1 expression releasing pro-inflammatory cytokines.Taken together, these data suggest vivo, unlikely may occur if epithelium denuded (basolateral infection) load present blood (apical infection). In such scenario, whilst occur, it contribute amplification. still play key role pathogenesis sensing mounting response

Язык: Английский

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Vasculopathy in COVID-19

Blood, Год журнала: 2022, Номер 140(3), С. 222 - 235

Опубликована: Янв. 5, 2022

Язык: Английский

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“Mask up to keep it up”: Preliminary evidence of the association between erectile dysfunction and COVID‐19

Andrology, Год журнала: 2021, Номер 9(4), С. 1053 - 1059

Опубликована: Март 20, 2021

Abstract Background Erectile dysfunction (ED), as the hallmark of endothelial dysfunction, could be a short‐ or long‐term complication COVID‐19. Additionally, being ED clinical marker and predictor non‐communicable chronic diseases, particularly cardiovascular, subjects with potentially have higher risk contracting Objectives To investigate prevalence among reported diagnosis COVID‐19 to measure association ED. Materials methods We reviewed data from Sex@COVID online survey (performed between April 7 May 4, 2020, in Italy) retrieve sample Italian male sexually active SARS‐CoV‐2 infection. A matching COVID‐19‐negative was also retrieved using propensity score 3:1 ratio. The used different standardized psychometric tools effects lockdown social distancing on intrapsychic, relational, sexual health subjects. Results One hundred were included analysis (25 COVID‐positive; 75 COVID‐negative). ED, measured Sexual Health Inventory for Men, significantly COVID+ group (28% vs. 9.33%; p = 0.027). Logistic regression models confirmed significant effect development independently other variables affecting erectile function, such psychological status, age, BMI [OR 5.66, 95% CI: 1.50–24.01]. Likewise, more likely COVID‐19, once corrected age 5.27, 1.49–20.09]. Discussion conclusion On top well‐described pathophysiological mechanisms, there is preliminary evidence real‐life population factor developing possibly occurring consequence Universal vaccination against personal protective equipment added benefit preventing dysfunctions.

Язык: Английский

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Endothelial cell dysfunction, coagulation, and angiogenesis in coronavirus disease 2019 (COVID-19)

Microvascular Research, Год журнала: 2021, Номер 137, С. 104188 - 104188

Опубликована: Май 20, 2021

Язык: Английский

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SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Март 7, 2022

Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability of SARS-CoV-2 infect replicate endothelial cells, it has been poorly investigated whether, complexity viral infection human host, specific elements alone can induce damage. Detection circulating spike protein sera severe COVID-19 patients was evaluated by ELISA.

Язык: Английский

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