Along with PaO2/FiO2 ratio and lymphopenia, low HLA-DR monocytes are the only additional parameter that independently predicts the clinical course of undifferentiated SARS-CoV-2 patients in emergency departments DOI
Thomas Lafon, Nicolas Chapuis,

Estelle Guérin

и другие.

Journal of Leukocyte Biology, Год журнала: 2024, Номер 115(6), С. 1131 - 1142

Опубликована: Фев. 15, 2024

Abstract Because one-third of patients deteriorate after their admission to the emergency department, assessing prognosis COVID-19 is great importance. However, date, only lymphopenia and partial pressure oxygen/fraction inspired oxygen (PaO2/FiO2) ratio have been reported as partly predictive COVID-19–related further deterioration, association has not evaluated. We asked whether other key biomarkers SARS-CoV-2 immunologic defects—increase in circulating immature granulocytes, loss monocyte HLA-DR (mHLA-DR) expression, differentiation blockade—could also predict deterioration. A series 284 consecutive patients, with sole inclusion criterion being an adult, were prospectively enrolled at department (day 0) 2 different hospitals: 1 for exploratory cohort (180 patients) confirmatory (104 patients). Deterioration was assessed over next 7 days. Neither increased granulocyte levels nor blockade predicted patient worsening. Among more than 30 clinical, biological, radiological parameters, value decreased P/F prediction deterioration strongly confirmed, mHLA-DR additional independent marker. Combined together a simple OxyLymphoMono score, 3 variables perfectly who did worsen correctly worsening 59% cases. By highlighting lymphocyte defects preceding these results point on early immunosuppression Combining ratio, lymphopenia, robust score could offer pragmatic method stratification.

Язык: Английский

Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection DOI Creative Commons
Mack B. Reynolds, Benjamin Y. Klein, Michael J. McFadden

и другие.

Cell Reports, Год журнала: 2024, Номер 43(8), С. 114607 - 114607

Опубликована: Авг. 1, 2024

Macrophage metabolic plasticity is central to inflammatory programming, yet mechanisms of coordinating and programs during infection are poorly defined. Here, we show that type I interferon (IFN) temporally guides control inflammation methicillin-resistant Staphylococcus aureus (MRSA) infection. We find staggered Toll-like receptor IFN signaling in macrophages permit a transient energetic state combined oxidative phosphorylation (OXPHOS) aerobic glycolysis followed by inducible nitric oxide synthase (iNOS)-mediated OXPHOS disruption. This disruption promotes IFN, suppressing other pro-inflammatory cytokines, notably interleukin-1β. Upon infection, iNOS expression peaks at 24 h, lactate-driven Nos2 repression via histone lactylation. Type pre-conditioning prolongs infection-induced expression, amplifying IFN. Cutaneous MRSA mice constitutively expressing epidermal results elevated levels, impaired wound healing, vasculopathy, lung Thus, kinetically regulated coordinates immunometabolic checkpoints inflammation.

Язык: Английский

Процитировано

5
Bacterial Community- and Hospital-Acquired Pneumonia in Patients with Critical COVID-19—A Prospective Monocentric Cohort Study DOI Creative Commons
Lenka Doubravská,

Miroslava Htoutou Sedláková,

Kateřina Fišerová

и другие.

Antibiotics, Год журнала: 2024, Номер 13(2), С. 192 - 192

Опубликована: Фев. 16, 2024

The impact of bacterial pneumonia on patients with COVID-19 infection remains unclear. This prospective observational monocentric cohort study aims to determine the incidence community- and hospital-acquired (CAP HAP) its effect mortality in critically ill admitted intensive care unit (ICU) at University Hospital Olomouc between 1 November 2020 31 December 2022. secondary objectives this include identifying etiology CAP HAP exploring capabilities diagnostic tools, a focus inflammatory biomarkers. Data were collected from electronic information hospital system, encompassing biomarkers, microbiological findings, daily visit records, subsequently evaluated by ICU physicians clinical microbiologists. Out 171 suffering critical COVID-19, 46 (27%) had CAP, while 78 (46%) developed HAP. Critically who experienced exhibited higher compared without any infection, rates 38% 56% versus 11%, respectively. In most frequent causative agents chlamydophila mycoplasma; Enterobacterales, which multidrug-resistant 71% cases; Gram-negative non-fermenting rods; Staphylococcus aureus. Notably, no strains Streptococcus pneumoniae detected, only single strain each Haemophilus influenzae Moraxella catarrhalis was isolated. etiologic causing Enterobacterales rods. Based presented results, commonly used biochemical markers demonstrated poor predictive accuracy. To confirm diagnosis our patient cohort, it necessary assess initial values (particularly procalcitonin), consider signs indicative and/or rely positive findings. For diagnostics, appropriate conduct regular detailed examinations (with evaluating respiratory functions) closely monitor dynamics (preferably Interleukin-6).

Язык: Английский

Процитировано

4
Recent insights and advances in gut microbiota's influence on host antiviral immunity DOI Creative Commons
Ying Liu,

Danying Yan,

Ran Chen

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Фев. 27, 2025

A diverse array of microbial organisms colonizes the human body, collectively known as symbiotic communities. Among various pathogen infections that hosts encounter, viral represent one most significant public health challenges worldwide. The gut microbiota is considered an important biological barrier against and may serve a promising target for adjuvant antiviral therapy. However, potential impact on infection remains relatively understudied. In this review, we discuss specific regulatory mechanisms in immunity, highlighting recent advances how regulate host immune response, produce immune-related molecules, enhance host's defense viruses. Finally, also oral probiotics.

Язык: Английский

Процитировано

0
Lianhuaqingwen capsule inhibits non-lethal doses of influenza virus-induced secondary Staphylococcus aureus infection in mice DOI
Jian Song, Jin Zhao,

Xuejun Cai

и другие.

Journal of Ethnopharmacology, Год журнала: 2022, Номер 298, С. 115653 - 115653

Опубликована: Авг. 19, 2022

Язык: Английский

Процитировано

16
Effect of Pneumococcal Conjugate Vaccines on Viral Respiratory Infections: A Systematic Literature Review DOI Creative Commons
Ingrid T. Sepúlveda-Pachón, Eileen M. Dunne, Germaine Hanquet

и другие.

The Journal of Infectious Diseases, Год журнала: 2024, Номер 230(3), С. e657 - e667

Опубликована: Март 11, 2024

Abstract Background In addition to preventing pneumococcal disease, emerging evidence indicates that conjugate vaccines (PCVs) might indirectly reduce viral respiratory tract infections (RTIs) by affecting pneumococcal-viral interactions. Methods We performed a systematic review of interventional and observational studies published during 2000–2022 on vaccine efficacy/adjusted effectiveness (VE) overall effect PCV7, PCV9, PCV10, or PCV13 against RTIs. Results Sixteen 1671 records identified were included. Thirteen publications described effects PCVs RTIs in children. VE influenza ranged between 41% 86% (n = 4), except for the 2010–2011 season. randomized controlled trial, PCV9 displayed efficacy any RTI, human seasonal coronavirus, parainfluenza, metapneumovirus. Data adults limited 3). was 4%–25% lower 32%–35% coronavirus disease 2019 outcomes, 24%–51% 13%–36% A with some 95% confidence intervals spanning zero. No protection found adenovirus rhinovirus children adults. Conclusions associated strongest Limited generally consistent pediatric data. Restricting public health evaluations confirmed outcomes may underestimate full impact PCVs.

Язык: Английский

Процитировано

3
Immunomodulatory Effects of Fluoroquinolones in Community-Acquired Pneumonia-Associated Acute Respiratory Distress Syndrome DOI Creative Commons
Resti Yudhawati,

Nisrina Fitriyanti Wicaksono

Biomedicines, Год журнала: 2024, Номер 12(4), С. 761 - 761

Опубликована: Март 29, 2024

Community-acquired pneumonia is reported as one of the infectious diseases that leads to development acute respiratory distress syndrome. The innate immune system first line defence against microbial invasion; however, its dysregulation during infection, resulting in an increased pathogen load, stimulates over-secretion chemokines and pro-inflammatory cytokines. This phenomenon causes damage epithelial–endothelial barrier pulmonary alveoli leakage intravascular protein into alveolar lumen. Fluoroquinolones are synthetic antimicrobial agents with immunomodulatory properties can inhibit bacterial proliferation well exhibit anti-inflammatory activities. It has been demonstrated structure fluoroquinolones, particularly those a cyclopropyl group, exerts effects. Its capability phosphodiesterase activity accumulation intracellular cAMP, which subsequently enhances PKA activity, inhibition transcriptional factor NF-κB activation CREB. Another mechanism TLR ERK signalling pathways. Although sequence events not completely understood, significant progress made comprehending specific mechanisms underlying effects fluoroquinolones. Here, we review indirect FQs alternative empirical therapy patients diagnosed community-acquired pneumonia.

Язык: Английский

Процитировано

3
Are secondary bacterial pneumonia mortalities increased because of insufficient pro-resolving mediators? DOI
Kevin Roe

Journal of Infection and Chemotherapy, Год журнала: 2024, Номер 30(10), С. 959 - 970

Опубликована: Июль 6, 2024

Язык: Английский

Процитировано

3
An anti-complement homogeneous polysaccharide from Houttuynia cordata ameliorates acute pneumonia with H1N1 and MRSA coinfection through rectifying Treg/Th17 imbalance in the gut–lung axis and NLRP3 inflammasome activation DOI Creative Commons
Xinxing Li, Wenxin Ding, Yan Lu

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Ratiometric Dual-Response Quantum Dot Spherical Nucleic Acid for Monitoring Viral Secondary Bacterial Infections DOI

Ai-Xin Ma,

Leping Lin, Qing Zhang

и другие.

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Viral-bacterial coinfections present intricate pathologies that exacerbate disease progression and elevate mortality rates. Understanding the dynamic interplay between viruses bacteria during coinfection is critical for developing effective therapeutic interventions. However, current diagnostic tools primarily rely on static detection methods, limiting their ability to monitor real-time infection dynamics. Here, we introduce a ratiometric, dual-responsive quantum dot spherical nucleic acid (QD-SNA) probe capable of simultaneously detecting viral- bacterial-specific markers in vivo. This enables monitoring coinfections, as demonstrated mouse model influenza virus (H1N1) methicillin-resistant Staphylococcus aureus infection. By providing dynamic, visual insights into process, QD-SNA holds significant potential preclinical drug screening diagnosis respiratory pathogen infections.

Язык: Английский

Процитировано

0
Dual Threat: Susceptibility Mechanisms and Treatment Strategies for COVID-19 and Bacterial Co-infections DOI Creative Commons
Keda Chen,

Ruiqi Weng,

Jiaxuan Li

и другие.

Computational and Structural Biotechnology Journal, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0