Chemistry of Heterocyclic Compounds, Год журнала: 2023, Номер unknown
Опубликована: Дек. 1, 2023
Язык: Английский
Nature Neuroscience, Год журнала: 2024, Номер 27(5), С. 836 - 845
Опубликована: Март 25, 2024
Язык: Английский
Процитировано
23
Tropical Medicine and Infectious Disease, Год журнала: 2022, Номер 7(10), С. 276 - 276
Опубликована: Сен. 29, 2022
With ongoing climate change, which alters the conditions for pathogens and vectors, zoonotic diseases such as monkeypox virus will become a challenge great threat impacting global health in future decades. A current outbreak of is occurring over 125 countries, with report thousands cases countries where this has never appeared. Occupational exposure to recently been identified an issue major concern occupational health, especially healthcare settings. scoping review following PRISMA guidelines was performed, aiming analyze effects that workplaces, given potential workers virus, possible spread settings, preventive measures are necessary implement. At end selection process, 21 studies were included review. Healthcare considered at high risk, similar those adopted during SARS-CoV-2 pandemic must be implemented all The main recommendations preventing managing settings vaccination exposed workers, prompt identification isolation infected individuals, good hygiene practices. Education specific training non-endemic make able recognize disease prevent further contagions. Although seems unlikely reach COVID-19, approach even avoid epidemics required by stakeholders.
Язык: Английский
Процитировано
47
Materials, Год журнала: 2024, Номер 17(6), С. 1355 - 1355
Опубликована: Март 15, 2024
The paper presents the new eco-friendly method of bleaching process cellulose fibre materials. Cellulose materials were bleached using hydrogen peroxide (both in aqueous solution, vapours, ozone and by combined action gaseous ozone. solution standard procedure was used as comparison technique. processes oxidants carried out a prototype device for dry, low-temperature treatment fibrous with use oxidising agents gas phase. influence innovative gas-phase on cotton samples' properties analysed Scanning Electron Microscopy (SEM), evaluation colour whiteness, assessment polymerisation degree (DP), analysis mechanical sorption capacity well microbiological against colonies Gram-positive (Staphylococcus aureus) Gram-negative (Escherichia coli) bacteria. obtained results led to conclusion that agents-vaporised peroxide, or their combination-are non-invasive. applied resulted slightly lower whiteness parameters than bath bleaching. After vaporised separately, decrease DP tensile strength similar observed after H2O2. When both together, higher reduction noticed. Both showed strong biocidal effect Gas-phase procedures, due temperature (35 °C vs. 98 °C) minimal water consumption, have economic environmental advantages, which allows semi-industrial applications. It has been shown fabrics phase simultaneously obtain disinfection effect.
Язык: Английский
Процитировано
17
Molecules, Год журнала: 2025, Номер 30(7), С. 1419 - 1419
Опубликована: Март 22, 2025
Introduction: Currently, there are no effective medications for treating all the clinical conditions of patients with COVID-19. We aimed to evaluate antiviral activity compounds derived from L-tyrosine against B.1 lineage SARS-CoV-2 in vitro and silico. Methodology: The cytotoxicities 15 halogenated were evaluated Vero-E6 cells by MTT assay. was using four strategies, viral quantification performed a plaque assay qRT-PCR. toxicity ADMET predictor software. affinity these or cellular proteins stability their conformations determined docking molecular dynamics, respectively. Results: TODC-3M, TODI-2M, YODC-3M reduced titer >40% inhibited replication RNA without significant cytotoxicity. In silico analyses revealed that presented low binding energies between −4.3 −5.2 Kcal/mol three (spike, Mpro, RdRp). TODC-3M most stable proteins. Conclusions: promising YODC-3M, which toxicity, potential through different favorable affinities targets. Therefore, they candidates vivo studies.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 244, С. 125388 - 125388
Опубликована: Июнь 15, 2023
Язык: Английский
Процитировано
20
Carbohydrate Research, Год журнала: 2024, Номер 538, С. 109098 - 109098
Опубликована: Март 21, 2024
Язык: Английский
Процитировано
8
Veterinary Sciences, Год журнала: 2024, Номер 11(2), С. 78 - 78
Опубликована: Фев. 7, 2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in a zoological institution were initially reported March 2020. Since then, at least 94 peer-reviewed cases have been zoos worldwide. Among the affected animals, nonhuman primates, carnivores, and artiodactyls appear to be most susceptible infection, with Felidae family accounting for largest number of cases. Clinical symptoms tend mild across taxa; although, certain species exhibit increased susceptibility disease. A variety diagnostic tools are available, allowing initial diagnostics monitoring infectious risk. Whilst supportive therapy proves sufficient cases, monoclonal antibody has emerged as promising additional treatment option. Effective transmission SARS-CoV-2 some raises concerns over potential spillover formation reservoirs. The occurrence animal may contribute emergence variants concern due altered viral evolutionary constraints. Consequently, this review emphasizes need effective biosecurity measures surveillance strategies prevent control institutions.
Язык: Английский
Процитировано
6
Journal of Hazardous Materials, Год журнала: 2024, Номер 465, С. 133458 - 133458
Опубликована: Янв. 9, 2024
Язык: Английский
Процитировано
5
International Journal of Pharmaceutics, Год журнала: 2024, Номер 651, С. 123779 - 123779
Опубликована: Янв. 4, 2024
Prolonged and excessive use of biocides during the coronavirus disease era calls for incorporating new antiviral polymers that enhance surface design functionality existing potential future pandemics. Herein, we investigated previously unexplored polyamines with nucleophilic biguanide, guanidine, hydantoin groups all can be halogenated leading to high contents oxidizing halogen enables enhancement biocidal activity. Primary amino used attach poly(N-vinylguanidine) (PVG) poly(allylamine-co-4-aminopyridine-co-5-(4-hydroxybenzylidene)hydantoin) (PAH) as well a broad-spectrum commercial biocide poly(hexamethylene biguanide) (PHMB) onto solid support. Halogenation polymer suspensions was conducted through in situ generation excess hypobromous acid (HBrO) from bromine sodium hydroxide or by hypochlorite aqueous solutions, resulting N-halamines active > N-Br N-Cl groups. The virucidal activity against human respiratory HCoV-229E increased dramatically their halogenation. Brominated PHMB-Br showed activation value 5 even at 1 mg/L, complete virus inhibition observed either PAH-Br 10 mg/mL. PVG-Br possessed fungicidal C. albicans, while PHMB fungistatic. PHMB, PAH demonstrated excellent bactericidal methicillin-resistant S. aureus vancomycin-resistant E. faecium. (PHMB-Br, PVG-Br, PAH-Br) were not toxic HeLa monolayers, indicating acceptable biocompatibility cultured cells. With these features, N-halamine present study are worthwhile addition arsenal promising candidates development non-leaching coatings.
Язык: Английский
Процитировано
5
The Science of The Total Environment, Год журнала: 2024, Номер 958, С. 178020 - 178020
Опубликована: Дек. 16, 2024
Язык: Английский
Процитировано
5