Design peptide and multi-epitope protein vaccine candidates against monkeypox virus using reverse vaccinology approach: an in-silico study

Journal of Biomolecular Structure and Dynamics, Год журнала: 2023, Номер 41(23), С. 14398 - 14418

Опубликована: Май 8, 2023

Monkeypox is a zoonotic virus that has recently affected different countries worldwide. On July 23, 2022, the WHO declared outbreak of monkeypox as public health emergency international concern. Surveillance studies conducted in Central Africa 1980s and later during outbreaks same region showed smallpox vaccines to be clinically somewhat effective against virus. However, there no specific vaccine this This research used bioinformatics techniques establish novel multi-epitope candidate can induce strong immune response. Five well-known antigenic proteins (E8L, A30L, A35R, A29L, B21R) were picked assessed possible immunogenic peptides. Two suitable peptide candidates selected according bio-informatics analysis. Based upon silico evaluation, two (ALALAR ALAL) built with rich-epitope domains consisting high-ranking T B-cell epitopes. After predicting evaluating 3D structure protein candidates, most efficient models considered for docking Toll-like receptor 4 (TLR4) HLA-A * 11:01, HLA-A*01:01, HLA-A*02:01, HLA-A*03:01, HLA-A*07:02, HLA-A*15:01, HLA-A*30:01 receptors. Subsequently, molecular dynamics (MD) simulation up 150 nanoseconds was employed assess durability interaction MD M5-HLA-A*11:01, ALAL-TLR4, ALALAR-TLR4 complexes stable simulation. Analysis outcomes indicates M5 ALAL ALALAR may virus.Communicated by Ramaswamy H. Sarma

Язык: Английский

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Recent Advances in Monkeypox (Mpox): Characterization, Diagnosis, and Therapeutics - A Multidimensional Review

Authorea (Authorea), Год журнала: 2023, Номер unknown

Опубликована: Июль 4, 2023

Monkeypox (Mpox) is an uncommon viral infection closely related to smallpox, manifesting as a milder febrile rash in affected individuals. Over the past two decades, incidence of Mpox has surged, possibly linked declining immunity against smallpox vaccine worldwide. Recent outbreaks multiple countries have sparked concerns regarding altered transmission patterns and potential for global menace. In this article, we present multidimensional review, encompassing latest scientific discoveries, illuminating intricate structure human virus. Additionally, explore noteworthy breakthroughs diagnostic techniques therapeutic interventions. By shedding light on molecular aspects, epidemiological trends, clinical manifestations, our review aims facilitate comprehensive understanding Mpox, providing critical insights field virology guiding public health efforts combating emerging threat.

Язык: Английский

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The 2022 monkeypox outbreak 1 year on: The 5 Ws

Reviews in Medical Virology, Год журнала: 2023, Номер 34(1)

Опубликована: Ноя. 6, 2023

Abstract In May 2022, World Health Organization (WHO) reported an outbreak of Mpox in several European countries which were previously free. (formerly known as monkeypox) is a zoonotic viral disease endemic Central and West Africa. The sudden emergence outside Africa its subsequent rapid spread lead the WHO to declare Public Emergency International Concern. By 15 2023, total 87,704 confirmed cases 140 deaths had been from 111 territories worldwide. Looking back on this 1 year later, important questions have arisen. Here, we address these using classic 5 Ws: What, When, Where, Who Why? We discuss understand how emerged it was effectively managed. outline what needs be done prevent, or at least minimise, outbreaks due emerging re‐emerging infections.

Язык: Английский

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Espectro de manejo farmacológico de la infección por viruela del mono durante el brote de 2022

Universitas Médica, Год журнала: 2024, Номер 64(4)

Опубликована: Янв. 31, 2024

Para esta revisión de la literatura, se describieron las propuestas planteadas para el manejo farmacológico infección por viruela del mono (Mpox) durante brote 2022. Con ese objetivo, realizó una búsqueda sistematizada literatura utilizando palabras claves: infections, monkeypox, therapeutics, treatment efficacy en Medline, a través PubMed, donde identificaron 54 artículos publicados desde 2001 2023, los cuales seleccionaron 26 ser incluidos resultados. Se encontró que tratamientos más documentados tratar Mpox fueron tecovirimat, seguido cidofovir y brincidofovir. El tecovirimat fue opción terapéutica segura eficaz, con capacidad reducir carga viral tasa supervivencia al menos un 90 %. Sin embargo, ninguno tres medicamentos ha aprobado Administración Alimentos Medicamentos Estados Unidos tratamiento Mpox, lo reconoce importancia llevar cabo estudios dirigidos establecer esquemas mundial, considerando es potencial arma biológica todo planeta.

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Pockenvirusinfektionen in der Dermatologie

JDDG Journal der Deutschen Dermatologischen Gesellschaft, Год журнала: 2024, Номер 22(1), С. 56 - 96

Опубликована: Янв. 1, 2024

Zusammenfassung Die Familie Poxviridae umfasst derzeit 22 Gattungen, die Wirbeltiere infizieren können. Humanpathogene Pockenviren gehören den Gattungen Ortho‐ , Para‐ Mollusci‐ und Yatapoxvirus an. Bis zur Eradikation der Variola vera im Jahr 1979 waren Pocken, Volksmund auch Blattern genannt, eine schwerwiegende Gesundheitsbedrohung für Bevölkerung. Noch heute sind Dermatologen mit zahlreichen Pockenvirusinfektionen konfrontiert, wie Bauernhofpocken, als Zoonosen nach Tierkontakten in ländlichen Gebieten oder Massenversammlungen auftreten In Tropen können Erkrankungen durch Tanapox‐ Vaccinia‐Viren zu Differenzialdiagnosen gehören. Dellwarzen weltweit verbreitet werden bestimmten Fällen sexuell übertragbare Pockenvirusinfektion angesehen. jüngster Zeit hatten sich Mpox (Affenpocken) einer gesundheitlichen Notlage von internationaler Tragweite entwickelt, rasche Identifizierung angemessene Behandlung Infektiologen erfordert. Fortschritte neue Erkenntnisse über Epidemiologie, Diagnose, klinische Manifestationen Komplikationen sowie Prävention erfordern ein hohes Maß an Fachwissen interdisziplinärer Zusammenarbeit Bereichen Virologie, Infektiologie Dermatologie. Dieser CME‐Artikel bietet einen aktualisierten systematischen Überblick, um praktizierende bei Identifizierung, Differenzialdiagnose klinisch relevanter unterstützen.

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