Rhinovirus—A True Respiratory Threat or a Common Inconvenience of Childhood?

Viruses, Год журнала: 2023, Номер 15(4), С. 825 - 825

Опубликована: Март 24, 2023

A decade-long neglect of rhinovirus as an important agent disease in humans was primarily due to the fact that they were seen less virulent and capable causing only mild respiratory infections such common cold. However, with advent molecular diagnostic methods, increasing number reports placed them among pathogens found lower tract recognized risk factors for asthma-related pathology childhood. As spread not severely affected by implementation social distancing other measures during coronavirus 2019 (COVID-19) pandemic, its putative pathogenic role has become even more evident recent years. By concentrating on children most vulnerable group, this narrative review we first present classification main traits rhinovirus, followed epidemiology clinical presentation, severe forms disease, long-term complications pathogenesis asthma, well a snapshot treatment trials studies. Recent evidence suggests is significant contributor illness both high-risk low-risk populations children.

Язык: Английский

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The prevalence of childhood asthma: interpreting falling rates in the context of shifting measurement and the COVID-19 pandemic

Current Opinion in Pulmonary Medicine, Год журнала: 2023, Номер 29(3), С. 197 - 201

Опубликована: Март 14, 2023

The estimated prevalence of childhood asthma in the United States, as measured by National Health Information Survey (NHIS), has decreased 30% since 2017. This review provides context for observed changes rates describing recent shifts NHIS data collection and analysis, considers whether COVID-19 pandemic might impact years to come.The underwent a planned redesign 2019 with updated sampling weights better match U.S. population. In early 2020, resulted unplanned modifications implementation, which may have included fewer children from populations at heightened risk asthma. Decreasing estimates are likely least part due these survey rather than true epidemiologic shift. However, pandemic-related factors (including exposure rhinovirus infections allergic sensitization) also influence future.Recent USA driven methods both before during pandemic. Additional needed determine shift disease is occurring.

Язык: Английский

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Circulation pattern and genetic variation of rhinovirus infection among hospitalized children on Hainan Island, before and after the dynamic zero‐COVID policy, from 2021 to 2023

Journal of Medical Virology, Год журнала: 2024, Номер 96(6)

Опубликована: Июнь 1, 2024

Throughout the COVID-19 pandemic, rhinovirus (RV) remained notable persistence, maintaining its presence while other seasonal respiratory viruses were largely suppressed by pandemic restrictions during national lockdowns. This research explores epidemiological dynamics of RV infections among pediatric populations on Hainan Island, China, specifically focusing impact before and after zero-COVID policy was lifted. From January 2021 to December 2023, 19 680 samples collected from patients hospitalized with acute lower tract (ARTIs) at Maternal Child Health Hospital. The infection detected tNGS. species subtypes identified in 32 RV-positive representing diverse time points analyzing VP4/VP2 partial regions. Among inpatients ARTIs analyzed, 21.55% found be positive for infection, peaks observed April November 2022. A gradual annual decline observed, alongside a pattern higher prevalence colder months. highest proportion 0-1-year age group. Phylogenetic analysis indicated trend RV-A RV-C observation suggests potential evolving within although further studies are needed due limited sample size. emphasizes necessity ongoing surveillance targeted management, particularly highly susceptible severe illnesses caused infections.

Язык: Английский

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Increasing rhinovirus prevalence in paediatric intensive care patients since the SARS-CoV2 pandemic

Journal of Clinical Virology, Год журнала: 2023, Номер 166, С. 105555 - 105555

Опубликована: Июль 30, 2023

Rhinovirus (HRV) is a significant seasonal pathogen in children. The emergence of SARS-CoV2, and the social restrictions introduced in, disrupted viral epidemiology. Here we describe experience Great Ormond Street Hospital (GOSH), where HRV almost entirely disappeared from paediatric intensive care units (PICU) during first national lockdown then rapidly re-emerged with fast-increasing incidence, leading to concerns about possible nosocomial transmission vulnerable population.To alterations infection amongst PICU patients at GOSH since SARS-COV2 STUDY DESIGN: 10,950 nasopharyngeal aspirate PCR samples 2019 2023 were included. 3083 returned positive result for respiratory virus, 1530 HRV. 66 isolates August 2020 - Jan 2021, period increasing sequenced. Electronic health record data was retrospectively collected same period.Following reduction incidence lockdown, multiple genotypes emerged patients, surging levels higher than that seen prior SARS-CoV2 continuing circulate increased year-round.The markedly pattern not other viruses. burden HRV-infection has both clinical prevention control Implications.

Язык: Английский

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Surveillance of Influenza and Other Airborne Transmission Viruses during the 2021/2022 Season in Hospitalized Subjects in Tuscany, Italy

Vaccines, Год журнала: 2023, Номер 11(4), С. 776 - 776

Опубликована: Март 31, 2023

Winter in the northern hemisphere is characterized by circulation of influenza viruses, which cause seasonal epidemics, generally from October to April. Each season has its own pattern, differs one year next terms first case notification, period highest incidence, and predominant virus subtypes. After total absence viruses 2020/2021 season, cases were again recorded 2021/2022 although they remained below average. Moreover, co-circulation SARS-CoV-2 pandemic was also reported. In context DRIVE study, oropharyngeal swabs collected 129 Tuscan adults hospitalized for severe acute respiratory infection (SARI) analyzed means real-time polymerase chain reaction (RT-PCR) 21 different airborne pathogens, including viruses. total, 55 subjects tested positive COVID-19, 9 influenza, 3 both A/H3N2 virus. The population requires strengthened surveillance that no longer restricted winter months. Indeed, constant, year-long monitoring trends these needed, especially at-risk groups elderly people.

Язык: Английский

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Interferons as negative regulators of ILC2s in allergic lung inflammation and respiratory viral infections

Journal of Molecular Medicine, Год журнала: 2023, Номер 101(8), С. 947 - 959

Опубликована: Июль 6, 2023

Язык: Английский

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Social distancing during the COVID-19 pandemic: Potential impact and correlation with asthma

Heart & Lung, Год журнала: 2024, Номер 68, С. 18 - 22

Опубликована: Июнь 13, 2024

Язык: Английский

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Effects of Nonpharmaceutical Interventions during COVID-19 Pandemic on Pediatric Asthma Exacerbations and Viral Infections.

Journal of Allergy and Clinical Immunology Global, Год журнала: 2024, Номер 3(4), С. 100340 - 100340

Опубликована: Сен. 11, 2024

Язык: Английский

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Circulation Pattern and Genetic Variation of Rhinovirus Infection among Hospitalized Children on Hainan Island, before and after the Dynamic Zero-COVID Policy, from 2021 to 2023

Authorea (Authorea), Год журнала: 2024, Номер unknown

Опубликована: Май 20, 2024

Objective Throughout the COVID-19 pandemic, Rhinovirus (RV) remained notable persistence, maintaining its presence while other seasonal respiratory viruses were largely suppressed by pandemic restrictions during national lockdowns. This research explores epidemiological dynamics of RV infections among pediatric populations on Hainan Island, China, specifically focusing impact before and after zero-COVID policy was lifted. Methods From January 2021 to December 2023, 19,680 samples collected from patients hospitalized with acute lower tract (ARTIs) at Maternal Child Health Hospital. The infection detected tNGS. species subtypes identified in 32 RV-positive representing diverse time points analyzing VP4/VP2 partial regions. Results Among inpatients ARTIs analyzed, 21.55% found be positive for infection, peaks observed April November 2022. A gradual annual decline observed, alongside a pattern higher prevalence colder months. highest proportion 0-1 year age group. Phylogenetic analysis revealed 23 distinct subtypes, shift dominance RV-A RV-C 2022, suggesting evolving dynamics. Conclusions emphasizes necessity ongoing surveillance targeted management, particularly highly susceptible severe illnesses caused infections.

Язык: Английский

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In silico molecular screening of bioactive natural compounds of rosemary essential oil and extracts for pharmacological potentials against rhinoviruses

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 29, 2024

Rhinoviruses (RVs) cause upper respiratory tract infections and pneumonia in children adults. These non-enveloped viruses contain viral coats of four capsid proteins: VP1, VP2, VP3, VP4. The canyon on VP1 used cell surface receptor ICAM-1 as the site attachment for internalization viruses. To date, there has been no drug or vaccine available against RVs. In this study, bioactive natural compounds rosemary (Salvia rosmarinus L.), which are known their pharmacological potential, were considered to target protein. A total 30 taken ligands proteins. PkCSM tool was detect adherence Lipinski's rule five ADMET properties selected ligands. Further, CB-Dock molecular docking studies between protein Based profiling results, phenethyl amine (4 methoxy benzyl) lead compound. comparative study performed compound two antiviral drugs, Placonaril Nitazoxanide, investigate higher potential over synthetic drugs. also targets but failed clinical trials while Nitazoxanide examined rhinoviruses. It discovered from that exhibited less toxicity comparison other tested drugs More research is needed determine its make it a good medication

Язык: Английский

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