Antiviral Research, Год журнала: 2025, Номер unknown, С. 106172 - 106172
Опубликована: Май 1, 2025
Язык: Английский
Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)
Опубликована: Апрель 22, 2024
Abstract Dengue viruses (DENV) are positive-stranded RNA belonging to the Flaviviridae family. DENV is causative agent of dengue, most rapidly spreading viral disease transmitted by mosquitoes. Each year, millions people contract virus through bites from infected female mosquitoes Aedes species. In majority individuals, infection asymptomatic, and immune system successfully manages control replication within a few days. Symptomatic individuals may present with mild fever (Dengue or DF) that not progress more critical termed hemorrhagic (DHF) fatal shock syndrome (DSS). absence universally accepted prophylactic vaccine therapeutic drug, treatment mostly restricted supportive measures. Similar many other induce acute illness, has developed several ways modulate host metabolism create an environment conducive genome dissemination progeny. To search for new options, understanding underlying host-virus regulatory involved in various biological processes life cycle essential. This review aims summarize complex interaction between cellular machinery, comprising mechanisms at molecular levels such as epigenetic modulation genome, transcription genes, translation mRNAs, post-transcriptional regulation transcriptome, post-translational proteins, pathways protein degradation.
Язык: Английский
Процитировано
29
npj Viruses, Год журнала: 2024, Номер 2(1)
Опубликована: Июнь 21, 2024
Abstract Dengue virus (DENV) is the most prevalent arthropod-borne flavivirus and imposes a significant healthcare threat worldwide. At present no FDA-approved specific antiviral treatment available, safety of vaccine against DENV still on debate. Following its entry into host cell, takes advantage cellular secretory pathway to produce new infectious particles. The key organelle cell in infections endoplasmic reticulum (ER) which supports various stages throughout entire life cycle flaviviruses. This review delves intricate interplay between flaviviruses ER during their with focus molecular mechanisms underlying viral replication, protein processing virion assembly. Emphasizing significance cycle, we highlight potential targets ER-related steps replication summarize current drugs that are (pre)clinical developmental stage. Insights exploitation by offer promising avenues for development targeted strategies, providing foundation future research therapeutic interventions
Язык: Английский
Процитировано
8
Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
1
Viruses, Год журнала: 2025, Номер 17(1), С. 74 - 74
Опубликована: Янв. 8, 2025
Flaviviruses are a diverse group of viruses primarily transmitted through hematophagous insects like mosquitoes and ticks. Significant expansion in the geographic range, prevalence, vectors flavivirus over last 50 years has led to dramatic increase infections that can manifest as hemorrhagic fever or encephalitis, leading prolonged morbidity mortality. Millions every year pose serious threat worldwide public health, encouraging scientists develop better understanding pathophysiology immune evasion mechanisms these for vaccine development antiviral therapy. Extensive research been conducted developing effective antivirals flavivirus. Various approaches have extensively utilized clinical trials development, targeting virus entry, replication, polyprotein synthesis processing, egress pathways exploiting well host proteins. However, date, no licensed drug exists treat diseases caused by viruses. Understanding host-pathogen interaction, immunity, viral evasion, disease pathogenesis is highly warranted foster antivirals. This review provides an detailed summary most recent advances drugs combat diseases.
Язык: Английский
Процитировано
1
Heliyon, Год журнала: 2025, Номер unknown, С. e41939 - e41939
Опубликована: Янв. 1, 2025
Dengue virus represents a global public health threat, being prevalent in tropical and subtropical regions, with an increasing geographical distribution rising incidence worldwide. This mosquito-borne viral agent causes wide range of clinical manifestations, from mild febrile illness to severe cases potentially fatal outcomes due hemorrhage shock syndrome. The etiological agent, dengue (DENV), has four distinct serotypes, each capable inducing outcomes. current therapeutic landscape remains limited, management strategies mainly focused on supportive cares. However, recent advances pharmaceutical research have yielded promising developments anti-dengue drugs. Extensive investigations been conducted various synthetic compounds, including JNJ-1802, 1,4-pyran naphthoquinones, arylnaphthalene lignan derivatives. Additionally, natural compounds derived medicinal plants such as Hippophae rhamnoides, Azadirachta indica, Cymbopogon citratus demonstrated potential antiviral properties both vitro vivo studies, based inhibition DENV replication. none these are date approved by the U.S. Food Drug Administration (FDA). Although many vaccines recognized candidates stages trials, only limited number protective efficacy against infection. aspect underscores need for highly effective immunization interventions, whether botanical sources or through manufacturing, that exhibit low adverse effects. review examines innovative approaches prevention treatment, encompassing phytochemical strategies.
Язык: Английский
Процитировано
1
Parasites & Vectors, Год журнала: 2025, Номер 18(1)
Опубликована: Янв. 29, 2025
Язык: Английский
Процитировано
1
Viruses, Год журнала: 2024, Номер 16(5), С. 725 - 725
Опубликована: Май 3, 2024
The dengue virus is a single-stranded, positive-sense RNA that infects ~400 million people worldwide. Currently, there are no approved antivirals available. CRISPR-based screening methods have greatly accelerated the discovery of host factors essential for DENV infection and can be targeted in host-directed antiviral interventions. In present study, we performed focused CRISPR (Clustered Regularly Interspaced Palindromic Repeats) library screen to discover key human Huh7 cells identified Protein Activator Interferon-Induced Kinase (PACT) as novel pro-viral factor DENV. PACT double-stranded RNA-binding protein generally known activate responses virus-infected block viral replication. However, our studies, observed plays role specifically promotes Knockout resulted significant decrease abundances infected cells, which was rescued upon ectopic expression full-length PACT. An analysis global gene changes indicated several ER-associated genes such ERN1, DDIT3, HERPUD1, EIF2AK3 not upregulated DENV-infected knockout compared wildtype cells. Thus, study demonstrates promoting replication, possibly through modulating genes.
Язык: Английский
Процитировано
6
Nano Letters, Год журнала: 2024, Номер 24(46), С. 14541 - 14551
Опубликована: Авг. 28, 2024
Millions of cases dengue virus (DENV) infection yearly from Aedes mosquitoes stress the need for effective antivirals. No current drug effectively combats efficiently. Transient immunity and severe risks highlight broad-spectrum antivirals targeting all serotypes DENV. Niclosamide, an antiparasitic, shows promising antiviral activity against virus, but enhancing its bioavailability is challenging. To overcome this issue enable niclosamide to address global problem, nanoengineered niclosamides can be solution. Not only does it cost issues also with effects offers hope in addressing health crisis associated DENV will play a crucial role combating other arboviruses as well.
Язык: Английский
Процитировано
6
Brain, Год журнала: 2023, Номер 147(3), С. 830 - 838
Опубликована: Дек. 9, 2023
Abstract Dengue virus is a flavivirus transmitted by the mosquitoes, Aedes aegypti and albopictus. infection all four serotypes (DEN 1 to 4) endemic globally in regions with tropical subtropical climates, an estimated 100–400 million infections annually. Among those hospitalized, mortality about 1%. Neurological involvement has been reported be 5%. The spectrum of neurological manifestations spans both peripheral central nervous systems. These could possibly categorized into directly related dengue infection, i.e. acute chronic encephalitis, indirect complications leading encephalopathy, post-infectious syndrome due immune-mediated reactions, uncertain mechanisms, such as transverse myelitis, cerebellitis myositis. rising trend global incidence calls for attention more explicit definition each manifestation accurate epidemiological data. actual burden essential future planning execution strategies, especially development effective antivirals vaccines against virus. In this article, we discuss recent findings different spectrums provide update on antiviral vaccine their challenges.
Язык: Английский
Процитировано
12
Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(15), С. 12534 - 12552
Опубликована: Июль 19, 2024
Macrocyclization of acyclic compounds is a powerful strategy for improving inhibitor potency and selectivity. Here we have optimized 2-aminopyrimidine-based macrocycles to use these as chemical tools the ephrin kinase family. Starting with promiscuous macrocyclic inhibitor,
Язык: Английский
Процитировано
5