Biomedical and Nutritional Applications of Lactoferrin

International Journal of Peptide Research and Therapeutics, Год журнала: 2023, Номер 29(5)

Опубликована: Июль 4, 2023

Abstract Lactoferrin (Lf) is a glycoprotein belonging to the transferrin family, which can be found in mammalian milk. It was first isolated from bovine milk 1930s, and later 1960s, it determined human This multifunctional protein has specific ability bind iron. plays various biological roles, such as antibacterial, antiviral, antifungal, anti-tumour, anti-obesity, antioxidant, anti-inflammatory immunomodulatory activities. There are several studies describing its use against cancer cell lines (e.g., liver, lung breast) even been reported inhibit development of experimental metastases mice. Previous also suggest Lf-mediated neuroprotection age-related neurodegenerative diseases expected attenuate aging. More recently, Lf proposed potential approach COVID-19 prophylaxis. In this review, we discuss recent developments about activities pleiotropic that will reason exploitation biomedical supplementary nutritional value.

Язык: Английский

---

Is there sufficient evidence to support the health benefits of including donkey milk in the diet?

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Сен. 25, 2024

Donkey milk has attracted attention due to its distinctive nutritional composition and potential health advantages, particularly because of whey protein content, which includes lysozyme,

Язык: Английский

---

Lactoferrin: A Promising Therapeutic Molecule against Human Papillomavirus

Nutrients, Год журнала: 2024, Номер 16(18), С. 3073 - 3073

Опубликована: Сен. 12, 2024

Lactoferrin is a multifunctional glycoprotein naturally found in mammalian secretions, predominantly colostrum and milk. As key component of dairy foods, lactoferrin enhances viral protection boosts human health, owing to its fundamental properties including antiviral, anti-inflammatory, immune-modulatory effects. Importantly, the antiviral effect has been shown against range viruses causing serious infections threatening health. One that exerts significant effects on papillomavirus (HPV), which most prevalent transmitted infection affecting myriad people around world. high potential inhibit HPV via different mechanisms, direct binding envelope proteins or their cell receptors, thereby hindering entry immune stimulation by triggering release some immune-related molecules through body, such as lymphocytes. Along with HPV, also can coronaviruses hepatitis same manner. Here, we overview current knowledge other infections.

Язык: Английский

---

Antiviral properties of milk proteins and peptides against SARS-COV-2: A review

Journal of Functional Foods, Год журнала: 2024, Номер 117, С. 106237 - 106237

Опубликована: Май 15, 2024

Certain milk proteins and peptides exhibit promising immunogenic antiviral properties, particularly against coronaviruses like SARS-CoV-2. Amidst the global pandemic, these bioactive components present potential alternatives for combating viral diseases. Milk are known to play important roles functioning in various stages of SARS-CoV-2 replication cycle, including entry, endocytic processes, replication, cell signaling modulation. Notably, bovine lactoferrin, is reported synergistically enhance effects remdesivir, an FDA-approved anti-SARS-CoV-2 drug. Peptides derived from have demonstrated some efficacy both vitro silico studies. While findings highlight as natural agents, further validation through vivo studies clinical trials imperative determine their efficacy, safety, optimal dosages. This review provides a comprehensive exploration specific peptides.

Язык: Английский

---

A comprehensive review of research advances in the study of lactoferrin to treat viral infections

Life Sciences, Год журнала: 2024, Номер unknown, С. 123340 - 123340

Опубликована: Дек. 1, 2024

Язык: Английский

---

Lactoferrin exhibits PEDV antiviral activity by interfering with spike-heparan sulfate proteoglycans binding and activating mucosal immune response

Veterinary Research, Год журнала: 2025, Номер 56(1)

Опубликована: Янв. 31, 2025

Язык: Английский

---

Lactoferrin: Properties and Potential Uses in the Food Industry

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1404 - 1404

Опубликована: Фев. 7, 2025

Lactoferrin (LF) is an 80 kDa glycoprotein that contains approximately 700 amino acids and a member of the transferrin family. The essential properties LF, including antimicrobial, antiviral, anticancer, anti-inflammatory, antioxidant, probiotic effects, have been studied for decades. iron chelation activity LF significantly associated with its antioxidant properties. Owing to prebiotic activity, also facilitates growth beneficial microorganisms iron-defense immediate-effect on pathogens. Additionally, ability regulate cell signaling pathways immune responses makes prominent modulatory protein. These diverse characteristics gained interest in therapeutic potential. Studies suggested could serve as alternative source antibiotics severe infections illnesses. has food industry potential additive fortify products such yogurt, infant formula, meat derivatives while improving shelf life foods providing antimicrobial activity. Prior using industry, safety toxicity processing are necessary be investigated. investigations crucial addressing harm or side effects ensuring healthy lifestyle. This review discusses attributes particularly exploitation industry.

Язык: Английский

---

Lactoferrin in Health and Disease: A Review of Its Bioavailability and Evidence-Based Benefits Across Study Models

Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 105024 - 105024

Опубликована: Апрель 1, 2025

Язык: Английский

---

Combination of Nanodelivery Systems and Constituents Derived from Novel Foods: A Comprehensive Review

Pharmaceutics, Год журнала: 2023, Номер 15(11), С. 2614 - 2614

Опубликована: Ноя. 11, 2023

Novel Food is a new category of food, regulated by the European Union Directive No. 2015/2283. This latter norm defines food as “Novel” if it was not used “for human consumption to significant degree within before date entry into force that regulation, namely 15 May 1997”. Recently, Foods have received increased interest from researchers worldwide. In this sense, key areas are discovery benefits for health and exploitation these novel sources materials in fields application. An emerging area pharmaceutical medicinal nanotechnology, which deals with development delivery systems at nanometric scale. context, review aims summarize recent advances on design characterization nanodelivery based belonging list, well nanoceutical products formulated delivering compounds derived Foods. Additionally, safety hazard using nanoparticles products, i.e., supplements, has been discussed view current considers nanomaterials

Язык: Английский

---

Comparative In Vitro Study between Biocompatible Chitosan-Based Magnetic Nanocapsules and Liposome Formulations with Potential Application in Anti-Inflammatory Therapy

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8454 - 8454

Опубликована: Авг. 2, 2024

This study describes the comparison between interaction of a series peptide-functionalized chitosan-based nanocapsules and liposomes with two cell lines, i.e., mouse macrophages RAW 264.7 human endothelial cells EA.hy926. Both types nanocarriers are loaded magnetic nanoparticles designed for anti-inflammatory therapy. The choice these nanostructures is argued based on their advantages in terms size, morphology, chemical composition, multiple possibilities modifying surface. Moreover, active targeting might be ensured by using an external field. To explore impact cytophysiology, viability, MTT assay, morphology were investigated. results revealed low to moderate cytotoxicity free significant induced chitosan-coated dexamethasone, confirming its release from delivery system. Thus, after 48 h treatment nanocapsules, viability varied 88.18% (OCNPM-1I, 3.125 µg/mL) 76.37% (OCNPM-1, 25 µg/mL). In same conditions, EA.hy926 was 99.91% (OCNPM-3, 75.15% at highest dose (25 µg/mL), values being comparable both lines. Referring reactivity dexamethasone-loaded liposome application, lowest 41.25% (CLDM5CP-1, 58.20% (CLDMM2CP-1 1.25 line, proving selective character action nanocarriers. test, performed support confirm obtained differentiated response nano-carriers. As expected, intense cytotoxic effect case lack drug-free noticed. Therefore, our demonstrated biocompatible feature studied nanocarriers, which highlights them future research as potential drug systems pharmacological applications, including

Язык: Английский

---