Very low-calorie ketogenic diet (VLCKD) in the management of hidradenitis suppurativa (Acne Inversa): an effective and safe tool for improvement of the clinical severity of disease. Results of a pilot study

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Фев. 13, 2024

Abstract Background Hidradenitis suppurativa (HS), an inflammatory-based dermatological condition often associated with obesity, poses significant challenges in management. The very low-calorie ketogenic diet (VLCKD) has shown efficacy addressing related metabolic disorders, and reducing chronic inflammation. However, its effects on HS remain underexplored. In this prospective pilot study, we aimed to investigate the impact of a 28-day active phase VLCKD sample treatment-naive women excess weight. Methods Twelve overweight or obesity (BMI 27.03 50.14 kg/m 2 ), aged 21 54 years, meeting inclusion/exclusion criteria agreeing adhere VLCKD, were included. Baseline lifestyle habits assessed. Sartorius score was used evaluate clinical severity HS. Anthropometric parameters (waist circumference, weight, height, body mass index), composition via bioelectrical impedance analysis, levels trimethylamine N-oxide (TMAO), oxidized low-density lipoprotein (oxLDL), derivatives reactive oxygen metabolites (dROMs) assessed at baseline after 28 days VLCKD. Results led general improvements anthropometric composition. Notably, reduction observed intervention (Δ%: − 24.37 ± 16.64, p < 0.001). This coincided decreases TMAO (p 0.001), dROMs = oxLDL 0.001) levels. Changes exhibited positive correlations changes 0.002). Conclusion demonstrated notable markers, highlighting potential utility managing association derangements obesity.

Язык: Английский

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Ketogenic Diet: A Review of Composition Diversity, Mechanism of Action and Clinical Application

Journal of Nutrition and Metabolism, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

The ketogenic diet (KD) is a special high‐fat, very low‐carbohydrate with the amount of protein adjusted to one’s requirements. By lowering supply carbohydrates, this induces considerable change in metabolism (of and fat) increases production ketone bodies. purpose article review diversity composition, mechanism action, clinical application risk associated KD. In last decade, more results diet’s effects on obesity, diabetes neurological disorders, among other examples have appeared. beneficial KD diseases are related reconstruction myelin sheaths neurons, reduction neuron inflammation, decreased reactive oxygen species, support dopamine production, repair damaged mitochondria formation new ones. Minimizing intake carbohydrates reduced absorption simple sugars, thereby decreasing blood glucose levels fluctuations glycaemia diabetes. Studies obesity indicate an advantage over diets terms weight loss. This may be due upregulation biological activity appetite‐controlling hormones, or lipogenesis, intensified lipolysis increased metabolic costs gluconeogenesis. However, it important aware side These include disorders digestive system as well headaches, irritability, fatigue, occurrence vitamin mineral deficiencies worsened lipid profile. Further studies aimed determine long‐term required.

Язык: Английский

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The Impact of a Very-Low-Calorie Ketogenic Diet on Monocyte Subsets of Patients with Obesity: A Pilot Study

Nutrients, Год журнала: 2025, Номер 17(2), С. 312 - 312

Опубликована: Янв. 16, 2025

Background/Objectives: Obesity is closely linked to chronic low-grade inflammation and the development of cardio-metabolic comorbidities. Monocyte subsets, which are crucial in immune responses, have been reported be altered individuals with obesity, potentially exacerbating inflammation. Although very-low-calorie ketogenic diets (VLCKDs) recognized for their efficacy promoting weight loss improving metabolic health, impact on circulating monocyte subsets remains poorly understood. The objective our study investigate VLCKDs subset distribution people obesity. Methods: Thirty-six participants were divided into four groups—healthy controls, obesity no dietary intervention, following either a low-calorie diet (LCD) or VLCKD 28 days. Blood samples analyzed assess classical monocytes (CMs), intermediate (IMs), non-classical (NCMs) using flow cytometry. Results: Individuals exhibited significant increases IMs NCMs, alongside decrease CMs compared healthy controls. led notable shift distribution, increased reduced restoring levels closer those observed individuals. In contrast, LCD group showed changes subsets. Conclusions: may exert anti-inflammatory effects by modulating offering potential therapeutic benefits mitigating obesity-related These preliminary findings suggest that could an effective strategy function

Язык: Английский

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Uncovering the Effect of SARS-CoV-2 on Liver Metabolism via Genome-Scale Metabolic Modeling for Reprogramming and Therapeutic Strategies

ACS Omega, Год журнала: 2024, Номер 9(13), С. 15535 - 15546

Опубликована: Март 22, 2024

Genome-scale metabolic models (GEMs) are promising computational tools that contribute to elucidating host-virus interactions at the system level and developing therapeutic strategies against viral infection. In this study, effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on liver metabolism was investigated using integrated GEMs human hepatocytes SARS-CoV-2. They were generated for uninfected infected transcriptome data. Reporter metabolite analysis resulted in significant transcriptional changes around several metabolites involved xenobiotics, drugs, arachidonic acid, leukotriene metabolisms due SARS-CoV-2 Flux balance minimization adjustment approaches unraveled possible virus-induced hepatocellular reprogramming fatty glycerophospholipid, sphingolipid cholesterol, folate metabolisms, bile acid biosynthesis, carnitine shuttle among others. Reaction knockout provided critical reactions glycolysis, oxidative phosphorylation, purine metabolism, reactive oxygen species detoxification subsystems. Computational also showed administration dopamine, glucosamine, D-xylose, cysteine, (

Язык: Английский

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Exploring the effect of different diet types on ageing and age-related diseases

Nutrition, Год журнала: 2024, Номер 129, С. 112596 - 112596

Опубликована: Окт. 10, 2024

Язык: Английский

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COVID-19 and Gastrointestinal Tract: From Pathophysiology to Clinical Manifestations

Medicina, Год журнала: 2023, Номер 59(10), С. 1709 - 1709

Опубликована: Сен. 24, 2023

Background: Since its first report in Wuhan, China, December 2019, COVID-19 has become a pandemic, affecting millions of people worldwide. Although the virus primarily affects respiratory tract, gastrointestinal symptoms are also common. The aim this narrative review is to provide an overview pathophysiology and clinical manifestations COVID-19. Methods: We conducted systematic electronic search English literature up January 2023 using Medline, Scopus, Cochrane Library, focusing on papers that analyzed role SARS-CoV-2 tract. Results: Our highlights directly infects tract can cause such as diarrhea, nausea/vomiting, abdominal pain, anorexia, loss taste, increased liver enzymes. These result from mucosal barrier damage, inflammation, changes microbiota composition. exact mechanism how overcomes acid gastric environment leads intestinal damage still being studied. Conclusions: vaccination prevalence less severe symptoms, long-term interaction with remains concern. Understanding interplay between essential for future management virus.

Язык: Английский

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Metabolomic alterations in the plasma of patients with various clinical manifestations of COVID-19

Virology Journal, Год журнала: 2024, Номер 21(1)

Опубликована: Окт. 28, 2024

The metabolomic profiles of individuals with different clinical manifestations severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have not been clearly characterized. We performed metabolomics analysis 166 individuals, including 62 healthy controls, 16 asymptomatic SARS-CoV-2 infection, and 88 patients moderate (n = 42) 46) symptomatic 2019 disease (COVID-19; 17 short-term 34 long-term nucleic-acid test positivity). By examining differential expression, we identified candidate metabolites associated presentations. Functional machine learning analyses were to explore the metabolites' functions verify their candidacy as biomarkers. A total 417 detected. discovered 70 differentially expressed that may help differentiate infections from controls COVID-19 severity. Cyclamic acid N-Acetylneuraminic Acid distinguish infected patients. Shikimic Acid, Glycyrrhetinic 3-Hydroxybutyrate can supply significant insights for distinguishing positivity. Metabolomic profiling highlight novel biomarkers identification further our understanding molecular pathogenesis COVID-19.

Язык: Английский

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The potential of ketogenic dietary therapy in the COVID-19 pandemic

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 79 - 104

Опубликована: Ноя. 29, 2024

Язык: Английский

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