Anti-HSV-1 agents: an update
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 21, 2025
Herpes
simplex
virus
type
I
(HSV-1)
is
a
member
of
the
α-herpesvirus
subfamily
and
capable
causing
herpes
keratitis,
labialis,
encephalitis.
HSV-1
well
known
for
its
lytic
infections
at
primary
sites
establishing
latency
in
sensory
neuronal
ganglia,
with
occasional
recurrent
infections.
To
date,
there
are
no
approved
commercially
available
vaccines,
anti-HSV-1
drugs
such
as
specific
or
non-specific
nucleotide
(nucleoside)
analogs
helicase-primase
inhibitors
have
become
main
clinical
agents
treatment
despite
challenges
from
resistance.
Therefore,
development
new
compounds
therapies
key
to
addressing
issue
The
present
review
provides
an
update
on
progress
made
over
approximately
60
years
regarding
while
also
highlighting
future
perspectives
controlling
Язык: Английский
New Insights Regarding the Use of Relevant Synthetic Compounds in Dentistry
Molecules,
Год журнала:
2024,
Номер
29(16), С. 3802 - 3802
Опубликована: Авг. 10, 2024
Worldwide,
synthetic
compounds
are
used
for
both
in-office
and
at-home
dental
care.
They
a
valuable
resource
prophylactic
curative
treatments
various
problems,
such
as
tooth
decay,
periodontal
diseases,
many
more.
typically
preferred
due
to
their
broad
range
of
actions
ability
produce
targeted,
rapid,
long-lasting
effects.
Using
0.12%
chlorhexidine
mouthwash
is
capable
reducing
the
plaque
index
from
47.69%
2.37%
bleeding
32.93%
6.28%
after
just
2
weeks.
Mouthwash
with
0.1%
OCT
also
highly
effective,
it
significantly
lowered
median
salivary
bacterial
counts
in
152
patients
5
days
compared
control
group
(p
<
0.0001),
while
gingival
0.001).
When
povidone-iodine
was
an
irrigant
during
surgical
removal
mandibular
third
molars
105
patients,
resulted
notably
lower
pain
scores
(4.57
±
0.60
vs.
5.71
0.45).
Sodium
hypochlorite
excellent
root
canal
disinfection,
irrigating
1%
NaOCl
completely
eliminated
bacteria
canals
65%
patients.
A
0.05%
CPC
proved
effective
perioperative
patient
care,
decreasing
0.001)
suppressing
Streptococcus
levels
even
one
week
post-surgery.
Lastly,
6%
H2O2
paint-on
varnish
tray
formulations
successfully
bleached
teeth
40
maintaining
noticeably
whiter
appearance
up
6-month
follow-up,
significant
color
differences
baseline
0.005).
Synthetic
have
large
research
base,
which
provides
greater
awareness
mechanism
action
potential
adverse
For
better
understanding
how
they
work,
several
methods
assays
performed.
These
protocolary
techniques
through
compound’s
efficacy
toxicity
established.
Язык: Английский
Comparing In Vitro Virucidal Efficacy of Commercially Available Mouthwashes Against Native High-Risk Human Papillomavirus Types 16 and 18
Microorganisms,
Год журнала:
2025,
Номер
13(4), С. 734 - 734
Опубликована: Март 25, 2025
The
rising
incidence
of
oropharyngeal
cancer
caused
by
high-risk
Human
Papillomavirus
(HPV)
type
16
and
HPV18
in
the
U.S
other
developed
countries
is
an
important
public
health
issue.
This
has
been
attributed
to
changes
sexual
behavior,
including
practice
oral
sex,
which
may
expose
individuals
increased
risk
acquiring
HPV
infection.
infections
highlights
role
cavity
as
anatomical
site
acquisition
transmission
HPVs.
Generally,
use
mouthwash/oral
rinses
have
focused
on
targeting
bacteriome,
could
additionally
be
formulated
for
managing
virome.
Here,
we
examined
virucidal
properties
common
over-the-counter
antibacterial
mouthwash
products
against
native
HPV16
virion
vitro,
downstream
modification
virus
infectivity.
We
tested
containing
essential
oils/alcohol,
hydrogen
peroxide,
cetylpyridinium
chloride.
Our
results
demonstrated
greater
than
90%
efficacy
inactivation,
but
comparatively
with
less
HPV18.
Overall,
peroxide
best
both
types,
albeit
lower
Prophylactic
targeted
towards
HPVs
beneficial
reducing
incidental
load,
prevalence,
persistent
infections.
Язык: Английский
Topical Ocular Drug Delivery: The Impact of Permeation Enhancers
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 447 - 447
Опубликована: Март 31, 2025
Topical
ophthalmic
drug
delivery
targeting
the
posterior
segment
of
eye
has
become
a
key
area
interest
due
to
its
non-invasive
nature,
safety,
ease
application,
patient
compliance,
and
cost-effectiveness.
However,
achievement
effective
bioavailability
in
ocular
is
significant
challenge
unique
barriers,
including
precorneal
factors
anatomical
like
cornea,
conjunctiva,
sclera.
Successful
systems
require
increased
residence
time
improved
corneal
penetration
enhance
intraocular
bioavailability.
A
promising
strategy
overcome
these
barriers
incorporating
enhancers
(DPEs)
into
formulations.
These
compounds
facilitate
by
improving
permeability
across
otherwise
impermeable
or
poorly
permeable
membranes.
At
level,
they
act
through
three
primary
mechanisms:
breaking
tear
film
stability
interfering
with
mucous
layer;
disrupting
membrane
components
such
as
phospholipids
proteins;
loosening
epithelial
cellular
junctions.
DPEs
offer
potential
improve
therapeutic
outcomes,
particularly
for
drugs
eye.
This
review
focused
on
analyzing
current
literature
regarding
use
topical
delivery,
highlighting
their
mechanisms
action
revolutionize
treatments.
Язык: Английский
Cetylpyridinium chloride and chlorhexidine show antiviral activity against Influenza A virus and Respiratory Syncytial virus in vitro
PLoS ONE,
Год журнала:
2024,
Номер
19(2), С. e0297291 - e0297291
Опубликована: Фев. 16, 2024
Background
The
oral
cavity
is
the
site
of
entry
and
replication
for
many
respiratory
viruses.
Furthermore,
it
source
droplets
aerosols
that
facilitate
viral
transmission.
It
thought
appropriate
hygiene
alters
infectivity
might
reduce
spread
viruses
contribute
to
infection
control.
Materials
methods
Here,
we
analyzed
antiviral
activity
cetylpyridinium
chloride
(CPC),
chlorhexidine
(CHX),
three
commercial
CPC
CHX-containing
mouthwash
preparations
against
Influenza
A
virus
Respiratory
syncytial
virus.
To
do
so
aforementioned
compounds
were
incubated
with
or
Next,
viability
treated
particles.
Results
Our
results
indicate
CHX
decrease
both
Syncytial
in
vitro
between
90
99.9%
depending
on
concentration.
Likewise,
up
99.99%
effective
decreasing
.
Conclusion
use
a
containing
alone
combination
represent
cost-effective
measure
limit
enveloped
infecting
cavity,
aiding
reducing
findings
may
stimulate
future
clinical
studies
evaluate
effects
transmissions.
Язык: Английский
Influence of Five Different Commercially Available Mouthwashes on the Growth of Candida albicans Adhered to Customized Prefabricated Heat-Cured Denture Base Acrylic Resin Sheets: An In Vitro Study
Neethu Niduvote Poyil,
Pattathil Abdul Razak,
Aysha Mohamed Ali
и другие.
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 15, 2024
Background
The
purpose
of
this
in
vitro
investigation
was
to
evaluate
the
impact
five
distinct
commercial
mouthwashes
on
development
Candida
albicans
that
had
been
adhered
heat-cured
acrylic
resin
sheets.
Methods
This
carried
out
at
MES
Medical
College's
Microbiology
Department
Perinthalmanna,
Kerala,
India.
A
total
72
sheets,
size
10
×
2
mm,
were
fabricated.
After
disinfection,
all
sheets
placed
a
flask
containing
suspension
standard
strain
species
(American
Type
Culture
Collection)
and
incubated
37ºC
for
24
hours.
Then,
randomly
divided
into
six
groups,
with
each
group
12
Group
1
control
which
no
mouthwash
added.
In
2,
Colgate
Plax
3,
Hiora
Himalaya
4,
Oral
B
5,
Listerine
6,
Pepsodent
Colony-forming
units
(CFUs)
assessed
using
colony
counter
every
six,
24,
48,
120
obtaining
pH
CFU
specimens,
software
known
as
Statistical
Package
Social
Sciences
(SPSS)
(IBM
Corp.,
Armonk,
NY)
used
analyze
data.
Results
denture
base
differed
significantly
response
commercially
available
(Oral
B,
Plax,
Pepsodent)
non-commercial
(Hiora
Listerine)
contained
cetylpyridinium
chloride.
Conclusions
Compared
other
do
not
contain
chloride
(Listerine
Himalaya),
active
ingredient
Pepsodent,
Plax)
have
shown
good
antifungal
properties
against
adhering
resin.
Язык: Английский
An exploratory study of drug concentration and inhibitory effect of cetylpyridinium chloride buccal tablets on SARS‐CoV‐2 infection among 10 Chinese subjects
Fundamental and Clinical Pharmacology,
Год журнала:
2023,
Номер
38(3), С. 579 - 587
Опубликована: Ноя. 20, 2023
Abstract
Background
It
was
evidenced
that
cetylpyridinium‐chloride
(CPC)
mouthwash
could
inhibit
SARS‐COV‐2
activity
and
reduce
salivary
viral
load,
thus
reducing
SARS‐CoV‐2
transmission.
However,
due
to
insufficient
residence
time
in
the
oral
cavity,
CPC‐containing
mouthwashes
have
no
prolonged
antiviral
effect.
The
duration
of
action
CPC
buccal
tablet
is
expected
be
longer
than
mouthwash.
there
are
currently
reports
on
drug
concentration
tablets.
Objective
study
aimed
investigate
tablets
effect
vitro.
Trial
design
This
a
single‐dose,
single‐arm
clinical
trial,
involving
10
Chinese
healthy
subjects
who
received
2‐mg
collect
saliva
samples
detect
at
different
timepoints
within
2
h
(Clinical
Registration
Number:
NCT05802628,
Date:
April
6,
2023).
Materials
methods
detected
by
liquid
chromatography
tandem
mass
spectrometry
(LC–MS/MS),
pharmacokinetic
parameters
were
calculated
based
non‐compartmental
model.
With
an
vitro
experiment,
against
its
cellular
toxicity
tested.
Results
Drug
concentrations
15
min,
30
1
h,
1.5
after
administration
8008.33
(1042.25,
41081.11),
2093.34
(373.15,
5759.83),
1016.58
(378.66,
3480.68),
891.77
(375.66,
6322.07),
717.43
(197.87,
2152.71)
ng/mL.
PK
concentration:
C
max
=
41081.11)
ng/mL,
AUC
0‐t
4172.37
(904.42,
13912.61)
ng/mL
*
0‐∞
6712.85
(1856.77,
19971.12)
T
1/2
1.22
(0.59,
2.83)
0.25
(0.25,
0.25)
h.
As
determined
active
with
cytotoxic
inhibitory
CC50
35.75
μM
(≈12155
ng/mL)
EC50
7.39
(≈2512.6
ng/mL).
Conclusions
comparison
between
EC50/CC50
values
from
experiments
suggests
may
activity,
inhibition
last
for
approximately
min
without
cytotoxicity.
Язык: Английский