Toward a Categorization of Virus-ncRNA Interactions in the World of RNA to Disentangle the Tiny Secrets of Dengue Virus

Viruses, Год журнала: 2024, Номер 16(5), С. 804 - 804

Опубликована: Май 18, 2024

In recent years, the function of noncoding RNAs (ncRNAs) as regulatory molecules cell physiology has begun to be better understood. Advances in viral molecular biology have shown that host ncRNAs, cellular factors, and virus-derived ncRNAs their interplay are strongly disturbed during infections. Nevertheless, folding RNA virus genomes also been identified a critical factor regulating canonical non-canonical functions. Due influence structure genomes, complex processes infections modulated. We propose three main categories organize current information about RNA–RNA interactions some well-known human viruses. The first category shows examples associated with immune response triggered Even though miRNAs introduce standpoint, they briefly presented keep researchers moving forward uncovering other RNAs. second outlines between virus-host while third describes how genome serves scaffold for processing Our grouping may provide comprehensive framework classify ncRNA–host-cell emerging viruses diseases. this sense, we introduced them DENV–host-cell interactions.

Язык: Английский

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Decoding LncRNA in COPD: Unveiling Prognostic and Diagnostic Power and Their Driving Role in Lung Cancer Progressions

Опубликована: Июль 3, 2024

Keywords: Chronic Obstructive Pulmonary Disease (COPD), Long Non-Coding RNAs (lncRNAs), Molecular Pathogenesis, Inflammation, Lung Cancer, Diagnostic Biomarkers

Язык: Английский

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Decoding LncRNA in COPD: Unveiling Prognostic and Diagnostic Power and Their Driving Role in Lung Cancer Progression

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 9001 - 9001

Опубликована: Авг. 19, 2024

Chronic obstructive pulmonary disease (COPD) and lung cancer represent formidable challenges in global health, characterized by intricate pathophysiological mechanisms multifaceted progression. This comprehensive review integrates insights from diverse perspectives to elucidate the roles of long non-coding RNAs (lncRNAs) pathogenesis COPD cancer, focusing on their diagnostic, prognostic, therapeutic implications. In context COPD, dysregulated lncRNAs, such as NEAT1, TUG1, MALAT1, HOTAIR, GAS5, emerge pivotal regulators genes involved Their identification, profiling, correlation with severity present promising avenues for prognostic diagnostic applications, thereby shaping personalized interventions. These lncRNAs are also implicated underscoring potential across both diseases. domain play modulatory progression, offering innovative approaches indicators. LncRNA-mediated immune responses have been shown drive progression modulating tumor microenvironment, influencing cell infiltration, altering cytokine production. dysregulation significantly contributes growth, metastasis, chemo-resistance, emphasizing significance targets markers. summarizes transformative lncRNA-based diagnostics therapeutics valuable into future research directions clinical translation development.

Язык: Английский

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Human cytomegalovirus microRNAs: strategies for immune evasion and viral latency

Archives of Virology, Год журнала: 2024, Номер 169(8)

Опубликована: Июль 6, 2024

Язык: Английский

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