Epigenetic modulation by oncolytic viruses: Implications for cancer therapeutic efficacy
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2025,
Номер
unknown, С. 189270 - 189270
Опубликована: Янв. 1, 2025
Язык: Английский
Incorporating Intracellular Processes in Virus Dynamics Models
Microorganisms,
Год журнала:
2024,
Номер
12(5), С. 900 - 900
Опубликована: Апрель 30, 2024
In-host
models
have
been
essential
for
understanding
the
dynamics
of
virus
infection
inside
an
infected
individual.
When
used
together
with
biological
data,
they
provide
insight
into
viral
life
cycle,
intracellular
and
cellular
virus–host
interactions,
role,
efficacy,
mode
action
therapeutics.
In
this
review,
we
present
standard
model
highlight
situations
where
added
complexity
accounting
processes
is
needed.
We
several
examples
from
acute
chronic
infections
such
inclusion
in
explicit
implicit
manner
has
led
to
improvement
parameter
estimates,
unification
conclusions,
guidance
targeted
therapeutics,
crossover
among
systems.
also
discuss
trade-offs
between
realism
predictive
power
need
increased
data
collection
at
finer
scale
resolution
better
validate
complex
models.
Язык: Английский
Spatiotemporal spread of oncolytic virus in a heterogeneous cell population
Computers in Biology and Medicine,
Год журнала:
2024,
Номер
183, С. 109235 - 109235
Опубликована: Окт. 5, 2024
Язык: Английский
Bistability and chaotic behaviors in a 4D cancer oncolytic Virotherapy mathematical model: Pspice and FPGA implementations
Physica Scripta,
Год журнала:
2024,
Номер
99(3), С. 035227 - 035227
Опубликована: Фев. 2, 2024
Abstract
Oncolytic
viruses
(OVs)
exploit
characteristics
of
mass
cells
and
tumor-related
reaction
the
body
to
presence
antigen,
lyse
malignant
modulate
tumor
microenvironment.
However,
effective
clinical
utilization
these
powerful
treatment
modules
necessitates
their
logical
control,
especially
in
order
prevent
solid
metastatic
outgrowths.
Hence,
it
is
imperative
develop
methods
protect
a
virus
from
annihilating
surroundings
bloodstream
when
traveling
locations.
Our
article
reports
on
bistability
chaotic
behavior
4D
cancer
virotherapy
model.
We
find
that
unstable,
stable
behaviors
can
appear
model
tuning
some
its
parameters.
With
help
chart
dynamic
parameter
spaces,
numerical
investigations
system’s
are
analyzed
followed
by
discussion
obtained
results.
It
appears
local
transition
change
an
invariant
one-torus
(IT1)
two-torus
(IT2)
counterpart
be
found
system
this
undergoes
Neimark-Saker
(NS)
direction.
As
increasing
rate
immune
effector
enhance,
amount
increases
as
consequence,
dynamics
becomes
with
pronounced
Lyapunov
exponent.
This
result
failure
due
interference
viruses.
also
focus
our
study
deign
ad-hoc
electronic
Field
Programmable
Gate
Arrays
(FPGA)
implementations
virotherapy’s
model,
illustrate
Язык: Английский