Molecules,
Год журнала:
2025,
Номер
30(2), С. 207 - 207
Опубликована: Янв. 7, 2025
The
scientific
interest
in
the
chemical
modification
of
chitosan
to
increase
its
solubility
and
application
has
led
conjugation
with
Schiff
bases,
which
are
interesting
scaffolds
endowed
diverse
biological
properties.
resultant
chitosan-based
bases
(CSBs)
widely
studied
literature
due
myriad
activities
exerted,
both
catalytic
biological,
including
anticancer,
anti-inflammatory,
antioxidant,
especially
antimicrobial
ones.
Antimicrobial
resistance
(AMR)
is
one
major
public
health
challenges
twenty-first
century
because
it
represents
a
threat
prevention
treatment
growing
number
bacterial,
parasitic,
viral,
fungal
infections
that
no
longer
treatable
available
drugs.
Thus,
this
review,
we
present
brief
outline
CSBs
as
well
their
complexes
metals,
particular
focus
on
recent
regarding
effect
these
captivating
derivatives.
Antibiotics,
Год журнала:
2025,
Номер
14(1), С. 63 - 63
Опубликована: Янв. 9, 2025
Multidrug
antimicrobial
resistance
(AMR)
represents
a
formidable
challenge
in
the
therapy
of
infectious
diseases,
triggered
by
particularly
concerning
gram-negative
Enterococcus
faecium,
Staphylococcus
aureus,
Klebsiella
pneumoniae,
Acinetobacter
baumannii,
Pseudomonas
aeruginosa,
and
Enterobacter
spp.
(ESKAPE)
pathogens.
Designated
as
"priority"
2017,
these
bacteria
continue
to
pose
significant
threat
2024,
during
worldwide
SARS-CoV-2
pandemic,
where
coinfections
with
ESKAPE
members
contributed
worsened
patient
outcomes.
The
declining
effectiveness
current
treatments
against
pathogens
has
led
an
increased
disease
burden
increase
mortality
rates
globally.
This
review
explores
sophisticated
mechanisms
driving
AMR
bacteria,
focusing
on
Key
bacterial
contributing
include
limitations
drug
uptake,
production
antibiotic-degrading
enzymes,
alterations
target
sites,
enhanced
efflux
systems.
Comprehending
pathways
is
vital
for
formulating
innovative
therapeutic
strategies
tackling
ongoing
posed
resistant
Pediatric Reports,
Год журнала:
2024,
Номер
16(1), С. 135 - 150
Опубликована: Фев. 2, 2024
In
the
developed
world,
pediatric
obesity
(PO)
has
been
a
major
health
concern
since
last
century,
and
this
condition
may
lead
to
detrimental
life-long
physical
mental
comorbidities.
Currently,
its
prevalence
increased
in
low-
middle-income
countries
many
high-income
countries.
Thus,
provision
of
effective
tailored
care
for
children
their
families
become
vital.
The
social
consequences
COVID-19
pandemic
are
known
everywhere,
among
these,
it
argued
that
had
impact
on
PO.
Overall,
growth
PO
over
decade
enhanced
by
pandemic.
During
pandemic,
children,
adolescents
young
adults
gained
weight
as
population
dealt
with
sedentary
lifestyles
changes
food
habits.
review,
we
want
highlight
Abstract
The
genus
Enterobacter
belongs
to
the
ESKAPE
group,
which
includes
Enterococcus
faecium
,
Staphylococcus
aureus
Klebsiella
pneumoniae
Acinetobacter
baumannii
Pseudomonas
aeruginosa
and
spp
.
This
group
is
characterized
by
development
of
resistance
various
antibiotics.
In
recent
years,
cloacae
(
E.
)
has
emerged
as
a
clinically
important
pathogen
responsible
for
wide
range
healthcare-associated
illnesses.
Identifying
species
can
be
challenging
due
their
similar
phenotypic
characteristics.
emergence
multidrug-resistant
also
significant
problem
in
healthcare
settings.
Therefore,
our
study
aimed
identify
differentiate
using
Matrix-assisted
laser
desorption
ionization–time
flight
mass
spectrometry
(MALDI-TOF
MS)
fast
precise
proteomic
analytical
technique.
We
tested
hospital-acquired
isolates
that
produce
Extended-spectrum
beta-lactamases
(ESBL)
against
commonly
used
antibiotics
treating
urinary
tract
infections
(UTIs).
total
189
from
2300
urine
samples
patients
with
UTIs
investigation.
employed
culturing
techniques,
well
BD
Phoenix™
automated
identification
system
(Becton,
Dickinson)
Analytical
Profile
Index
(API)
biochemical
isolates.
MALDI
Biotyper
(MBT)
device
peptide
fingerprinting
analysis
all
utilized
single
peak
intensities
Principal
Component
Analysis
(PCA)
created
MBT
Compass
software
discriminate
cluster
Additionally,
we
evaluated
sensitivity
ESBL-
Kirby
Bauer
method.
Out
isolates,
Phoenix
correctly
identified
180
(95.24%)
while
API
165
(87.30%)
However,
accurately
185
(98.95%)
score
2.00
or
higher.
PCA
positively
discriminated
into
one
prominent
peaks
were
noticed
between
4230
mass-to-charge
ratio
(m/z)
8500
m/z.
exhibited
higher
degree
ampicillin,
amoxicillin-clavulanate,
cephalothin,
cefuroxime,
cefoxitin.
Several
susceptible
carbapenems
(meropenem,
imipenem,
ertapenem);
however,
potential
future
should
taken
consideration.
conclusion,
MALDI-TOF
MS
powerful
technology
routinely
recognize
pathogens
clinical
samples.
growing
antimicrobial
this
bacterium
may
pose
risk
human
health.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(4), С. 407 - 407
Опубликована: Март 22, 2024
We
aimed
to
determine
the
trend
of
antimicrobial
resistance
pattern
pathogens
isolated
in
samples
collected
from
patients
hospitalized
intensive
care
unit
(ICU)
selected
periods
before
and
after
COVID-19.
A
retrospective
study
bacterial
was
performed
on
1267
patients.
Positive
culture
data
1695
pre-COVID-19
period
1562
post-COVID-19
were
obtained.
The
most
frequently
bacteria
both
Staphylococcus
aureus
Klebsiella
spp.
rates
Significantly
increased
against
colistin
(0.38%
20.51%),
gentamicin
(44.62%
64.85%),
aztreonam
(56.35%
3.60%).
There
a
significant
increase
rate
for
E.
coli
strains
(4.69%
32.46%)
Acinetobacter
sp.
(3.37%
18.09%).
More
than
50%
MRSA,
with
statistically
increases
doxycycline
(40.08%
51.72%),
linezolid
(0.22%
3.13%),
rifampicin
(53.16%
64.93%),
teicoplanin
(26.31%
53.40%).
revealed
significantly
increasing
Gram-negative
certain
antibiotics,
including
those
used
only
cases
where
there
are
no
other
therapeutic
options.
Organics,
Год журнала:
2024,
Номер
5(4), С. 395 - 428
Опубликована: Окт. 21, 2024
From
Egyptian
mummies
to
the
Chanel
N°
5
perfume,
aldehydes
have
been
used
for
a
long
time
and
continue
impact
our
senses
in
wide
range
of
perfumes,
foods,
beverages.
Aldehydes
represent
one
categories
volatile
organic
compounds
(VOCs),
which
are
categorized
as
chemicals
with
boiling
points
up
260
°C
can
be
found
indoor
environments
gaseous
phase.
Because
their
potential
or
known
hazardous
properties
humans,
World
Health
Organization
(WHO)-Europe
provided
some
guidelines
that
may
prevent
several
health
risks.
Indeed,
aldehydes,
reported
risky
retired
from
market,
such
butylphenyl
methylpropional
(BMHCA).
The
purpose
this
review
is
summarize
most
important
indoors
outdoors
analyse
depth
toxicological
aspects
these
compounds,
whose
presence
perfumes
often
underestimated.
In
addition,
ingredients’
synonyms
literature
same
compound
were
unified
order
simplify
identification.
Applied Microbiology,
Год журнала:
2025,
Номер
5(1), С. 9 - 9
Опубликована: Янв. 18, 2025
Background:
Acinetobacter
baumannii
is
a
major
cause
of
nosocomial
infections
in
critically
ill
patients,
and
strains
are
frequently
multidrug
resistant
(MDR).
This
study
aimed
to
characterize
45
clinical
A.
isolates
collected
different
periods
the
main
hospital
Molise
Region,
central
Italy.
Methods:
Antimicrobial
susceptibility
was
evaluated
using
an
automated
system,
PCRs
were
performed
detect
resistance-associated
genes.
Pulsed-field
gel
electrophoresis
(PFGE)
carried
out
with
AscI
ApaI,
Multi-locus
sequence
typing
(MLST)
according
Oxford
scheme.
Results:
All
exhibited
MDR
profiles,
showing
total
towards
colistin.
harbored
blaOXA-23,
blaOXA-51,
blaAmpC
genes,
as
well
adeB,
adeJ,
adeG,
abeS,
soxR.
Dendrogram
ApaI
revealed
eleven
three
clusters,
respectively,
twenty-three
eighteen
pulsotypes
(Simpson’s
index
0.96
0.93),
from
clearly
distinguished.
MLST
five
types,
which
varied
depending
on
isolation
period,
ST1720
ST369
prevalent,
followed
by
ST281,
ST218,
ST513.
Conclusions:
Molecular
characterization
enables
identification
distinct
patterns
over
time,
underscoring
its
usefulness
for
improving
epidemiological
surveillance
combating
antimicrobial
resistance.
provides
previously
unavailable
information
regarding
circulating
examined
setting.
Antibiotics,
Год журнала:
2025,
Номер
14(2), С. 186 - 186
Опубликована: Фев. 12, 2025
Antimicrobial
resistance
(AMR)
is
an
escalating
global
health
threat,
projected
to
cause
over
40
million
deaths
by
2050.
ESKAPE
pathogens
(Enterococcus
faecium,
Staphylococcus
aureus,
Klebsiella
pneumoniae,
Acinetobacter
baumannii,
Pseudomonas
aeruginosa,
and
Enterobacter
spp.)
are
major
contributors
nosocomial
infections
AMR.
We
evaluated
the
epidemiology
AMR
prevalence
of
at
University
Hospital
in
Palermo
between
January
2018
July
2023,
analyzing
factors
associated
with
mortality
patients
positive
blood
cultures.
Microbiological
data
from
all
specimen
types
were
collected
using
Business
Intelligence
system
Biwer,
excluding
duplicates.
assessed
trends
isolates
time.
Clinical
hospital
discharge
forms
used
evaluate
ESKAPE-positive
Differences
non-blood
examined.
A
total
11,607
specimens
4916
analyzed.
Most
admitted
Internal
Medicine
(19.4%),
ICU
(13.2%),
General
Surgery
(9.9%).
Additionally,
21.5%
ICU-admitted
patients.
Blood
cultures
accounted
for
14.3%
specimens,
urine
25.3%,
respiratory
secretions
22.1%,
skin
mucosal
swabs
20.9%.
The
increased
progressively,
peaking
2021.
vancomycin-resistant
E.
faecium
was
19.4%,
a
significant
upward
trend,
while
oxacillin-resistant
S.
aureus
35.0%,
showing
decline.
A.
baumannii
exhibited
high
antibiotics
tested
except
colistin
cefiderocol.
Carbapenemase
55.0%
K.
20.4%
P.
4.6%
spp.
aeruginosa
showed
decrease
meropenem
resistance.
pneumoniae
bloodstream
linked
higher
risk.
